mlsanityData to 14 Oct 2026

Extracting OPQRST in Electronic Health Records using Large Language Models with Reasoning

arXiv 2509.01885 ↗First posted 2 Sep 2025cs.CL cs.AIcited by 0

On the map: LLM reasoning → Clinical and biomedical applications

Abstract (arXiv)

The extraction of critical patient information from Electronic Health Records (EHRs) poses significant challenges due to the complexity and unstructured nature of the data. Traditional machine learning approaches often fail to capture pertinent details efficiently, making it difficult for clinicians to utilize these tools effectively in patient care. This paper introduces a novel approach to extracting the OPQRST assessment from EHRs by leveraging the capabilities of Large Language Models (LLMs). We propose to reframe the task from sequence labeling to text generation, enabling the models to provide reasoning steps that mimic a physician's cognitive processes. This approach enhances interpretability and adapts to the limited availability of labeled data in healthcare settings. Furthermore, we address the challenge of evaluating the accuracy of machine-generated text in clinical contexts by proposing a modification to traditional Named Entity Recognition (NER) metrics. This includes the integration of semantic similarity measures, such as the BERT Score, to assess the alignment between generated text and the clinical intent of the original records. Our contributions demonstrate a significant advancement in the use of AI in healthcare, offering a scalable solution that improves the accuracy and usability of information extraction from EHRs, thereby aiding clinicians in making more informed decisions and enhancing patient care outcomes.

Key facts. No citing papers in the map yet (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 7 of its 22 references that are in the map. First posted on arXiv 2 Sep 2025.

Builds on

7 of 22 references.

References · 7

  1. 2023GPT-4 Technical Reportcited by 18,396
  2. 2023Llama 2: Open Foundation and Fine-Tuned Chat Modelscited by 13,028
  3. 2021Prefix-Tuning: Optimizing Continuous Prompts for Generationcited by 3,915
  4. 2023GPT-NER: Named Entity Recognition via Large Language Modelscited by 160
  5. 2019Learning from Dialogue after Deployment: Feed Yourself, Chatbot!cited by 102
  6. 2018Few-shot Learning for Named Entity Recognition in Medical Textcited by 19
  7. 2023How far is Language Model from 100% Few-shot Named Entity Recognition in Medical Domaincited by 14

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  2. 2025EHRStruct: A Comprehensive Benchmark Framework for Evaluating Large Language Models on Structured Electronic Health Record Tasks
  3. 2026ChatHealthAI: Aligning Electronic Health Record Representations with Large Language Models for Grounded Clinical Reasoning
  4. 2025Leveraging LLMs for Structured Data Extraction from Unstructured Patient Records
  5. 2024Distilling Large Language Models for Efficient Clinical Information Extraction
  6. 2025EHR-R1: A Reasoning-Enhanced Foundational Language Model for Electronic Health Record Analysis
  7. 2024LLMs are not Zero-Shot Reasoners for Biomedical Information Extraction
  8. 2024PrecLLM: A Privacy-Preserving Framework for Efficient Clinical Annotation Extraction from Unstructured EHRs using Small-Scale LLMs