Multimodal Prompt Optimization: Why Not Leverage Multiple Modalities for MLLMs
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Abstract (arXiv)
Large Language Models (LLMs) have shown remarkable success, and their multimodal expansions (MLLMs) further unlock capabilities spanning images, videos, and other modalities beyond text. However, despite this shift, prompt optimization approaches, designed to reduce the burden of manual prompt crafting while maximizing performance, remain confined to text, ultimately limiting the full potential of MLLMs. Motivated by this gap, we introduce the new problem of multimodal prompt optimization, which expands the prior definition of prompt optimization to the multimodal space defined by the pairs of textual and non-textual prompts. To tackle this problem, we then propose the Multimodal Prompt Optimizer (MPO), a unified framework that not only performs the joint optimization of multimodal prompts through alignment-preserving updates but also guides the selection process of candidate prompts by leveraging earlier evaluations as priors in a Bayesian-based selection strategy. Through extensive experiments across diverse modalities that go beyond text, such as images, videos, and even molecules, we demonstrate that MPO outperforms leading text-only optimization methods, establishing multimodal prompt optimization as a crucial step to realizing the potential of MLLMs.
Key facts. Cited by 5 papers in the map (data through 7 Oct 2026). Builds on 39 of its 60 references that are in the map. First posted on arXiv 10 Oct 2025.
Builds on
39 of 60 references.
References · 39
- 2022Chain-of-Thought Prompting Elicits Reasoning in Large Language Modelscited by 12,302
- 2023Visual Instruction Tuningcited by 7,792
- 2025Qwen2.5-VL Technical Reportcited by 5,418
- 2025Gemini 2.5: Pushing the Frontier with Advanced Reasoning, Multimodality, Long Context, and Next Generation Agentic Capabilitiescited by 3,655
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- 2022Large Language Models Are Human-Level Prompt Engineerscited by 1,020
- 2023Large Language Models as Optimizerscited by 830
- 2023DSPy: Compiling Declarative Language Model Calls into Self-Improving Pipelinescited by 803
- 2023Multimodal Chain-of-Thought Reasoning in Language Modelscited by 740
- 2022MaPLe: Multi-modal Prompt Learningcited by 685
- 2023Automatic Prompt Optimization with "Gradient Descent" and Beam Searchcited by 628
27 more
- 2023ChemCrow: Augmenting large-language models with chemistry toolscited by 609
- 2023Qwen-Audio: Advancing Universal Audio Understanding via Unified Large-Scale Audio-Language Modelscited by 591
- 2023Promptbreeder: Self-Referential Self-Improvement Via Prompt Evolutioncited by 521
- 2021SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answeringcited by 444
- 2021Therapeutics Data Commons: Machine Learning Datasets and Tasks for Drug Discovery and Developmentcited by 258
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- 2023Davidsonian Scene Graph: Improving Reliability in Fine-grained Evaluation for Text-to-Image Generationcited by 159
- 2024Improving Text-to-Image Consistency via Automatic Prompt Optimizationcited by 88
- 2024Image-of-Thought Prompting for Visual Reasoning Refinement in Multimodal Large Language Modelscited by 64
- 2025A Systematic Survey of Automatic Prompt Optimization Techniquescited by 61
- 2023Prompt Engineering a Prompt Engineercited by 53
- 2024Dynamic Prompt Optimizing for Text-to-Image Generationcited by 45
- 2025A Survey of Automatic Prompt Engineering: An Optimization Perspectivecited by 41
- 2024Efficient Prompt Optimization Through the Lens of Best Arm Identificationcited by 35
- 2024SPRIG: Improving Large Language Model Performance by System Prompt Optimizationcited by 28
- 2024Large Language Models in Drug Discovery and Development: From Disease Mechanisms to Clinical Trialscited by 24
- 2025The Devil is in the Prompts: Retrieval-Augmented Prompt Optimization for Text-to-Video Generationcited by 21
- 2024VANE-Bench: Video Anomaly Evaluation Benchmark for Conversational LMMscited by 20
- 2025System Prompt Optimization with Meta-Learningcited by 18
- 2024Joint Visual and Text Prompting for Improved Object-Centric Perception with Multimodal Large Language Modelscited by 16
- 2024M2PT: Multimodal Prompt Tuning for Zero-shot Instruction Learningcited by 16
- 2025Mol-LLaMA: Towards General Understanding of Molecules in Large Molecular Language Modelcited by 16
- 2024Rethinking Visual Prompting for Multimodal Large Language Models with External Knowledgecited by 13
- 2024SEE: Strategic Exploration and Exploitation for Cohesive In-Context Prompt Optimizationcited by 12
- 2025Bandit-Based Prompt Design Strategy Selection Improves Prompt Optimizerscited by 7
- 2025Survey: Multi-Armed Bandits Meet Large Language Modelscited by 6
Built on by
Citing papers per year: 2026: 5.
5 papers.
- 2026The Last AI Built by Humans: Toward Genuine Recursive Self-Improvementcited by 5
- 2026Learning from Prompt itself: the Hierarchical Attribution Prompt Optimizationcited by 1
- 2026ArtifactLens: Hundreds of Labels Are Enough for Artifact Detection with VLMscited by 1
- 2026Visual Persuasion: What Influences Decisions of Vision-Language Models?cited by 1
- 2026Are Prompt Optimizers Blind? Cross-Modal Visual Feedback for Automatic Prompt Optimizationcited by 1
- 2026The Last AI Built by Humans: Toward Genuine Recursive Self-Improvement10 Sep 2026
- 2026Are Prompt Optimizers Blind? Cross-Modal Visual Feedback for Automatic Prompt Optimization27 Jul 2026
- 2026Visual Persuasion: What Influences Decisions of Vision-Language Models?17 Feb 2026
- 2026ArtifactLens: Hundreds of Labels Are Enough for Artifact Detection with VLMs10 Feb 2026
- 2026Learning from Prompt itself: the Hierarchical Attribution Prompt Optimization6 Jan 2026
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- 2025The Future of MLLM Prompting is Adaptive: A Comprehensive Experimental Evaluation of Prompt Engineering Methods for Robust Multimodal Performance
- 2026MAF: Multimodal Adaptive Few-shot Prompting for Sentiment Analysis with MLLMs
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- 2024POEM: Interactive Prompt Optimization for Enhancing Multimodal Reasoning of Large Language Models
- 2025RAPO++: Cross-Stage Prompt Optimization for Text-to-Video Generation via Data Alignment and Test-Time Scaling