RAG-X: Systematic Diagnosis of Retrieval-Augmented Generation for Medical Question Answering
On the map: Retrieval-augmented generation → Medical and biomedical RAG
Abstract (arXiv)
Automated question-answering (QA) systems increasingly rely on retrieval-augmented generation (RAG) to ground large language models (LLMs) in authoritative medical knowledge, ensuring clinical accuracy and patient safety in Artificial Intelligence (AI) applications for healthcare. Despite progress in RAG evaluation, current benchmarks focus only on simple multiple-choice QA tasks and employ metrics that poorly capture the semantic precision required for complex QA tasks. These approaches fail to diagnose whether an error stems from faulty retrieval or flawed generation, limiting developers from performing targeted improvement. To address this gap, we propose RAG-X, a diagnostic framework that evaluates the retriever and generator independently across a triad of QA tasks: information extraction, short-answer generation, and multiple-choice question (MCQ) answering. RAG-X introduces Context Utilization Efficiency (CUE) metrics to disaggregate system success into interpretable quadrants, isolating verified grounding from deceptive accuracy. Our experiments reveal an ``Accuracy Fallacy", where a 14% gap separates perceived system success from evidence-based grounding. By surfacing hidden failure modes, RAG-X offers the diagnostic transparency needed for safe and verifiable clinical RAG systems.
Key facts. Cited by 2 papers in the map (data through 14 Oct 2026). Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation. Builds on 18 of its 33 references that are in the map. First posted on arXiv 3 Mar 2026.
Builds on
18 of 33 references.
Closest ancestors · 2
Same direction, newest first
- 2024Comprehensive and Practical Evaluation of Retrieval-Augmented Generation Systems for Medical Question Answering14 Nov
- 2024Benchmarking Retrieval-Augmented Generation for Medicine20 Feb
Other references · 16
- 2024The Llama 3 Herd of Modelscited by 14,715
- 2020Retrieval-Augmented Generation for Knowledge-Intensive NLP Taskscited by 9,297
- 2023Judging LLM-as-a-Judge with MT-Bench and Chatbot Arenacited by 8,626
- 2024Qwen2 Technical Reportcited by 2,120
- 2022Survey of Hallucination in Natural Language Generationcited by 2,075
- 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,288
- 2025Qwen3 Embedding: Advancing Text Embedding and Reranking Through Foundation Modelscited by 1,261
- 2023Ragas: Automated Evaluation of Retrieval Augmented Generationcited by 418
- 2023ARES: An Automated Evaluation Framework for Retrieval-Augmented Generation Systemscited by 265
- 2023MedCPT: Contrastive Pre-trained Transformers with Large-scale PubMed Search Logs for Zero-shot Biomedical Information Retrievalcited by 185
- 2024Fact, Fetch, and Reason: A Unified Evaluation of Retrieval-Augmented Generationcited by 162
- 2019A Question-Entailment Approach to Question Answeringcited by 134
4 more
- 2025Medical Hallucinations in Foundation Models and Their Impact on Healthcarecited by 93
- 2024How well do LLMs cite relevant medical references? An evaluation framework and analysescited by 21
- 2024Towards Adapting Open-Source Large Language Models for Expert-Level Clinical Note Generationcited by 9
- 2025RAGXplain: From Explainable Evaluation to Actionable Guidance of RAG Pipelinescited by 4
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Citing papers per year: 2026: 2.
2 papers.
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Close in wording, no citation either way
- 2025Talk Before You Retrieve: Agent-Led Discussions for Better RAG in Medical QA
- 2025ASTRID -- An Automated and Scalable TRIaD for the Evaluation of RAG-based Clinical Question Answering Systems
- 2026When Retrieval Doesn't Help: A Large-Scale Study of Biomedical RAG
- 2025Optimizing Medical Question-Answering Systems: A Comparative Study of Fine-Tuned and Zero-Shot Large Language Models with RAG Framework
- 2026A Systematic Study of Retrieval Pipeline Design for Retrieval-Augmented Medical Question Answering
- 2026SEMA-RAG: A Self-Evolving Multi-Agent Retrieval-Augmented Generation Framework for Medical Reasoning
- 2023MKRAG: Medical Knowledge Retrieval Augmented Generation for Medical Question Answering
- 2024Rationale-Guided Retrieval Augmented Generation for Medical Question Answering