Path-SAM2: Transfer SAM2 for digital pathology semantic segmentation

The semantic segmentation task in pathology plays an indispensable role in assisting physicians in determining the condition of tissue lesions. With the proposal of Segment Anything Model (SAM), more and more foundation models have seen rapid development in the field of image segmentation. Recently, SAM2 has garnered widespread attention in both natural image and medical image segmentation. Compared to SAM, it has significantly improved in terms of segmentation accuracy and generalization performance. We compared the foundational models based on SAM and found that their performance in semantic segmentation of pathological images was hardly satisfactory. In this paper, we propose Path-SAM2, which for the first time adapts the SAM2 model to cater to the task of pathological semantic segmentation. We integrate the largest pretrained vision encoder for histopathology (UNI) with the original SAM2 encoder, adding more pathology-based prior knowledge. Additionally, we introduce a learnable Kolmogorov-Arnold Networks (KAN) classification module to replace the manual prompt process. In three adenoma pathological datasets, Path-SAM2 has achieved state-of-the-art performance.This study demonstrates the great potential of adapting SAM2 to pathology image segmentation tasks. We plan to release the code and model weights for this paper at: https://github.com/simzhangbest/SAM2PATH