IsoSci: A Benchmark of Isomorphic Cross-Domain Science Problems for Evaluating Reasoning versus Knowledge Retrieval in LLMs
On the map: LLM reasoning → Knowledge- and tool-augmented reasoning
Abstract (arXiv)
We introduce ISOSCI, a benchmark of isomorphic cross-domain science problem pairs that separates reasoning ability from domain knowledge retrieval in LLM evaluation. Each pair shares identical logical structure but requires different domain-specific knowledge, enabling controlled attribution of reasoning-mode gains. Across five model pairs spanning four model families, we find that 91.3% of reasoning-mode gains are knowledge-dependent rather than structure-invariant (63/69 gains; Wilson 95% CI [82.3%, 96.0%]), directly challenging the assumption that chain-of-thought reasoning improves short-horizon procedural scientific problem-solving. Reasoning toggles on highly capable models provide less than 5 percentage points accuracy gain across all domains, and a reasoning-specialized model (o3-mini) that outperforms its standard counterpart on GPQA Diamond (+19.2 percentage points) underperforms on ISOSCI (-24.7 percentage points), showing that benchmark choice determines conclusions about reasoning utility. We release ISOSCI at https://huggingface.co/datasets/isosci/isosci
Key facts. No citing papers in the map yet (data through 7 Oct 2026). Placed in Knowledge- and tool-augmented reasoning, one of 17 directions in LLM reasoning. Builds on 23 of its 30 references that are in the map. First posted on arXiv 1 Jul 2026.
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23 of 30 references.
References · 23
- 2022Chain-of-Thought Prompting Elicits Reasoning in Large Language Modelscited by 12,302
- 2020Measuring Massive Multitask Language Understandingcited by 7,768
- 2025DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learningcited by 6,146
- 2022Self-Consistency Improves Chain of Thought Reasoning in Language Modelscited by 5,601
- 2023GPQA: A Graduate-Level Google-Proof Q&A Benchmarkcited by 2,748
- 2022Solving Quantitative Reasoning Problems with Language Modelscited by 1,359
- 2023Faith and Fate: Limits of Transformers on Compositionalitycited by 496
- 2023SciBench: Evaluating College-Level Scientific Problem-Solving Abilities of Large Language Modelscited by 246
- 2024FrontierMath: A Benchmark for Evaluating Advanced Mathematical Reasoning in AIcited by 227
- 2023Guiding Language Model Reasoning with Planning Tokenscited by 58
- 2024Disentangling Memory and Reasoning Ability in Large Language Modelscited by 43
- 2025Rethinking Fine-Tuning when Scaling Test-Time Compute: Limiting Confidence Improves Mathematical Reasoningcited by 28
11 more
- 2025A Tutorial on LLM Reasoning: Relevant Methods behind ChatGPT o1cited by 24
- 2025The Reasoning-Memorization Interplay in Language Models Is Mediated by a Single Directioncited by 21
- 2025From Passive to Active Reasoning: Can Large Language Models Ask the Right Questions under Incomplete Information?cited by 21
- 2024SocialGPT: Prompting LLMs for Social Relation Reasoning via Greedy Segment Optimizationcited by 14
- 2025PhysUniBench: A Multi-Modal Physics Reasoning Benchmark at Undergraduate Levelcited by 14
- 2025Have Large Language Models Learned to Reason? A Characterization via 3-SAT Phase Transitioncited by 13
- 2025GPO: Learning from Critical Steps to Improve LLM Reasoningcited by 10
- 2025Theorem-of-Thought: A Multi-Agent Framework for Abductive, Deductive, and Inductive Reasoning in Language Modelscited by 6
- 2025QuantumBench: A Benchmark for Quantum Problem Solvingcited by 3
- 2026Reasoning Gets Harder for LLMs Inside A Dialoguecited by 2
- 2026Beyond Output Correctness: Benchmarking and Evaluating Large Language Model Reasoning in Coding Taskscited by 1
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- 2025Demystifying Scientific Problem-Solving in LLMs by Probing Knowledge and Reasoning
- 2026SciR: A Controllable Benchmark for Scientific Reasoning in LLMs
- 2025SciVerse: Unveiling the Knowledge Comprehension and Visual Reasoning of LMMs on Multi-modal Scientific Problems
- 2026WildSci: Advancing Scientific Reasoning from In-the-Wild Literature
- 2026SciVQR: A Multidisciplinary Multimodal Benchmark for Advanced Scientific Reasoning Evaluation
- 2026ProjectionBench: Evaluating Scientific Hypothesis Generation in LLMs Under Progressive Information Disclosure
- 2025RAISE: Enhancing Scientific Reasoning in LLMs via Step-by-Step Retrieval
- 2026PaperMind: Benchmarking Agentic Reasoning and Critique over Scientific Papers in Multimodal LLMs