CMUNeXt: An Efficient Medical Image Segmentation Network based on Large Kernel and Skip Fusion
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Abstract (arXiv)
The U-shaped architecture has emerged as a crucial paradigm in the design of medical image segmentation networks. However, due to the inherent local limitations of convolution, a fully convolutional segmentation network with U-shaped architecture struggles to effectively extract global context information, which is vital for the precise localization of lesions. While hybrid architectures combining CNNs and Transformers can address these issues, their application in real medical scenarios is limited due to the computational resource constraints imposed by the environment and edge devices. In addition, the convolutional inductive bias in lightweight networks adeptly fits the scarce medical data, which is lacking in the Transformer based network. In order to extract global context information while taking advantage of the inductive bias, we propose CMUNeXt, an efficient fully convolutional lightweight medical image segmentation network, which enables fast and accurate auxiliary diagnosis in real scene scenarios. CMUNeXt leverages large kernel and inverted bottleneck design to thoroughly mix distant spatial and location information, efficiently extracting global context information. We also introduce the Skip-Fusion block, designed to enable smooth skip-connections and ensure ample feature fusion. Experimental results on multiple medical image datasets demonstrate that CMUNeXt outperforms existing heavyweight and lightweight medical image segmentation networks in terms of segmentation performance, while offering a faster inference speed, lighter weights, and a reduced computational cost. The code is available at https://github.com/FengheTan9/CMUNeXt.
Key facts. Cited by 31 papers in the map (data through 7 Oct 2026). Builds on 20 of its 24 references that are in the map. First posted on arXiv 2 Aug 2023.
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20 of 24 references.
References · 20
- 2017Attention Is All You Needcited by 59,932
- 2015Deep Residual Learning for Image Recognitioncited by 51,809
- 2020An Image is Worth 16x16 Words: Transformers for Image Recognition at Scalecited by 29,915
- 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,604
- 2021Swin Transformer: Hierarchical Vision Transformer using Shifted Windowscited by 12,082
- 2018MobileNetV2: Inverted Residuals and Linear Bottleneckscited by 4,773
- 2022A ConvNet for the 2020scited by 3,545
- 2021TransUNet: Transformers Make Strong Encoders for Medical Image Segmentationcited by 1,552
- 2021MLP-Mixer: An all-MLP Architecture for Visioncited by 1,441
- 2018Attention U-Net: Learning Where to Look for the Pancreascited by 1,420
- 2021Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentationcited by 1,218
- 2021MobileViT: Light-weight, General-purpose, and Mobile-friendly Vision Transformercited by 636
8 more
- 2019UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentationcited by 583
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- 2021Medical Transformer: Gated Axial-Attention for Medical Image Segmentationcited by 319
- 2022Patches Are All You Need?cited by 201
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Citing papers per year: 2023: 1; 2024: 0; 2025: 14; 2026: 16.
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- 2025MK-UNet: Multi-kernel Lightweight CNN for Medical Image Segmentationcited by 12
- 2025Pre-Trained LLM is a Semantic-Aware and Generalizable Segmentation Boostercited by 7
- 2025Mobile U-ViT: Revisiting large kernel and U-shaped ViT for efficient medical image segmentationcited by 6
- 2025Catheter Detection and Segmentation in X-ray Images via Multi-task Learningcited by 3
- 2025UltraLBM-UNet: Ultralight Bidirectional Mamba-based Model for Skin Lesion Segmentationcited by 3
- 2025U-RWKV: Lightweight medical image segmentation with direction-adaptive RWKVcited by 2
- 2026MIP Candy: A Modular PyTorch Framework for Medical Image Processingcited by 2
- 2025MSA-UNet3+: Multi-Scale Attention UNet3+ with New Supervised Prototypical Contrastive Loss for Coronary DSA Image Segmentationcited by 1
- 2025CARE: Anti-entanglement Ultrasound Image Segmentation via Channel-Aware Region Extricationcited by 1
- 2025LGMSNet: Thinning a medical image segmentation model via dual-level multiscale fusioncited by 1
- 2025LoMix: Learnable Weighted Multi-Scale Logits Mixing for Medical Image Segmentationcited by 1
- 2023Inspecting Model Fairness in Ultrasound Segmentation Taskscited by 0
19 more
- 2025ScaleFusionNet: Transformer-Guided Multi-Scale Feature Fusion for Skin Lesion Segmentationcited by 0
- 2025DyGLNet: Hybrid Global-Local Feature Fusion with Dynamic Upsampling for Medical Image Segmentationcited by 0
- 2025CephRes-MHNet: A Multi-Head Residual Network for Accurate and Robust Cephalometric Landmark Detectioncited by 0
- 2025Layer-wise Noise Guided Selective Wavelet Reconstruction for Robust Medical Image Segmentationcited by 0
- 2026LAW & ORDER: Adaptive Spatial Weighting for Medical Diffusion and Segmentationcited by 0
- 2026Concept-to-Pixel: Prompt-Free Universal Medical Image Segmentationcited by 0
- 2026MonoUNet: A Robust Tiny Neural Network for Automated Knee Cartilage Segmentation on Point-of-Care Ultrasound Devicescited by 0
- 2026PBE-UNet: A light weight Progressive Boundary-Enhanced U-Net with Scale-Aware Aggregation for Ultrasound Image Segmentationcited by 0
- 2026UHR-Net: An Uncertainty-Aware Hypergraph Refinement Network for Medical Image Segmentationcited by 0
- 2026XTinyU-Net: Training-Free U-Net Scaling via Initialization-Time Sensitivitycited by 0
- 2026Polygon-mamba: Retinal vessel segmentation using polygon scanning mamba and space-frequency collaborative attentioncited by 0
- 2026DepthPolyp: Pseudo-Depth Guided Lightweight Segmentation for Real-Time Colonoscopycited by 0
- 2026HTC-SGA Former: A Hybrid Transformer-CNN Network with Self-Guided Attention and a New Boundary-Weighted Adaptive Loss for Coronary DSA Vessel Segmentationcited by 0
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigmscited by 0
- 2026Lightweight Polyp Segmentation via a Gain-Aware Prediction-Space Recursive Controllercited by 0
- 2026MoSSGate: Memory-Modulated State-Space Gating for Skin Lesion Segmentationcited by 0
- 2026GAD-MambaUNet: Direction-Group Mamba with Gradient-Adaptive DINOv3 Distillation for Lightweight Medical Image Segmentationcited by 0
- 2026LightMIS: Ultra-Lightweight Medical Image Segmentation Without a Stage-Wise Decodercited by 0
- 2026Parameter-Efficient 3D Segmentation of Liver and Liver tumors: Depthwise factorization Scales Better Than Dense Convolution with Spatial Dimensionalitycited by 0
- 2026Parameter-Efficient 3D Segmentation of Liver and Liver tumors: Depthwise factorization Scales Better Than Dense Convolution with Spatial Dimensionality27 Sep 2026
- 2026LightMIS: Ultra-Lightweight Medical Image Segmentation Without a Stage-Wise Decoder23 Sep 2026
- 2026GAD-MambaUNet: Direction-Group Mamba with Gradient-Adaptive DINOv3 Distillation for Lightweight Medical Image Segmentation22 Sep 2026
- 2026MoSSGate: Memory-Modulated State-Space Gating for Skin Lesion Segmentation24 Jul 2026
- 2026Lightweight Polyp Segmentation via a Gain-Aware Prediction-Space Recursive Controller3 Jul 2026
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigms29 Jun 2026
- 2026HTC-SGA Former: A Hybrid Transformer-CNN Network with Self-Guided Attention and a New Boundary-Weighted Adaptive Loss for Coronary DSA Vessel Segmentation29 Jun 2026
- 2026DepthPolyp: Pseudo-Depth Guided Lightweight Segmentation for Real-Time Colonoscopy15 May 2026
- 2026Polygon-mamba: Retinal vessel segmentation using polygon scanning mamba and space-frequency collaborative attention11 May 2026
- 2026XTinyU-Net: Training-Free U-Net Scaling via Initialization-Time Sensitivity10 May 2026
- 2026UHR-Net: An Uncertainty-Aware Hypergraph Refinement Network for Medical Image Segmentation30 Apr 2026
- 2026PBE-UNet: A light weight Progressive Boundary-Enhanced U-Net with Scale-Aware Aggregation for Ultrasound Image Segmentation15 Apr 2026
19 more
- 2026MonoUNet: A Robust Tiny Neural Network for Automated Knee Cartilage Segmentation on Point-of-Care Ultrasound Devices9 Apr 2026
- 2026Concept-to-Pixel: Prompt-Free Universal Medical Image Segmentation18 Mar 2026
- 2026LAW & ORDER: Adaptive Spatial Weighting for Medical Diffusion and Segmentation5 Mar 2026
- 2026MIP Candy: A Modular PyTorch Framework for Medical Image Processing24 Feb 2026
- 2025UltraLBM-UNet: Ultralight Bidirectional Mamba-based Model for Skin Lesion Segmentation25 Dec 2025
- 2025Layer-wise Noise Guided Selective Wavelet Reconstruction for Robust Medical Image Segmentation20 Nov 2025
- 2025CephRes-MHNet: A Multi-Head Residual Network for Accurate and Robust Cephalometric Landmark Detection13 Nov 2025
- 2025LoMix: Learnable Weighted Multi-Scale Logits Mixing for Medical Image Segmentation27 Oct 2025
- 2025MK-UNet: Multi-kernel Lightweight CNN for Medical Image Segmentation23 Sep 2025
- 2025DyGLNet: Hybrid Global-Local Feature Fusion with Dynamic Upsampling for Medical Image Segmentation16 Sep 2025
- 2025LGMSNet: Thinning a medical image segmentation model via dual-level multiscale fusion21 Aug 2025
- 2025CARE: Anti-entanglement Ultrasound Image Segmentation via Channel-Aware Region Extrication19 Aug 2025
- 2025Mobile U-ViT: Revisiting large kernel and U-shaped ViT for efficient medical image segmentation1 Aug 2025
- 2025U-RWKV: Lightweight medical image segmentation with direction-adaptive RWKV15 Jul 2025
- 2025Pre-Trained LLM is a Semantic-Aware and Generalizable Segmentation Booster22 Jun 2025
- 2025MSA-UNet3+: Multi-Scale Attention UNet3+ with New Supervised Prototypical Contrastive Loss for Coronary DSA Image Segmentation7 Apr 2025
- 2025ScaleFusionNet: Transformer-Guided Multi-Scale Feature Fusion for Skin Lesion Segmentation5 Mar 2025
- 2025Catheter Detection and Segmentation in X-ray Images via Multi-task Learning4 Mar 2025
- 2023Inspecting Model Fairness in Ultrasound Segmentation Tasks5 Dec 2023
- 2025UltraLBM-UNet: Ultralight Bidirectional Mamba-based Model for Skin Lesion Segmentationcited by 3
- 2026Polygon-mamba: Retinal vessel segmentation using polygon scanning mamba and space-frequency collaborative attentioncited by 0
- 2026GAD-MambaUNet: Direction-Group Mamba with Gradient-Adaptive DINOv3 Distillation for Lightweight Medical Image Segmentationcited by 0
- 2026GAD-MambaUNet: Direction-Group Mamba with Gradient-Adaptive DINOv3 Distillation for Lightweight Medical Image Segmentation22 Sep 2026
- 2026Polygon-mamba: Retinal vessel segmentation using polygon scanning mamba and space-frequency collaborative attention11 May 2026
- 2025UltraLBM-UNet: Ultralight Bidirectional Mamba-based Model for Skin Lesion Segmentation25 Dec 2025
- 2025MK-UNet: Multi-kernel Lightweight CNN for Medical Image Segmentationcited by 12
- 2025Pre-Trained LLM is a Semantic-Aware and Generalizable Segmentation Boostercited by 7
- 2025Mobile U-ViT: Revisiting large kernel and U-shaped ViT for efficient medical image segmentationcited by 6
- 2025Catheter Detection and Segmentation in X-ray Images via Multi-task Learningcited by 3
- 2025U-RWKV: Lightweight medical image segmentation with direction-adaptive RWKVcited by 2
- 2026MIP Candy: A Modular PyTorch Framework for Medical Image Processingcited by 2
- 2025MSA-UNet3+: Multi-Scale Attention UNet3+ with New Supervised Prototypical Contrastive Loss for Coronary DSA Image Segmentationcited by 1
- 2025CARE: Anti-entanglement Ultrasound Image Segmentation via Channel-Aware Region Extricationcited by 1
- 2025LGMSNet: Thinning a medical image segmentation model via dual-level multiscale fusioncited by 1
- 2025LoMix: Learnable Weighted Multi-Scale Logits Mixing for Medical Image Segmentationcited by 1
- 2023Inspecting Model Fairness in Ultrasound Segmentation Taskscited by 0
- 2025ScaleFusionNet: Transformer-Guided Multi-Scale Feature Fusion for Skin Lesion Segmentationcited by 0
12 most cited of 28 All 28 (JSON)
- 2026Parameter-Efficient 3D Segmentation of Liver and Liver tumors: Depthwise factorization Scales Better Than Dense Convolution with Spatial Dimensionality27 Sep 2026
- 2026LightMIS: Ultra-Lightweight Medical Image Segmentation Without a Stage-Wise Decoder23 Sep 2026
- 2026MoSSGate: Memory-Modulated State-Space Gating for Skin Lesion Segmentation24 Jul 2026
- 2026Lightweight Polyp Segmentation via a Gain-Aware Prediction-Space Recursive Controller3 Jul 2026
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigms29 Jun 2026
- 2026HTC-SGA Former: A Hybrid Transformer-CNN Network with Self-Guided Attention and a New Boundary-Weighted Adaptive Loss for Coronary DSA Vessel Segmentation29 Jun 2026
- 2026DepthPolyp: Pseudo-Depth Guided Lightweight Segmentation for Real-Time Colonoscopy15 May 2026
- 2026XTinyU-Net: Training-Free U-Net Scaling via Initialization-Time Sensitivity10 May 2026
- 2026UHR-Net: An Uncertainty-Aware Hypergraph Refinement Network for Medical Image Segmentation30 Apr 2026
- 2026PBE-UNet: A light weight Progressive Boundary-Enhanced U-Net with Scale-Aware Aggregation for Ultrasound Image Segmentation15 Apr 2026
- 2026MonoUNet: A Robust Tiny Neural Network for Automated Knee Cartilage Segmentation on Point-of-Care Ultrasound Devices9 Apr 2026
- 2026Concept-to-Pixel: Prompt-Free Universal Medical Image Segmentation18 Mar 2026
12 newest of 28 All 28 (JSON)