Reference-Free Evaluation of Reasoning in Open-Ended Question Answering
On the map: LLM reasoning → Clinical and biomedical applications
Abstract (arXiv)
AI-generated answers in high-stakes domains are often fluent but difficult to verify, especially when they contain multi-step reasoning rather than a single final answer. We propose a reasoning-based, reference-free framework for auditing LLM-generated outputs. The method decomposes a generated reasoning trace into segments, labels local premise-target relations using Natural Language Inference (NLI), and organizes these relations into a hypergraph. A deterministic backward AND-OR search then assigns segment-level audit labels that indicate how each segment is grounded within the generated response. We evaluate the framework in two settings: deductive mathematical reasoning with Hard2Verify, and open-ended medical reasoning with UroReason, a new physician-annotated benchmark of LLM reasoning traces from real clinical cases. Across these settings, our NLI-hypergraph audit provides a more reliable reference-free evaluation signal than direct LLM-as-judge baselines. In the clinical setting, state-of-the-art LLM judges often fail to identify problematic reasoning segments, over-accepting fluent but weakly grounded responses. Our results show that QA evaluation should account for how inferential relations compose across a reasoning trace, rather than relying only on final answers or LLMs as verifiers. UroReason will be made available through an API, and our code will be released as open source.
Key facts. No citing papers in the map yet (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 18 of its 19 references that are in the map. First posted on arXiv 22 Jul 2026.
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References · 18
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6 more
- 2025Neither Valid nor Reliable? Investigating the Use of LLMs as Judgescited by 39
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- 2025Automating Expert-Level Medical Reasoning Evaluation of Large Language Models
- 2025MedOmni-45deg: A Safety-Performance Benchmark for Reasoning-Oriented LLMs in Medicine
- 2026CLExEval: A Human-in-the-Loop Framework for Qualitative Evaluation of LLM Clinical Reasoning
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- 2025Quantifying the Reasoning Abilities of LLMs on Real-world Clinical Cases
- 2026Advances in LLM Reasoning Enable Flexibility in Clinical Problem-Solving
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- 2026Closing Reasoning Gaps in Clinical Agents with Differential Reasoning Learning