Haibu Mathematical-Medical Intelligent Agent:Enhancing Large Language Model Reliability in Medical Tasks via Verifiable Reasoning Chains
On the map: LLM reasoning → Clinical and biomedical applications
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Abstract (arXiv)
Large Language Models (LLMs) show promise in medicine but are prone to factual and logical errors, which is unacceptable in this high-stakes field. To address this, we introduce the "Haibu Mathematical-Medical Intelligent Agent" (MMIA), an LLM-driven architecture that ensures reliability through a formally verifiable reasoning process. MMIA recursively breaks down complex medical tasks into atomic, evidence-based steps. This entire reasoning chain is then automatically audited for logical coherence and evidence traceability, similar to theorem proving. A key innovation is MMIA's "bootstrapping" mode, which stores validated reasoning chains as "theorems." Subsequent tasks can then be efficiently solved using Retrieval-Augmented Generation (RAG), shifting from costly first-principles reasoning to a low-cost verification model. We validated MMIA across four healthcare administration domains, including DRG/DIP audits and medical insurance adjudication, using expert-validated benchmarks. Results showed MMIA achieved an error detection rate exceeding 98% with a false positive rate below 1%, significantly outperforming baseline LLMs. Furthermore, the RAG matching mode is projected to reduce average processing costs by approximately 85% as the knowledge base matures. In conclusion, MMIA's verifiable reasoning framework is a significant step toward creating trustworthy, transparent, and cost-effective AI systems, making LLM technology viable for critical applications in medicine.
Key facts. No citing papers in the map yet (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 4 of its 79 references that are in the map. First posted on arXiv 9 Oct 2025.
Builds on
4 of 79 references.
References · 4
- 2023Self-Refine: Iterative Refinement with Self-Feedbackcited by 3,442
- 2024A Survey on Retrieval-Augmented Text Generation for Large Language Modelscited by 77
- 2025Large Language Models Are Better Logical Fallacy Reasoners with Counterargument, Explanation, and Goal-Aware Prompt Formulationcited by 10
- 2025Large Language Models in Healthcarecited by 6
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- 2023Large Language Models Illuminate a Progressive Pathway to Artificial Healthcare Assistant: A Review
- 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning
- 2025A Survey of LLM-based Agents in Medicine: How far are we from Baymax?
- 2024Adaptive Reasoning and Acting in Medical Language Agents
- 2024Critique of Impure Reason: Unveiling the reasoning behaviour of medical Large Language Models
- 2026MedZERO: Self-Evolving Agents for Open-Ended Medical Reasoning Through Controlled Knowledge Accumulation