Clinical Risk Prediction Using Language Models: Benefits And Considerations
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Abstract (arXiv)
The utilization of Electronic Health Records (EHRs) for clinical risk prediction is on the rise. However, strict privacy regulations limit access to comprehensive health records, making it challenging to apply standard machine learning algorithms in practical real-world scenarios. Previous research has addressed this data limitation by incorporating medical ontologies and employing transfer learning methods. In this study, we investigate the potential of leveraging language models (LMs) as a means to incorporate supplementary domain knowledge for improving the performance of various EHR-based risk prediction tasks. Unlike applying LMs to unstructured EHR data such as clinical notes, this study focuses on using textual descriptions within structured EHR to make predictions exclusively based on that information. We extensively compare against previous approaches across various data types and sizes. We find that employing LMs to represent structured EHRs, such as diagnostic histories, leads to improved or at least comparable performance in diverse risk prediction tasks. Furthermore, LM-based approaches offer numerous advantages, including few-shot learning, the capability to handle previously unseen medical concepts, and adaptability to various medical vocabularies. Nevertheless, we underscore, through various experiments, the importance of being cautious when employing such models, as concerns regarding the reliability of LMs persist.
Key facts. Cited by 6 papers in the map (data through 14 Oct 2026). Builds on 21 of its 41 references that are in the map. First posted on arXiv 29 Nov 2023.
Builds on
21 of 41 references.
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9 more
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Citing papers per year: 2024: 1; 2025: 1; 2026: 4.
6 papers.
- 2025Large Language Models are Powerful Electronic Health Record Encoderscited by 26
- 2024DeLLiriuM: A large language model for delirium prediction in the ICU using structured EHRcited by 4
- 2026Retrieval-aligned Tabular Foundation Models Enable Robust Clinical Risk Prediction in Electronic Health Records Under Real-world Constraintscited by 4
- 2026AgentRx: A Benchmark Study of LLM Agents for Multimodal Clinical Prediction Taskscited by 3
- 2026PaReGTA: A Temporally Aware LLM-Based Patient Representation Framework for EHR Analyticscited by 1
- 2026A General Multimodal Probing Framework for Data Fusion and Prediction with Frozen Large Language Models: Evidence from Multimodal EHR Datacited by 0
- 2026A General Multimodal Probing Framework for Data Fusion and Prediction with Frozen Large Language Models: Evidence from Multimodal EHR Data27 Jun 2026
- 2026AgentRx: A Benchmark Study of LLM Agents for Multimodal Clinical Prediction Tasks11 May 2026
- 2026Retrieval-aligned Tabular Foundation Models Enable Robust Clinical Risk Prediction in Electronic Health Records Under Real-world Constraints2 Apr 2026
- 2026PaReGTA: A Temporally Aware LLM-Based Patient Representation Framework for EHR Analytics23 Feb 2026
- 2025Large Language Models are Powerful Electronic Health Record Encoders24 Feb 2025
- 2024DeLLiriuM: A large language model for delirium prediction in the ICU using structured EHR22 Oct 2024