mlsanityData to 7 Oct 2026

Generative AI for Healthcare: Fundamentals, Challenges, and Perspectives

arXiv 2510.24551 ↗First posted 28 Oct 2025cs.AIcited by 3

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Abstract (arXiv)

Generative Artificial Intelligence (GenAI) is taking the world by storm. It promises transformative opportunities for advancing and disrupting existing practices, including healthcare. From large language models (LLMs) for clinical note synthesis and conversational assistance to multimodal systems that integrate medical imaging, electronic health records, and genomic data for decision support, GenAI is transforming the practice of medicine and the delivery of healthcare, such as diagnosis and personalized treatments, with great potential in reducing the cognitive burden on clinicians, thereby improving overall healthcare delivery. However, GenAI deployment in healthcare requires an in-depth understanding of healthcare tasks and what can and cannot be achieved. In this paper, we propose a data-centric paradigm in the design and deployment of GenAI systems for healthcare. Specifically, we reposition the data life cycle by making the medical data ecosystem as the foundational substrate for generative healthcare systems. This ecosystem is designed to sustainably support the integration, representation, and retrieval of diverse medical data and knowledge. With effective and efficient data processing pipelines, such as semantic vector search and contextual querying, it enables GenAI-powered operations for upstream model components and downstream clinical applications. Ultimately, it not only supplies foundation models with high-quality, multimodal data for large-scale pretraining and domain-specific fine-tuning, but also serves as a knowledge retrieval backend to support task-specific inference via the agentic layer. The ecosystem enables the deployment of GenAI for high-quality and effective healthcare delivery.

Key facts. Cited by 3 papers in the map (data through 7 Oct 2026). Builds on 88 of its 130 references that are in the map. First posted on arXiv 28 Oct 2025.

Builds on

88 of 130 references.

References · 88

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Citing papers per year: 2026: 3.

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  1. 2024The Potential and Perils of Generative Artificial Intelligence for Quality Improvement and Patient Safety
  2. 2025From large language models to multimodal AI: A scoping review on the potential of generative AI in medicine
  3. 2023Recent Advances in Generative AI for Healthcare Applications
  4. 2024Can Generative AI Support Patients' & Caregivers' Informational Needs? Towards Task-Centric Evaluation Of AI Systems
  5. 2024Generative AI in Health Economics and Outcomes Research: A Taxonomy of Key Definitions and Emerging Applications, an ISPOR Working Group Report
  6. 2025Grounded by Experience: Generative Healthcare Prediction Augmented with Hierarchical Agentic Retrieval
  7. 2024The Minimum Information about CLinical Artificial Intelligence Checklist for Generative Modeling Research (MI-CLAIM-GEN)
  8. 2025Generative Artificial Intelligence in Medical Imaging: Foundations, Progress, and Clinical Translation