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Generalizing experimental findings: identification beyond adjustments

arXiv 2206.06699 ↗First posted 14 Jun 2022stat.ME cs.LGcited by 0

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Abstract (arXiv)

We aim to generalize the results of a randomized controlled trial (RCT) to a target population with the help of some observational data. This is a problem of causal effect identification with multiple data sources. Challenges arise when the RCT is conducted in a context that differs from the target population. Earlier research has focused on cases where the estimates from the RCT can be adjusted by observational data in order to remove the selection bias and other domain specific differences. We consider examples where the experimental findings cannot be generalized by an adjustment and show that the generalization may still be possible by other identification strategies that can be derived by applying do-calculus. The obtained identifying functionals for these examples contain trapdoor variables of a new type. The value of a trapdoor variable needs to be fixed in the estimation and the choice of the value may have a major effect on the bias and accuracy of estimates, which is also seen in simulations. The presented results expand the scope of settings where the generalization of experimental findings is doable

Key facts. No citing papers in the map yet (data through 14 Oct 2026). Builds on 10 of its 32 references that are in the map. First posted on arXiv 14 Jun 2022.

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10 of 32 references.

References · 10

  1. 2016Identifying Causal Effects With Proxy Variables of an Unmeasured Confoundercited by 139
  2. 2015External Validity: From Do-Calculus to Transportability Across Populationscited by 75
  3. 2020Causal inference methods for combining randomized trials and observational studies: a reviewcited by 51
  4. 2021A Review of Generalizability and Transportabilitycited by 37
  5. 2017Generalizing causal inferences from individuals in randomized trials to all trial-eligible individualscited by 25
  6. 2020Identifying Causal Effects via Context-specific Independence Relationscited by 22
  7. 2018Identifying Causal Effects with the R Package causaleffectcited by 19
  8. 2019Causal Effect Identification from Multiple Incomplete Data Sources: A General Search-based Approachcited by 16
  9. 2020Estimation of causal effects with small data in the presence of trapdoor variablescited by 4
  10. 2020Do-search -- a tool for causal inference and study design with multiple data sourcescited by 1

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