Beyond Idealized Patients: Evaluating LLMs under Challenging Patient Behaviors in Medical Consultations
Not on the map. Why?
Abstract (arXiv)
Large language models (LLMs) are increasingly used for medical consultation and health information support, where safety depends not only on medical knowledge but also on robust responses to unclear, inconsistent, or misleading patient input. However, most existing medical LLM evaluations assume idealized and well-posed patient questions, limiting their realism. We study challenging patient behaviors that commonly arise in real medical consultations and complicate safe clinical reasoning. We define four clinically grounded categories of such behaviors: information contradiction, factual inaccuracy, self-diagnosis, and care resistance. For each behavior, we specify concrete failure criteria that capture unsafe responses. Building on four existing medical dialogue datasets, we introduce CPB-Bench (Challenging Patient Behaviors Benchmark), a bilingual (English and Chinese) benchmark of multi-turn dialogues annotated for these behaviors. We find that although models perform well overall, they exhibit consistent behavior-specific failures, especially when handling contradictory or medically implausible patient information. We further evaluate four intervention strategies and find inconsistent improvements, with some interventions introducing unnecessary corrections.
Key facts. Cited by 3 papers in the map (data through 14 Oct 2026). Builds on 22 of its 91 references that are in the map. First posted on arXiv 31 Mar 2026.
Builds on
22 of 91 references.
References · 22
- 2022Large Language Models are Zero-Shot Reasonerscited by 4,374
- 2023Let's Verify Step by Stepcited by 3,789
- 2023Self-RAG: Learning to Retrieve, Generate, and Critique through Self-Reflectioncited by 1,839
- 2023Jailbroken: How Does LLM Safety Training Fail?cited by 1,651
- 2022Ignore Previous Prompt: Attack Techniques For Language Modelscited by 832
- 2023MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoningcited by 316
- 2024BioMistral: A Collection of Open-Source Pretrained Large Language Models for Medical Domainscited by 301
- 2024HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMscited by 265
- 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environmentscited by 231
- 2024Modeling Future Conversation Turns to Teach LLMs to Ask Clarifying Questionscited by 76
- 2020MedDG: An Entity-Centric Medical Consultation Dataset for Entity-Aware Medical Dialogue Generationcited by 45
- 2022A Benchmark for Automatic Medical Consultation System: Frameworks, Tasks and Datasetscited by 45
10 more
- 2025ALFA: Aligning LLMs to Ask Good Questions A Case Study in Clinical Reasoningcited by 25
- 2024MediTOD: An English Dialogue Dataset for Medical History Taking with Comprehensive Annotationscited by 22
- 2026AdaRubric: Task-Adaptive Rubrics for Reliable LLM Agent Evaluation and Reward Learningcited by 13
- 2025LLMs Struggle to Reject False Presuppositions when Misinformation Stakes are Highcited by 12
- 2024Chaos with Keywords: Exposing Large Language Models Sycophantic Hallucination to Misleading Keywords and Evaluating Defense Strategiescited by 10
- 2024Adversarial Attacks on Large Language Models in Medicinecited by 10
- 2025Towards Safe AI Clinicians: A Comprehensive Study on Large Language Model Jailbreaking in Healthcarecited by 10
- 2025The Alignment Waltz: Jointly Training Agents to Collaborate for Safetycited by 10
- 2025Empowering Healthcare Practitioners with Language Models: Structuring Speech Transcripts in Two Real-World Clinical Applicationscited by 7
- 2025ReSURE: Regularizing Supervision Unreliability for Multi-turn Dialogue Fine-tuningcited by 3
Built on by
Citing papers per year: 2026: 3.
3 papers.
- 2026MedDialBench: Benchmarking LLM Diagnostic Robustness under Parametric Adversarial Patient Behaviorscited by 4
- 2026MedBench v5: A Dynamic, Process-Oriented, and Hallucination-Aware Benchmark for Clinical Multimodal Modelscited by 0
- 2026MedDDC-Eval: Diagnosis-Decoupled Evaluation of Multi-Turn Medical Consultation Agentscited by 0
- 2026MedDDC-Eval: Diagnosis-Decoupled Evaluation of Multi-Turn Medical Consultation Agents21 Jul 2026
- 2026MedBench v5: A Dynamic, Process-Oriented, and Hallucination-Aware Benchmark for Clinical Multimodal Models23 Jun 2026
- 2026MedDialBench: Benchmarking LLM Diagnostic Robustness under Parametric Adversarial Patient Behaviors8 Apr 2026