DeFloMat: Detection with Flow Matching for Stable and Efficient Generative Object Localization

We propose DeFloMat (Detection with Flow Matching), a novel generative object detection framework that addresses the critical latency bottleneck of diffusion-based detectors, such as DiffusionDet, by integrating Conditional Flow Matching (CFM). Diffusion models achieve high accuracy by formulating detection as a multi-step stochastic denoising process, but their reliance on numerous sampling steps (T gg 60) makes them impractical for time-sensitive clinical applications like Crohn's Disease detection in Magnetic Resonance Enterography (MRE). DeFloMat replaces this slow stochastic path with a highly direct, deterministic flow field derived from Conditional Optimal Transport (OT) theory, specifically approximating the Rectified Flow. This shift enables fast inference via a simple Ordinary Differential Equation (ODE) solver. We demonstrate the superiority of DeFloMat on a challenging MRE clinical dataset. Crucially, DeFloMat achieves state-of-the-art accuracy (43.32% AP10:50) in only 3 inference steps, which represents a 1.4× performance improvement over DiffusionDet's maximum converged performance (31.03% AP10:50 at 4 steps). Furthermore, our deterministic flow significantly enhances localization characteristics, yielding superior Recall and stability in the few-step regime. DeFloMat resolves the trade-off between generative accuracy and clinical efficiency, setting a new standard for stable and rapid object localization.