mlsanityData to 7 Oct 2026

OLAPH: Improving Factuality in Biomedical Long-form Question Answering

arXiv 2405.12701 ↗First posted 21 May 2024cs.CL cs.AIcited by 20

Not on the map. Why?

Abstract (arXiv)

In the medical domain, numerous scenarios necessitate the long-form generation ability of large language models (LLMs). Specifically, when addressing patients' questions, it is essential that the model's response conveys factual claims, highlighting the need for an automated method to evaluate those claims. Thus, we introduce MedLFQA, a benchmark dataset reconstructed using long-form question-answering datasets related to the biomedical domain. We use MedLFQA to facilitate a cost-effective automatic evaluations of factuality. We also propose OLAPH, a simple and novel framework that utilizes cost-effective and multifaceted automatic evaluation to construct a synthetic preference set and answers questions in our preferred manner. Our framework leads us to train LLMs step-by-step to reduce hallucinations and include crucial medical claims. We highlight that, even on evaluation metrics not used during training, LLMs trained with our OLAPH framework demonstrate significant performance improvement in factuality. Our findings reveal that a 7B LLM trained with our OLAPH framework can provide long answers comparable to the medical experts' answers in terms of factuality. We believe that our work could shed light on gauging the long-text generation ability of LLMs in the medical domain. Our code and datasets are available.

Key facts. Cited by 20 papers in the map (data through 7 Oct 2026). Builds on 63 of its 75 references that are in the map. First posted on arXiv 21 May 2024.

Builds on

63 of 75 references.

References · 63

  1. 2019PyTorch: An Imperative Style, High-Performance Deep Learning Librarycited by 20,160
  2. 2022Training language models to follow instructions with human feedbackcited by 15,712
  3. 2023Llama 2: Open Foundation and Fine-Tuned Chat Modelscited by 12,865
  4. 2023Direct Preference Optimization: Your Language Model is Secretly a Reward Modelcited by 7,916
  5. 2020Measuring Massive Multitask Language Understandingcited by 7,768
  6. 2023Efficient Memory Management for Large Language Model Serving with PagedAttentioncited by 5,767
  7. 2019BERTScore: Evaluating Text Generation with BERTcited by 5,462
  8. 2017On Calibration of Modern Neural Networkscited by 4,860
  9. 2020Dense Passage Retrieval for Open-Domain Question Answeringcited by 3,779
  10. 2022FlashAttention: Fast and Memory-Efficient Exact Attention with IO-Awarenesscited by 3,611
  11. 2023Mistral 7Bcited by 3,065
  12. 2021TruthfulQA: Measuring How Models Mimic Human Falsehoodscited by 2,919
38 more
  1. 2017A Broad-Coverage Challenge Corpus for Sentence Understanding through Inferencecited by 2,665
  2. 2023G-Eval: NLG Evaluation using GPT-4 with Better Human Alignmentcited by 2,205
  3. 2019HuggingFace's Transformers: State-of-the-art Natural Language Processingcited by 2,201
  4. 2019BioBERT: a pre-trained biomedical language representation model for biomedical text miningcited by 1,935
  5. 2015A large annotated corpus for learning natural language inferencecited by 1,837
  6. 2022Large Language Models Encode Clinical Knowledgecited by 1,807
  7. 2022Language Models (Mostly) Know What They Knowcited by 1,783
  8. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
  9. 2019ZeRO: Memory Optimizations Toward Training Trillion Parameter Modelscited by 1,278
  10. 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,271
  11. 2023FActScore: Fine-grained Atomic Evaluation of Factual Precision in Long Form Text Generationcited by 1,259
  12. 2023Inference-Time Intervention: Eliciting Truthful Answers from a Language Modelcited by 1,259
  13. 2020BLEURT: Learning Robust Metrics for Text Generationcited by 1,196
  14. 2023Large Language Modelscited by 774
  15. 2023MetaMath: Bootstrap Your Own Mathematical Questions for Large Language Modelscited by 724
  16. 2023Capabilities of GPT-4 on Medical Challenge Problemscited by 630
  17. 2019ELI5: Long Form Question Answeringcited by 567
  18. 2024Self-Play Fine-Tuning Converts Weak Language Models to Strong Language Modelscited by 552
  19. 2022MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answeringcited by 525
  20. 2021SummaC: Re-Visiting NLI-based Models for Inconsistency Detection in Summarizationcited by 402
  21. 2022Self-critiquing models for assisting human evaluatorscited by 372
  22. 2023GPTScore: Evaluate as You Desirecited by 357
  23. 2024Benchmarking Retrieval-Augmented Generation for Medicinecited by 326
  24. 2024BioMistral: A Collection of Open-Source Pretrained Large Language Models for Medical Domainscited by 299
  25. 2023Towards Generalist Biomedical AIcited by 286
  26. 2023MEDITRON-70B: Scaling Medical Pretraining for Large Language Modelscited by 272
  27. 2022GatorTron: A Large Clinical Language Model to Unlock Patient Information from Unstructured Electronic Health Recordscited by 238
  28. 2021QAFactEval: Improved QA-Based Factual Consistency Evaluation for Summarizationcited by 233
  29. 2022ASQA: Factoid Questions Meet Long-Form Answerscited by 231
  30. 2024Self-Play Preference Optimization for Language Model Alignmentcited by 228
  31. 2023Fine-tuning Language Models for Factualitycited by 219
  32. 2022Factuality Enhanced Language Models for Open-Ended Text Generationcited by 200
  33. 2023MedCPT: Contrastive Pre-trained Transformers with Large-scale PubMed Search Logs for Zero-shot Biomedical Information Retrievalcited by 182
  34. 2021Hurdles to Progress in Long-form Question Answeringcited by 166
  35. 2023Med-HALT: Medical Domain Hallucination Test for Large Language Modelscited by 156
  36. 2018Lessons from Natural Language Inference in the Clinical Domaincited by 149
  37. 2024Long-form factuality in large language modelscited by 146
  38. 2024Large Legal Fictions: Profiling Legal Hallucinations in Large Language Modelscited by 144

50 most cited of 63 All 63 (JSON)

Built on by

Cited by year (2026 to 7 Oct)

Citing papers per year: 2024: 4; 2025: 11; 2026: 5.

20 papers.

Sort:

By area:

  1. 2024Large language model validity via enhanced conformal prediction methodscited by 91
  2. 2025Mask-DPO: Generalizable Fine-grained Factuality Alignment of LLMscited by 22
  3. 2025Automatic Evaluation of Healthcare LLMs Beyond Question-Answeringcited by 19
  4. 2024LLMs are not Zero-Shot Reasoners for Biomedical Information Extractioncited by 9
  5. 2025Benchmarking Large Language Models on Multiple Tasks in Bioinformatics NLP with Promptingcited by 8
  6. 2025Response Quality Assessment for Retrieval-Augmented Generation via Conditional Conformal Factualitycited by 8
  7. 2025Structured Outputs Enable General-Purpose LLMs to be Medical Expertscited by 6
  8. 2025MedBioLM: Optimizing Medical and Biological QA with Fine-Tuned Large Language Models and Retrieval-Augmented Generationcited by 5
  9. 2026Conformal Policy Controlcited by 5
  10. 2025Understanding the Effects of Domain Finetuning on LLMscited by 4
  11. 2024HALO: Hallucination Analysis and Learning Optimization to Empower LLMs with Retrieval-Augmented Context for Guided Clinical Decision Makingcited by 3
  12. 2025Harnessing RLHF for Robust Unanswerability Recognition and Trustworthy Response Generation in LLMscited by 3
8 more
  1. 2026Two-Level Meta-Rubrics for Evaluating Open-Ended Generation: GAMUT, a Benchmark for Factual Completenesscited by 2
  2. 2025EvidenceMap: Learning Evidence Analysis to Unleash the Power of Small Language Models for Biomedical Question Answeringcited by 1
  3. 2025Large Language Models for Cancer Communication: Evaluating Linguistic Quality, Safety, and Accessibility in Generative AIcited by 1
  4. 2025MedBioRAG: Semantic Search and Retrieval-Augmented Generation with Large Language Models for Medical and Biological QAcited by 1
  5. 2026Multi-LLM Adaptive Conformal Inference for Reliable LLM Responsescited by 1
  6. 2026Breaking Failure Cascades: Step-Aware Reinforcement Learning for Medical Multimodal Reasoningcited by 1
  7. 2024Culinary Class Wars: Evaluating LLMs using ASH in Cuisine Transfer Taskcited by 0
  8. 2026OpenBioRQ: Unsolved Biomedical Research Questions for Agentscited by 0