Active Learning Inspired ControlNet Guidance for Augmenting Semantic Segmentation Datasets
On the map: Diffusion models → Medical imaging and segmentation
Abstract (arXiv)
Recent advances in conditional image generation from diffusion models have shown great potential in achieving impressive image quality while preserving the constraints introduced by the user. In particular, ControlNet enables precise alignment between ground truth segmentation masks and the generated image content, allowing the enhancement of training datasets in segmentation tasks. This raises a key question: Can ControlNet additionally be guided to generate the most informative synthetic samples for a specific task? Inspired by active learning, where the most informative real-world samples are selected based on sample difficulty or model uncertainty, we propose the first approach to integrate active learning-based selection metrics into the backward diffusion process for sample generation. Specifically, we explore uncertainty, query by committee, and expected model change, which are commonly used in active learning, and demonstrate their application for guiding the sample generation process through gradient approximation. Our method is training-free, modifying only the backward diffusion process, allowing it to be used on any pretrained ControlNet. Using this process, we show that segmentation models trained with guided synthetic data outperform those trained on non-guided synthetic data. Our work underscores the need for advanced control mechanisms for diffusion-based models, which are not only aligned with image content but additionally downstream task performance, highlighting the true potential of synthetic data generation.
Key facts. Cited by 2 papers in the map (data through 7 Oct 2026). Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models. Builds on 44 of its 63 references that are in the map. First posted on arXiv 12 Mar 2025.
Builds on
44 of 63 references.
Closest ancestors · 3
Same direction, newest first
- 2023DGInStyle: Domain-Generalizable Semantic Segmentation with Image Diffusion Models and Stylized Semantic Control5 Dec
- 2023ScribbleGen: Generative Data Augmentation Improves Scribble-supervised Semantic Segmentation28 Nov
- 2023DiffuMask: Synthesizing Images with Pixel-level Annotations for Semantic Segmentation Using Diffusion Models21 Mar
Other references · 41
- 2021Learning Transferable Visual Models From Natural Language Supervisioncited by 33,456
- 2021High-Resolution Image Synthesis with Latent Diffusion Modelscited by 18,694
- 2020Denoising Diffusion Implicit Modelscited by 9,655
- 2021Diffusion Models Beat GANs on Image Synthesiscited by 8,185
- 2022Photorealistic Text-to-Image Diffusion Models with Deep Language Understandingcited by 6,322
- 2022Classifier-Free Diffusion Guidancecited by 5,717
- 2023Adding Conditional Control to Text-to-Image Diffusion Modelscited by 5,466
- 2015Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learningcited by 4,416
- 2023SDXL: Improving Latent Diffusion Models for High-Resolution Image Synthesiscited by 4,290
- 2021Zero-Shot Text-to-Image Generationcited by 4,276
- 2016COCO-Stuff: Thing and Stuff Classes in Contextcited by 858
- 2023Attend-and-Excite: Attention-Based Semantic Guidance for Text-to-Image Diffusion Modelscited by 696
29 more
- 2020A Survey of Deep Active Learningcited by 547
- 2022Training-Free Structured Diffusion Guidance for Compositional Text-to-Image Synthesiscited by 386
- 2023Synthetic Data from Diffusion Models Improves ImageNet Classificationcited by 326
- 2023Training-Free Layout Control with Cross-Attention Guidancecited by 312
- 2022SegNeXt: Rethinking Convolutional Attention Design for Semantic Segmentationcited by 252
- 2023Better Diffusion Models Further Improve Adversarial Trainingcited by 207
- 2021How Faithful is your Synthetic Data? Sample-level Metrics for Evaluating and Auditing Generative Modelscited by 193
- 2022Fake it till you make it: Learning transferable representations from synthetic ImageNet clonescited by 171
- 2017Suggestive Annotation: A Deep Active Learning Framework for Biomedical Image Segmentationcited by 145
- 2023Dataset Diffusion: Diffusion-based Synthetic Dataset Generation for Pixel-Level Semantic Segmentationcited by 112
- 2023Diffusion Models for Imperceptible and Transferable Adversarial Attackcited by 93
- 2021Multiple instance active learning for object detectioncited by 77
- 2018Efficient Active Learning for Image Classification and Segmentation using a Sample Selection and Conditional Generative Adversarial Networkcited by 74
- 2023Content-based Unrestricted Adversarial Attackcited by 73
- 2024SynthCLIP: Are We Ready for a Fully Synthetic CLIP Training?cited by 64
- 2021Towards Fewer Annotations: Active Learning via Region Impurity and Prediction Uncertainty for Domain Adaptive Semantic Segmentationcited by 56
- 2023AdvDiff: Generating Unrestricted Adversarial Examples using Diffusion Modelscited by 46
- 2020DEAL: Difficulty-aware Active Learning for Semantic Segmentationcited by 32
- 2023Divide, Evaluate, and Refine: Evaluating and Improving Text-to-Image Alignment with Iterative VQA Feedbackcited by 31
- 2022Plug and Play Active Learning for Object Detectioncited by 28
- 2024DataDream: Few-shot Guided Dataset Generationcited by 28
- 2024Dataset Enhancement with Instance-Level Augmentationscited by 23
- 2025Predictive Data Selection: The Data That Predicts Is the Data That Teachescited by 20
- 2024Deep Bayesian Active Learning for Preference Modeling in Large Language Modelscited by 19
- 2023SegGen: Supercharging Segmentation Models with Text2Mask and Mask2Img Synthesiscited by 18
- 2024DiverGen: Improving Instance Segmentation by Learning Wider Data Distribution with More Diverse Generative Datacited by 15
- 2020Synthetic Sample Selection via Reinforcement Learningcited by 13
- 2023Bridging the Gap: Enhancing the Utility of Synthetic Data via Post-Processing Techniquescited by 11
- 2024Generative Active Learning for Long-tailed Instance Segmentationcited by 10
Built on by
Citing papers per year: 2026: 2.
2 papers.
Similar, not cited
Close in wording, no citation either way
- 2025Diffusion-Driven Two-Stage Active Learning for Low-Budget Semantic Segmentation
- 2025Uncertainty-Aware ControlNet: Bridging Domain Gaps with Synthetic Image Generation
- 2023Exploring Limits of Diffusion-Synthetic Training with Weakly Supervised Semantic Segmentation
- 2026R&D: Balancing Reliability and Diversity in Synthetic Data Augmentation for Semantic Segmentation
- 2024Enhanced Generative Data Augmentation for Semantic Segmentation via Stronger Guidance
- 2021Label-Efficient Semantic Segmentation with Diffusion Models
- 2024Hybrid diffusion models: combining supervised and generative pretraining for label-efficient fine-tuning of segmentation models
- 2026Diffusion Model as a Generalist Segmentation Learner