mlsanityData to 14 Oct 2026

Compartmentalised Agentic Reasoning for Clinical NLI

arXiv 2509.10222 ↗First posted 12 Sep 2025cs.AIcited by 0

On the map: LLM reasoning → Clinical and biomedical applications

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Abstract (arXiv)

Large language models can produce fluent judgments for clinical natural language inference, yet they frequently fail when the decision requires the correct inferential schema rather than surface matching. We introduce CARENLI, a compartmentalised agentic framework that routes each premise-statement pair to a reasoning family and then applies a specialised solver with explicit verification and targeted refinement. We evaluate on an expanded CTNLI benchmark of 200 instances spanning four reasoning families: Causal Attribution, Compositional Grounding, Epistemic Verification, and Risk State Abstraction. Across four contemporary backbone models, CARENLI improves mean accuracy from about 23% with direct prompting to about 57%, a gain of roughly 34 points, with the largest benefits on structurally demanding reasoning types. These results support compartmentalisation plus verification as a practical route to more reliable and auditable clinical inference.

Key facts. No citing papers in the map yet (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 15 of its 47 references that are in the map. First posted on arXiv 12 Sep 2025.

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15 of 47 references.

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Same direction, newest first

  1. 2025The Knowledge-Reasoning Dissociation: Fundamental Limitations of LLMs in Clinical Natural Language Inference14 Aug

Other references · 14

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  4. 2024GPT-4o System Cardcited by 4,588
  5. 2022Training Compute-Optimal Large Language Modelscited by 3,019
  6. 2023Sparks of Artificial General Intelligence: Early experiments with GPT-4cited by 2,592
  7. 2016Concrete Problems in AI Safetycited by 1,642
  8. 2018Annotation Artifacts in Natural Language Inference Datacited by 671
  9. 2018Hypothesis Only Baselines in Natural Language Inferencecited by 295
  10. 2018Lessons from Natural Language Inference in the Clinical Domaincited by 151
  11. 2024SemEval-2024 Task 2: Safe Biomedical Natural Language Inference for Clinical Trialscited by 20
  12. 2025Large language models provide unsafe answers to patient-posed medical questionscited by 18
2 more
  1. 2024Enhancing Ethical Explanations of Large Language Models through Iterative Symbolic Refinementcited by 16
  2. 2025Preventing Another Tessa: Modular Safety Middleware For Health-Adjacent AI Assistantscited by 3

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