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A Human-Centered Approach to Identifying Promises, Risks, & Challenges of Text-to-Image Generative AI in Radiology

arXiv 2507.16207 ↗First posted 22 Jul 2025cs.HC cs.AI cs.CYcited by 0

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Abstract (arXiv)

As text-to-image generative models rapidly improve, AI researchers are making significant advances in developing domain-specific models capable of generating complex medical imagery from text prompts. Despite this, these technical advancements have overlooked whether and how medical professionals would benefit from and use text-to-image generative AI (GenAI) in practice. By developing domain-specific GenAI without involving stakeholders, we risk the potential of building models that are either not useful or even more harmful than helpful. In this paper, we adopt a human-centered approach to responsible model development by involving stakeholders in evaluating and reflecting on the promises, risks, and challenges of a novel text-to-CT Scan GenAI model. Through exploratory model prompting activities, we uncover the perspectives of medical students, radiology trainees, and radiologists on the role that text-to-CT Scan GenAI can play across medical education, training, and practice. This human-centered approach additionally enabled us to surface technical challenges and domain-specific risks of generating synthetic medical images. We conclude by reflecting on the implications of medical text-to-image GenAI.

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References · 17

  1. 2021Zero-Shot Text-to-Image Generationcited by 4,288
  2. 2024Evaluating Text-to-Visual Generation with Image-to-Text Generationcited by 474
  3. 2022Easily Accessible Text-to-Image Generation Amplifies Demographic Stereotypes at Large Scalecited by 262
  4. 2023VIEScore: Towards Explainable Metrics for Conditional Image Synthesis Evaluationcited by 201
  5. 2023Social Biases through the Text-to-Image Generation Lenscited by 127
  6. 2024CT2Rep: Automated Radiology Report Generation for 3D Medical Imagingcited by 96
  7. 2023GenerateCT: Text-Conditional Generation of 3D Chest CT Volumescited by 64
  8. 2024Design Principles for Generative AI Applicationscited by 57
  9. 2024Multimodal Healthcare AI: Identifying and Designing Clinically Relevant Vision-Language Applications for Radiologycited by 45
  10. 2023RadEdit: stress-testing biomedical vision models via diffusion image editingcited by 28
  11. 2024Supporting Sensemaking of Large Language Model Outputs at Scalecited by 27
  12. 2025WeAudit: Scaffolding User Auditors and AI Practitioners in Auditing Generative AIcited by 14
5 more
  1. 2022On the Horizon: Interactive and Compositional Deepfakescited by 13
  2. 2023Next Steps for Human-Centered Generative AI: A Technical Perspectivecited by 13
  3. 2024Medical Image Synthesis via Fine-Grained Image-Text Alignment and Anatomy-Pathology Promptingcited by 10
  4. 2024A Survey on Responsible Generative AI: What to Generate and What Notcited by 8
  5. 2024When Two Wrongs Don't Make a Right" -- Examining Confirmation Bias and the Role of Time Pressure During Human-AI Collaboration in Computational Pathologycited by 2

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