When Evidence Conflicts: Uncertainty and Order Effects in Retrieval-Augmented Biomedical Question Answering
On the map: Retrieval-augmented generation → Medical and biomedical RAG
Abstract (arXiv)
Biomedical retrieval-augmented large language models (LLMs) often face evidence that is incomplete, misleading, or internally contradictory, yet evaluation usually emphasizes answer accuracy under helpful context rather than reliability under conflict. Using HealthContradict, we evaluate six open-weight LLMs under five controlled evidence conditions: no retrieved context, correct-only context, incorrect-only context, and two mixed conditions containing both correct and contradictory documents in opposite orders. In this conflicting-evidence order contrast, where the same two documents are both present and only their order is reversed, accuracy drops for every model and 11.4%--25.2% of predictions flip. To support abstention in these difficult cases, we also evaluate a conflict-aware abstention score that combines model confidence with a detector of evidence conflict. In the two hardest conditions, this score improves selective accuracy over confidence-only, with mean gains of 7.2--33.4 points in incorrect-only (`IC') and 3.6--14.4 points in incorrect-first conflicting (`ICC') conditions across 75%, 50%, and 25% coverage. These results show that conflicting biomedical evidence is both an uncertainty and robustness problem and motivate evaluation and abstention methods that explicitly account for evidence disagreement.
Key facts. Cited by 1 paper in the map (data through 14 Oct 2026). Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation. Builds on 10 of its 15 references that are in the map. First posted on arXiv 13 May 2026.
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- 2020Retrieval-Augmented Generation for Knowledge-Intensive NLP Taskscited by 9,297
- 2017On Calibration of Modern Neural Networkscited by 4,960
- 2023Lost in the Middle: How Language Models Use Long Contextscited by 3,455
- 2022Language Models (Mostly) Know What They Knowcited by 1,856
- 2022Large Language Models Encode Clinical Knowledgecited by 1,830
- 2017Selective Classification for Deep Neural Networkscited by 852
- 2021Entity-Based Knowledge Conflicts in Question Answeringcited by 356
- 2020Selective Question Answering under Domain Shiftcited by 238
- 2025Mapping from Meaning: Addressing the Miscalibration of Prompt-Sensitive Language Modelscited by 11
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- 2026BELIEF: Structured Evidence Modeling and Uncertainty-Aware Fusion for Biomedical Question Answering
- 2026CLEAR: Revealing How Noise and Ambiguity Degrade Reliability in LLMs for Medicine
- 2025Evaluating Large Language Models for Evidence-Based Clinical Question Answering
- 2025HealthContradict: Evaluating Biomedical Knowledge Conflicts in Language Models
- 2025Introducing Answered with Evidence -- a framework for evaluating whether LLM responses to biomedical questions are founded in evidence
- 2026ERA: Evidence-based Reliability Alignment for Honest Retrieval-Augmented Generation
- 2026When Retrieval Doesn't Help: A Large-Scale Study of Biomedical RAG
- 2026CLEAR: Cross-Source Evidence Adjudication for Large Language Models in Medicine