mlsanityData to 14 Oct 2026

Interpretable Language Model for Closed-Loop Type 1 Diabetes Control

arXiv 2607.14126 ↗First posted 19 Jun 2026cs.AI cs.CL cs.LGcited by 0

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Abstract (arXiv)

Type 1 Diabetes (T1D) is a chronic, life-threatening autoimmune condition characterized by the complete destruction of insulin-producing pancreatic beta cells. While Artificial Pancreas Systems (APS) powered by Reinforcement Learning (RL) have shown promise in automating insulin delivery, their ``black-box'' nature makes it hard for patients and doctors to trust them fully. This paper presents LLM-T1D, a promising approach that combines the precision of RL with the clear, human-like reasoning of Large Language Models (LLMs) to create a more transparent and reliable insulin pump controller. By training an expert RL system and distilling its knowledge into fine-tuned LLaMA 3.1 8B and Qwen3 8B models, we developed a controller that not only surpasses the RL system's performance but also explains its decisions in plain, understandable language. Tested on the FDA-approved UVA/Padova T1D simulator, the LLM controllers deliver excellent blood sugar control (73.5% Time in Range) while maintaining strict formal safety verification against hallucinations.

Key facts. No citing papers in the map yet (data through 14 Oct 2026). Builds on 3 of its 19 references that are in the map. First posted on arXiv 19 Jun 2026.

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3 of 19 references.

References · 3

  1. 2021LoRA: Low-Rank Adaptation of Large Language Modelscited by 14,380
  2. 2025Beyond Distillation: Pushing the Limits of Medical LLM Reasoning with Minimalist Rule-Based RLcited by 36
  3. 2020Deep Reinforcement Learning for Closed-Loop Blood Glucose Controlcited by 26

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  1. 2026GUIDE: Reinforcement Learning for Behavioral Action Support in Type 1 Diabetes
  2. 2025Are Large Language Models Dynamic Treatment Planners? An In Silico Study from a Prior Knowledge Injection Angle
  3. 2022Offline Reinforcement Learning for Safer Blood Glucose Control in People with Type 1 Diabetes
  4. 2025Flexible Blood Glucose Control: Offline Reinforcement Learning from Human Feedback
  5. 2025Precise Insulin Delivery for Artificial Pancreas: A Reinforcement Learning Optimized Adaptive Fuzzy Control Approach
  6. 2024Attention Networks for Personalized Mealtime Insulin Dosing in People with Type 1 Diabetes
  7. 2024DIETS: Diabetic Insulin Management System in Everyday Life ↗
  8. 2024Blood Glucose Control Via Pre-trained Counterfactual Invertible Neural Networks