mlsanityData to 7 Oct 2026

A medical coding language model trained on clinical narratives from a population-wide cohort of 1.8 million patients

arXiv 2603.00221 ↗First posted 27 Feb 2026cs.LGcited by 1

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Abstract (arXiv)

Medical coding translates clinical documentation into standardized codes for billing, research, and public health, but manual coding is time-consuming and error-prone. Existing automation efforts rely on small datasets that poorly represent real-world patient heterogeneity. We trained a language model on 5.8 million electronic health records from 1.8 million patients across nearly all specialties in Eastern Denmark (2006--2016) to predict ICD-10 codes from clinical notes, medications, and laboratory results. Evaluated on 270,000 held-out patients, the model achieved a micro F1 of 71.8% and a top-10 recall of 95.5%. Performance varied by specialty (F1: 53--91%), with higher scores in specialties with well-defined diagnostic criteria. Codes appearing predominantly as secondary diagnoses had markedly lower F1 scores. For three such codes (suicide-related behaviors, weight disorders, and hypertension), the model identified thousands of uncoded cases, of which 76-86% were confirmed valid upon manual review, suggesting systematic under-coding rather than model error. These findings suggest under-coding of secondary diagnoses in Eastern Denmark during this period, with potential implications for epidemiological research, public health surveillance, and understanding of multimorbidity. Similar time constraints and reimbursement structures in other healthcare systems suggest this may not be isolated to this dataset. The model can automate coding for approximately 50% of cases and provide accurate suggestions for most others, and may offer a practical solution to help capture missed secondary conditions.

Key facts. Cited by 1 paper in the map (data through 7 Oct 2026). Builds on 7 of its 35 references that are in the map. First posted on arXiv 27 Feb 2026.

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7 of 35 references.

References · 7

  1. 2018Explainable Prediction of Medical Codes from Clinical Textcited by 231
  2. 2022PLM-ICD: Automatic ICD Coding with Pretrained Language Modelscited by 49
  3. 2023Automated Medical Coding on MIMIC-III and MIMIC-IV: A Critical Review and Replicability Studycited by 48
  4. 2022Automated Clinical Coding: What, Why, and Where We Are?cited by 33
  5. 2022A Unified Review of Deep Learning for Automated Medical Codingcited by 26
  6. 2024An Unsupervised Approach to Achieve Supervised-Level Explainability in Healthcare Recordscited by 12
  7. 2025Code Like Humans: A Multi-Agent Solution for Medical Codingcited by 10

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