Automating psychological hypothesis generation with AI: when large language models meet causal graph
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Abstract (arXiv)
Leveraging the synergy between causal knowledge graphs and a large language model (LLM), our study introduces a groundbreaking approach for computational hypothesis generation in psychology. We analyzed 43,312 psychology articles using a LLM to extract causal relation pairs. This analysis produced a specialized causal graph for psychology. Applying link prediction algorithms, we generated 130 potential psychological hypotheses focusing on `well-being', then compared them against research ideas conceived by doctoral scholars and those produced solely by the LLM. Interestingly, our combined approach of a LLM and causal graphs mirrored the expert-level insights in terms of novelty, clearly surpassing the LLM-only hypotheses (t(59) = 3.34, p=0.007 and t(59) = 4.32, p<0.001, respectively). This alignment was further corroborated using deep semantic analysis. Our results show that combining LLM with machine learning techniques such as causal knowledge graphs can revolutionize automated discovery in psychology, extracting novel insights from the extensive literature. This work stands at the crossroads of psychology and artificial intelligence, championing a new enriched paradigm for data-driven hypothesis generation in psychological research.
Key facts. Cited by 15 papers in the map (data through 7 Oct 2026). Builds on 9 of its 60 references that are in the map. First posted on arXiv 22 Feb 2024.
Builds on
9 of 60 references.
References · 9
- 2017Attention Is All You Needcited by 59,932
- 2018BERT: Pre-training of Deep Bidirectional Transformers for Language Understandingcited by 40,204
- 2023Unifying Large Language Models and Knowledge Graphs: A Roadmapcited by 663
- 2022Using cognitive psychology to understand GPT-3cited by 389
- 2023ConceptGraphs: Open-Vocabulary 3D Scene Graphs for Perception and Planningcited by 357
- 2023Causal Reasoning and Large Language Models: Opening a New Frontier for Causalitycited by 348
- 2023A Comparative Study of Open-Source Large Language Models, GPT-4 and Claude 2: Multiple-Choice Test Taking in Nephrologycited by 26
- 2019Predicting Research Trends with Semantic and Neural Networks with an application in Quantum Physicscited by 24
- 2023Academic Writing with GPT-3.5: Reflections on Practices, Efficacy and Transparencycited by 6
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Citing papers per year: 2024: 1; 2025: 10; 2026: 4.
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- 2025Autonomous Agents for Scientific Discovery: Orchestrating Scientists, Language, Code, and Physicscited by 11
- 202534 Examples of LLM Applications in Materials Science and Chemistry: Towards Automation, Assistants, Agents, and Accelerated Scientific Discoverycited by 9
- 2025A Survey on Enhancing Causal Reasoning Ability of Large Language Modelscited by 8
- 2025LLM Cannot Discover Causality, and Should Be Restricted to Non-Decisional Support in Causal Discoverycited by 7
- 2025Deep Associations, High Creativity: A Simple yet Effective Metric for Evaluating Large Language Modelscited by 6
- 2025Deconstructing Depression Stigma: Integrating AI-driven Data Collection and Analysis with Causal Knowledge Graphscited by 4
- 2025"The Diagram is like Guardrails": Structuring GenAI-assisted Hypotheses Exploration with an Interactive Shared Representationcited by 3
- 2024Simulating Tabular Datasets through LLMs to Rapidly Explore Hypotheses about Real-World Entitiescited by 2
- 2025EvidenceBench: A Benchmark for Extracting Evidence from Biomedical Paperscited by 2
- 2026COGTRL: Training LLMs for Scientific Discovery Assistance using Cognitive Traces via Reinforcement Learningcited by 1
- 2025InterFeat: A Pipeline for Finding Interesting Scientific Featurescited by 0
- 2025Student Development Agent: Risk-free Simulation for Evaluating AIED Innovationscited by 0
3 more
- 2026Designing Computational Tools for Exploring Causal Relationships in Qualitative Datacited by 0
- 2026A phenotype-driven and evidence-governed framework for knowledge graph enrichment and hypotheses discovery in population datacited by 0
- 2026HypoKG: Evidence-Disciplined Biomedical Hypothesis Generation Beyond Endpoint Knowledgecited by 0
- 2026HypoKG: Evidence-Disciplined Biomedical Hypothesis Generation Beyond Endpoint Knowledge10 Sep 2026
- 2026COGTRL: Training LLMs for Scientific Discovery Assistance using Cognitive Traces via Reinforcement Learning31 Aug 2026
- 2026A phenotype-driven and evidence-governed framework for knowledge graph enrichment and hypotheses discovery in population data18 Apr 2026
- 2026Designing Computational Tools for Exploring Causal Relationships in Qualitative Data6 Feb 2026
- 2025Deep Associations, High Creativity: A Simple yet Effective Metric for Evaluating Large Language Models14 Oct 2025
- 2025Autonomous Agents for Scientific Discovery: Orchestrating Scientists, Language, Code, and Physics10 Oct 2025
- 2025Student Development Agent: Risk-free Simulation for Evaluating AIED Innovations10 Oct 2025
- 2025LLM Cannot Discover Causality, and Should Be Restricted to Non-Decisional Support in Causal Discovery1 Jun 2025
- 2025InterFeat: A Pipeline for Finding Interesting Scientific Features18 May 2025
- 202534 Examples of LLM Applications in Materials Science and Chemistry: Towards Automation, Assistants, Agents, and Accelerated Scientific Discovery5 May 2025
- 2025EvidenceBench: A Benchmark for Extracting Evidence from Biomedical Papers25 Apr 2025
- 2025"The Diagram is like Guardrails": Structuring GenAI-assisted Hypotheses Exploration with an Interactive Shared Representation21 Mar 2025
3 more
- 2025A Survey on Enhancing Causal Reasoning Ability of Large Language Models12 Mar 2025
- 2025Deconstructing Depression Stigma: Integrating AI-driven Data Collection and Analysis with Causal Knowledge Graphs9 Feb 2025
- 2024Simulating Tabular Datasets through LLMs to Rapidly Explore Hypotheses about Real-World Entities27 Nov 2024
- 202534 Examples of LLM Applications in Materials Science and Chemistry: Towards Automation, Assistants, Agents, and Accelerated Scientific Discoverycited by 9
- 2025LLM Cannot Discover Causality, and Should Be Restricted to Non-Decisional Support in Causal Discoverycited by 7
- 2025Deep Associations, High Creativity: A Simple yet Effective Metric for Evaluating Large Language Modelscited by 6
- 2025Deconstructing Depression Stigma: Integrating AI-driven Data Collection and Analysis with Causal Knowledge Graphscited by 4
- 2025"The Diagram is like Guardrails": Structuring GenAI-assisted Hypotheses Exploration with an Interactive Shared Representationcited by 3
- 2024Simulating Tabular Datasets through LLMs to Rapidly Explore Hypotheses about Real-World Entitiescited by 2
- 2025EvidenceBench: A Benchmark for Extracting Evidence from Biomedical Paperscited by 2
- 2026COGTRL: Training LLMs for Scientific Discovery Assistance using Cognitive Traces via Reinforcement Learningcited by 1
- 2025InterFeat: A Pipeline for Finding Interesting Scientific Featurescited by 0
- 2026Designing Computational Tools for Exploring Causal Relationships in Qualitative Datacited by 0
- 2026A phenotype-driven and evidence-governed framework for knowledge graph enrichment and hypotheses discovery in population datacited by 0
- 2026HypoKG: Evidence-Disciplined Biomedical Hypothesis Generation Beyond Endpoint Knowledgecited by 0
- 2026HypoKG: Evidence-Disciplined Biomedical Hypothesis Generation Beyond Endpoint Knowledge10 Sep 2026
- 2026COGTRL: Training LLMs for Scientific Discovery Assistance using Cognitive Traces via Reinforcement Learning31 Aug 2026
- 2026A phenotype-driven and evidence-governed framework for knowledge graph enrichment and hypotheses discovery in population data18 Apr 2026
- 2026Designing Computational Tools for Exploring Causal Relationships in Qualitative Data6 Feb 2026
- 2025Deep Associations, High Creativity: A Simple yet Effective Metric for Evaluating Large Language Models14 Oct 2025
- 2025LLM Cannot Discover Causality, and Should Be Restricted to Non-Decisional Support in Causal Discovery1 Jun 2025
- 2025InterFeat: A Pipeline for Finding Interesting Scientific Features18 May 2025
- 202534 Examples of LLM Applications in Materials Science and Chemistry: Towards Automation, Assistants, Agents, and Accelerated Scientific Discovery5 May 2025
- 2025EvidenceBench: A Benchmark for Extracting Evidence from Biomedical Papers25 Apr 2025
- 2025"The Diagram is like Guardrails": Structuring GenAI-assisted Hypotheses Exploration with an Interactive Shared Representation21 Mar 2025
- 2025Deconstructing Depression Stigma: Integrating AI-driven Data Collection and Analysis with Causal Knowledge Graphs9 Feb 2025
- 2024Simulating Tabular Datasets through LLMs to Rapidly Explore Hypotheses about Real-World Entities27 Nov 2024