Memisis: Orchestrating and Evaluating Synthetic Data for Tabular Health Datasets
On the map: Synthetic data and self-improvement for LLMs → Medical synthetic data and agents
Abstract (arXiv)
Synthetic data is widely used in healthcare to create datasets that preserve statistical properties of real data without exposing sensitive patient information. Generating and evaluating synthetic data across privacy, utility, and fairness dimensions is crucial for enabling high-quality data availability in downstream prediction tasks and clinical decision making. We present Memisis, a tool that orchestrates and evaluates synthetic data by leveraging existing synthesis libraries, large language models (LLMs), and state-of-the-art evaluation metrics. Our tool creates a unified workflow for data generation, validation, and evaluation. Users can control training size, training epochs, and the number of synthetic rows to sample. Beyond manual configuration, an interactive agent mode allows users to specify data generation goals in natural language, and the tool orchestrates the full pipeline by invoking existing synthesizers while performing the requisite evaluation. For the demo, we use an open-source schizophrenia dataset with protected attributes related to race and gender, evaluate six synthesizers spanning GANs, VAEs, diffusion models, and normalizing flows, and use a local LLM to orchestrate the workflow. The system affords users flexibility and control over the data generation and evaluation process.
Key facts. No citing papers in the map yet (data through 7 Oct 2026). Placed in Medical synthetic data and agents, one of 13 directions in Synthetic data and self-improvement for LLMs. Builds on 4 of its 22 references that are in the map. First posted on arXiv 18 May 2026.
Builds on
4 of 22 references.
References · 4
- 2019A Survey on Bias and Fairness in Machine Learningcited by 1,911
- 2023Synthcity: facilitating innovative use cases of synthetic data in different data modalitiescited by 76
- 2025FairCauseSyn: Towards Causally Fair LLM-Augmented Synthetic Data Generationcited by 3
- 2025FairTabGen: High-Fidelity and Fair Synthetic Health Data Generation from Limited Samplescited by 1
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- 2025SynLLM: A Comparative Analysis of Large Language Models for Medical Tabular Synthetic Data Generation via Prompt Engineering
- 2025Generating Reliable Synthetic Clinical Trial Data: The Role of Hyperparameter Optimization and Domain Constraints
- 2024MALLM-GAN: Multi-Agent Large Language Model as Generative Adversarial Network for Synthesizing Tabular Data
- 2024A Multi-Faceted Evaluation Framework for Assessing Synthetic Data Generated by Large Language Models
- 2025A Scoping Review of Synthetic Data Generation by Language Models in Biomedical Research and Application: Data Utility and Quality Perspectives
- 2026Fidelity, Diversity, and Privacy: A Multi-Dimensional LLM Evaluation for Clinical Data Augmentation
- 2025A Reinforcement Learning Approach to Synthetic Data Generation
- 2025Risk In Context: Benchmarking Privacy Leakage of Foundation Models in Synthetic Tabular Data Generation