Certification of Deep Learning Models for Medical Image Segmentation
On the map: Diffusion models → Medical imaging and segmentation
Abstract (arXiv)
In medical imaging, segmentation models have known a significant improvement in the past decade and are now used daily in clinical practice. However, similar to classification models, segmentation models are affected by adversarial attacks. In a safety-critical field like healthcare, certifying model predictions is of the utmost importance. Randomized smoothing has been introduced lately and provides a framework to certify models and obtain theoretical guarantees. In this paper, we present for the first time a certified segmentation baseline for medical imaging based on randomized smoothing and diffusion models. Our results show that leveraging the power of denoising diffusion probabilistic models helps us overcome the limits of randomized smoothing. We conduct extensive experiments on five public datasets of chest X-rays, skin lesions, and colonoscopies, and empirically show that we are able to maintain high certified Dice scores even for highly perturbed images. Our work represents the first attempt to certify medical image segmentation models, and we aspire for it to set a foundation for future benchmarks in this crucial and largely uncharted area.
Key facts. Cited by 4 papers in the map (data through 7 Oct 2026). Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models. Builds on 31 of its 39 references that are in the map. First posted on arXiv 5 Oct 2023.
Builds on
31 of 39 references.
Closest ancestors · 1
Same direction, newest first
Other references · 30
- 2015Deep Residual Learning for Image Recognitioncited by 51,809
- 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,604
- 2021Diffusion Models Beat GANs on Image Synthesiscited by 8,185
- 2014Explaining and Harnessing Adversarial Examplescited by 7,287
- 2017Towards Deep Learning Models Resistant to Adversarial Attackscited by 6,326
- 2022Generative Adversarial Networkscited by 5,603
- 2013Intriguing properties of neural networkscited by 5,114
- 2014Fully Convolutional Networks for Semantic Segmentationcited by 4,845
- 2017MobileNets: Efficient Convolutional Neural Networks for Mobile Vision Applicationscited by 3,827
- 2016DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFscited by 3,239
- 2016Towards Evaluating the Robustness of Neural Networkscited by 2,976
- 2016Inception-v4, Inception-ResNet and the Impact of Residual Connections on Learningcited by 1,509
18 more
- 2020Reliable evaluation of adversarial robustness with an ensemble of diverse parameter-free attackscited by 1,442
- 2019Certified Adversarial Robustness via Randomized Smoothingcited by 1,324
- 2018Obfuscated Gradients Give a False Sense of Security: Circumventing Defenses to Adversarial Examplescited by 1,259
- 2019Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)cited by 657
- 2017Adversarial Examples for Semantic Segmentation and Object Detectioncited by 275
- 2019ResUNet++: An Advanced Architecture for Medical Image Segmentationcited by 211
- 2020U-Net and its variants for medical image segmentation: theory and applicationscited by 169
- 2020Medical Image Segmentation Using Deep Learning: A Surveycited by 163
- 2022(Certified!!) Adversarial Robustness for Free!cited by 130
- 2021A Dynamical System Perspective for Lipschitz Neural Networkscited by 59
- 2023A Unified Algebraic Perspective on Lipschitz Neural Networkscited by 58
- 2021Scalable Certified Segmentation via Randomized Smoothingcited by 35
- 2022Self-Ensembling Vision Transformer (SEViT) for Robust Medical Image Classificationcited by 16
- 2021Towards Robust General Medical Image Segmentationcited by 14
- 2020Advocating for Multiple Defense Strategies against Adversarial Examplescited by 11
- 2018Vulnerability Analysis of Chest X-Ray Image Classification Against Adversarial Attackscited by 9
- 2020A Hierarchical Feature Constraint to Camouflage Medical Adversarial Attackscited by 8
- 2022Vector Quantisation for Robust Segmentationcited by 8
Built on by
Citing papers per year: 2024: 2; 2025: 1; 2026: 1.
4 papers.
- 2024PromptSmooth: Certifying Robustness of Medical Vision-Language Models via Prompt Learningcited by 16
- 2024RadGazeGen: Radiomics and Gaze-guided Medical Image Generation using Diffusion Modelscited by 4
- 2026LipNeXt: Scaling up Lipschitz-based Certified Robustness to Billion-parameter Modelscited by 2
- 2025Fast and Flexible Robustness Certificates for Semantic Segmentationcited by 1
- 2026LipNeXt: Scaling up Lipschitz-based Certified Robustness to Billion-parameter Models26 Jan 2026
- 2025Fast and Flexible Robustness Certificates for Semantic Segmentation3 Dec 2025
- 2024RadGazeGen: Radiomics and Gaze-guided Medical Image Generation using Diffusion Models1 Oct 2024
- 2024PromptSmooth: Certifying Robustness of Medical Vision-Language Models via Prompt Learning29 Aug 2024
Similar, not cited
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- 2022Medical Diffusion: Denoising Diffusion Probabilistic Models for 3D Medical Image Generation
- 2025Diffusion Based Ambiguous Image Segmentation
- 2024Evaluating Utility of Memory Efficient Medical Image Generation: A Study on Lung Nodule Segmentation
- 2023Ambiguous Medical Image Segmentation using Diffusion Models
- 2023DiffBoost: Enhancing Medical Image Segmentation via Text-Guided Diffusion Model