Observable Neural ODEs for Identifiable Causal Forecasting in Continuous Time
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Abstract (arXiv)
Causal inference in continuous-time sequential decision problems is challenged by hidden confounding and partially observed states. We show that, under explicit structural assumptions, observability of the latent state enables identification of dynamic treatment effects through a continuous-time conditional front-door adjustment, even in the presence of hidden confounding. We derive a general adjustment formula and show that it reduces to a tractable state-space formula when unobserved contemporaneous disturbances are temporally uncorrelated. This formula expresses potential-outcome distributions under alternative treatment trajectories through the measurement model, latent dynamics, and the filtering distribution over latent states. We propose Observable Neural ODEs (ObsNODEs), Neural ODE models in observable normal form that implement this tractable adjustment for causal forecasting. ObsNODEs learn continuous-time dynamics with states reconstructible from observations, enabling outcome prediction under alternative treatment paths. Experiments on synthetic, semi-synthetic, and real-world clinical data demonstrate strong performance over recent sequence models, including external validation.
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References · 14
- 2018Neural Ordinary Differential Equationscited by 3,733
- 2020Neural Controlled Differential Equations for Irregular Time Seriescited by 501
- 2019Latent ODEs for Irregularly-Sampled Time Seriescited by 182
- 2020Estimating Counterfactual Treatment Outcomes over Time Through Adversarially Balanced Representationscited by 154
- 2022Causal Transformer for Estimating Counterfactual Outcomescited by 121
- 2016Variational Fourier features for Gaussian processescited by 85
- 2022Continuous-Time Modeling of Counterfactual Outcomes Using Neural Controlled Differential Equationscited by 59
- 2018Causal Modeling of Dynamical Systemscited by 24
- 2022Predicting the impact of treatments over time with uncertainty aware neural differential equationscited by 23
- 2023Causal Inference with Conditional Front-Door Adjustment and Identifiable Variational Autoencodercited by 17
- 2020G-Net: A Deep Learning Approach to G-computation for Counterfactual Outcome Prediction Under Dynamic Treatment Regimescited by 13
- 2024IGC-Net for conditional average potential outcome estimation over timecited by 10
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- 2026Causal State-Space Model for Causal Inference: Estimating Longitudinal Individual Treatment Effects
- 2026Orca: Neural Operators for Causal Reasoning in Continuous Time
- 2024A Dynamical View of the Question of Why
- 2026From Static Risk to Dynamic Trajectories: Toward World-Model-Inspired Clinical Prediction
- 2023Causal Modeling with Stationary Diffusions