OLAPH: Improving Factuality in Biomedical Long-form Question Answering
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Abstract (arXiv)
In the medical domain, numerous scenarios necessitate the long-form generation ability of large language models (LLMs). Specifically, when addressing patients' questions, it is essential that the model's response conveys factual claims, highlighting the need for an automated method to evaluate those claims. Thus, we introduce MedLFQA, a benchmark dataset reconstructed using long-form question-answering datasets related to the biomedical domain. We use MedLFQA to facilitate a cost-effective automatic evaluations of factuality. We also propose OLAPH, a simple and novel framework that utilizes cost-effective and multifaceted automatic evaluation to construct a synthetic preference set and answers questions in our preferred manner. Our framework leads us to train LLMs step-by-step to reduce hallucinations and include crucial medical claims. We highlight that, even on evaluation metrics not used during training, LLMs trained with our OLAPH framework demonstrate significant performance improvement in factuality. Our findings reveal that a 7B LLM trained with our OLAPH framework can provide long answers comparable to the medical experts' answers in terms of factuality. We believe that our work could shed light on gauging the long-text generation ability of LLMs in the medical domain. Our code and datasets are available.
Key facts. Cited by 20 papers in the map (data through 7 Oct 2026). Builds on 63 of its 75 references that are in the map. First posted on arXiv 21 May 2024.
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- 2024Large language model validity via enhanced conformal prediction methodscited by 91
- 2025Mask-DPO: Generalizable Fine-grained Factuality Alignment of LLMscited by 22
- 2025Automatic Evaluation of Healthcare LLMs Beyond Question-Answeringcited by 19
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- 2026OpenBioRQ: Unsolved Biomedical Research Questions for Agentscited by 0
- 2026Two-Level Meta-Rubrics for Evaluating Open-Ended Generation: GAMUT, a Benchmark for Factual Completeness21 Jul 2026
- 2026Breaking Failure Cascades: Step-Aware Reinforcement Learning for Medical Multimodal Reasoning30 Jun 2026
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- 2026Multi-LLM Adaptive Conformal Inference for Reliable LLM Responses1 Feb 2026
- 2025MedBioRAG: Semantic Search and Retrieval-Augmented Generation with Large Language Models for Medical and Biological QA10 Dec 2025
- 2025Understanding the Effects of Domain Finetuning on LLMs10 Oct 2025
- 2025Harnessing RLHF for Robust Unanswerability Recognition and Trustworthy Response Generation in LLMs22 Jul 2025
- 2025Response Quality Assessment for Retrieval-Augmented Generation via Conditional Conformal Factuality26 Jun 2025
- 2025Large Language Models for Cancer Communication: Evaluating Linguistic Quality, Safety, and Accessibility in Generative AI15 May 2025
- 2025Benchmarking Large Language Models on Multiple Tasks in Bioinformatics NLP with Prompting6 Mar 2025
- 2025Structured Outputs Enable General-Purpose LLMs to be Medical Experts5 Mar 2025
8 more
- 2025Mask-DPO: Generalizable Fine-grained Factuality Alignment of LLMs4 Mar 2025
- 2025Automatic Evaluation of Healthcare LLMs Beyond Question-Answering10 Feb 2025
- 2025MedBioLM: Optimizing Medical and Biological QA with Fine-Tuned Large Language Models and Retrieval-Augmented Generation5 Feb 2025
- 2025EvidenceMap: Learning Evidence Analysis to Unleash the Power of Small Language Models for Biomedical Question Answering22 Jan 2025
- 2024Culinary Class Wars: Evaluating LLMs using ASH in Cuisine Transfer Task4 Nov 2024
- 2024HALO: Hallucination Analysis and Learning Optimization to Empower LLMs with Retrieval-Augmented Context for Guided Clinical Decision Making16 Sep 2024
- 2024LLMs are not Zero-Shot Reasoners for Biomedical Information Extraction22 Aug 2024
- 2024Large language model validity via enhanced conformal prediction methods14 Jun 2024
- 2025Response Quality Assessment for Retrieval-Augmented Generation via Conditional Conformal Factualitycited by 8
- 2025MedBioLM: Optimizing Medical and Biological QA with Fine-Tuned Large Language Models and Retrieval-Augmented Generationcited by 5
- 2024HALO: Hallucination Analysis and Learning Optimization to Empower LLMs with Retrieval-Augmented Context for Guided Clinical Decision Makingcited by 3
- 2025MedBioRAG: Semantic Search and Retrieval-Augmented Generation with Large Language Models for Medical and Biological QAcited by 1
- 2025MedBioRAG: Semantic Search and Retrieval-Augmented Generation with Large Language Models for Medical and Biological QA10 Dec 2025
- 2025Response Quality Assessment for Retrieval-Augmented Generation via Conditional Conformal Factuality26 Jun 2025
- 2025MedBioLM: Optimizing Medical and Biological QA with Fine-Tuned Large Language Models and Retrieval-Augmented Generation5 Feb 2025
- 2024HALO: Hallucination Analysis and Learning Optimization to Empower LLMs with Retrieval-Augmented Context for Guided Clinical Decision Making16 Sep 2024
- 2026OpenBioRQ: Unsolved Biomedical Research Questions for Agents20 Jun 2026
- 2024Large language model validity via enhanced conformal prediction methodscited by 91
- 2025Automatic Evaluation of Healthcare LLMs Beyond Question-Answeringcited by 19
- 2025Benchmarking Large Language Models on Multiple Tasks in Bioinformatics NLP with Promptingcited by 8
- 2025Structured Outputs Enable General-Purpose LLMs to be Medical Expertscited by 6
- 2026Conformal Policy Controlcited by 5
- 2025Understanding the Effects of Domain Finetuning on LLMscited by 4
- 2026Two-Level Meta-Rubrics for Evaluating Open-Ended Generation: GAMUT, a Benchmark for Factual Completenesscited by 2
- 2025EvidenceMap: Learning Evidence Analysis to Unleash the Power of Small Language Models for Biomedical Question Answeringcited by 1
- 2025Large Language Models for Cancer Communication: Evaluating Linguistic Quality, Safety, and Accessibility in Generative AIcited by 1
- 2026Multi-LLM Adaptive Conformal Inference for Reliable LLM Responsescited by 1
- 2024Culinary Class Wars: Evaluating LLMs using ASH in Cuisine Transfer Taskcited by 0
- 2026Two-Level Meta-Rubrics for Evaluating Open-Ended Generation: GAMUT, a Benchmark for Factual Completeness21 Jul 2026
- 2026Conformal Policy Control2 Mar 2026
- 2026Multi-LLM Adaptive Conformal Inference for Reliable LLM Responses1 Feb 2026
- 2025Understanding the Effects of Domain Finetuning on LLMs10 Oct 2025
- 2025Large Language Models for Cancer Communication: Evaluating Linguistic Quality, Safety, and Accessibility in Generative AI15 May 2025
- 2025Benchmarking Large Language Models on Multiple Tasks in Bioinformatics NLP with Prompting6 Mar 2025
- 2025Structured Outputs Enable General-Purpose LLMs to be Medical Experts5 Mar 2025
- 2025Automatic Evaluation of Healthcare LLMs Beyond Question-Answering10 Feb 2025
- 2025EvidenceMap: Learning Evidence Analysis to Unleash the Power of Small Language Models for Biomedical Question Answering22 Jan 2025
- 2024Culinary Class Wars: Evaluating LLMs using ASH in Cuisine Transfer Task4 Nov 2024
- 2024Large language model validity via enhanced conformal prediction methods14 Jun 2024