mlsanityData to 14 Oct 2026

Structure Matters: Evaluating Multi-Agents Orchestration in Generative Therapeutic Chatbots

arXiv 2603.00774 ↗First posted 28 Feb 2026cs.HCcited by 0

On the map: LLM agents and tool use → Medical and scientific domain agents

Abstract (arXiv)

While large language models (LLMs) excel at open-ended dialogue, effective psychotherapy requires structured progression and adherence to clinical protocols, making the design of psychotherapist chatbots challenging. We investigate how different LLM-based designs shape perceived therapeutic dialogue in a chatbot grounded in the Self-Attachment Technique (SAT), a novel self-administered psychotherapy rooted in attachment theory. We compare three architectural variants: (1) a multi-agent system utilizing finite state machine aligned with therapeutic stages and a shared long-term memory, (2) a single-agent using identical knowledge-base and the same prompts, and (3) an unguided LLM. In an eight-day randomized controlled trial (RCT) with N=66 Farsi-speaking participants, balanced across the three chatbots, the multi-agent system is perceived as significantly more natural and human-like than the other variants and achieves higher ratings across most other metrics. These findings demonstrate that for therapeutic AI, architectural orchestration is as critical as prompt engineering in fostering natural, engaging dialogue.

Key facts. No citing papers in the map yet (data through 14 Oct 2026). Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use. Builds on 21 of its 46 references that are in the map. First posted on arXiv 28 Feb 2026.

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21 of 46 references.

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  1. 2025HamRaz: A Culture-Based Persian Conversation Dataset for Person-Centered Therapy Using LLM Agents9 Feb

Other references · 20

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  5. 2023Facilitating Self-Guided Mental Health Interventions Through Human-Language Model Interaction: A Case Study of Cognitive Restructuringcited by 53
  6. 2023MindfulDiary: Harnessing Large Language Model to Support Psychiatric Patients' Journalingcited by 50
  7. 2023ChaCha: Leveraging Large Language Models to Prompt Children to Share Their Emotions about Personal Eventscited by 31
  8. 2024The Typing Cure: Experiences with Large Language Model Chatbots for Mental Health Supportcited by 24
  9. 2025MetaAgent: Automatically Constructing Multi-Agent Systems Based on Finite State Machinescited by 22
  10. 2025EmoAgent: Assessing and Safeguarding Human-AI Interaction for Mental Health Safetycited by 21
  11. 2021An Evaluation of Generative Pre-Training Model-based Therapy Chatbot for Caregiverscited by 15
  12. 2023PersianLLaMA: Towards Building First Persian Large Language Modelcited by 14
8 more
  1. 2024Private Yet Social: How LLM Chatbots Support and Challenge Eating Disorder Recoverycited by 8
  2. 2022An Empathetic AI Coach for Self-Attachment Therapycited by 5
  3. 2024Comparing the Efficacy of GPT-4 and Chat-GPT in Mental Health Care: A Blind Assessment of Large Language Models for Psychological Supportcited by 5
  4. 2025AgentMental: An Interactive Multi-Agent Framework for Explainable and Adaptive Mental Health Assessmentcited by 5
  5. 2024Can a Funny Chatbot Make a Difference? Infusing Humor into Conversational Agent for Behavioral Interventioncited by 4
  6. 2019A Deep Learning Based Chatbot for Campus Psychological Therapycited by 2
  7. 2023From Words and Exercises to Wellness: Farsi Chatbot for Self-Attachment Techniquecited by 2
  8. 2023A Multilingual Virtual Guide for Self-Attachment Techniquecited by 1

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