Generalizing causal inferences from individuals in randomized trials to all trial-eligible individuals
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Abstract (arXiv)
We consider methods for causal inference in randomized trials nested within cohorts of trial-eligible individuals, including those who are not randomized. We show how baseline covariate data from the entire cohort, and treatment and outcome data only from randomized individuals, can be used to identify potential (counterfactual) outcome means and average treatment effects in the target population of all eligible individuals. We review identifiability conditions, propose estimators, and assess the estimators' finite-sample performance in simulation studies. As an illustration, we apply the estimators in a trial nested within a cohort of trial-eligible individuals to compare coronary artery bypass grafting surgery plus medical therapy vs. medical therapy alone for chronic coronary artery disease.
Key facts. Cited by 24 papers in the map (data through 7 Oct 2026). First posted on arXiv 14 Sep 2017.
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Citing papers per year: 2021: 4; 2022: 2; 2023: 5; 2024: 7; 2025: 0; 2026: 6.
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- 2021A Review of Generalizability and Transportabilitycited by 36
- 2021Generalizing Off-Policy Learning under Sample Selection Biascited by 16
- 2021A Tree-based Model Averaging Approach for Personalized Treatment Effect Estimation from Heterogeneous Data Sourcescited by 14
- 2024Prediction-powered Generalization of Causal Inferencescited by 14
- 2023Multiply Robust Federated Estimation of Targeted Average Treatment Effectscited by 13
- 2021Intact-VAE: Estimating Treatment Effects under Unobserved Confoundingcited by 10
- 2023Falsification of Internal and External Validity in Observational Studies via Conditional Moment Restrictionscited by 10
- 2023Offline Minimax Soft-Q-learning Under Realizability and Partial Coveragecited by 9
- 2024Adaptive-TMLE for the Average Treatment Effect based on Randomized Controlled Trial Augmented with Real-World Datacited by 7
- 2023Efficient and robust transfer learning of optimal individualized treatment regimes with right-censored survival datacited by 5
- 2024Benchmarking Observational Studies with Experimental Data under Right-Censoringcited by 4
- 2024Towards Generalizing Inferences from Trials to Target Populationscited by 3
12 more
- 2024Beyond Reweighting: On the Predictive Role of Covariate Shift in Effect Generalizationcited by 3
- 2022Targeted Optimal Treatment Regime Learning Using Summary Statisticscited by 2
- 2024Continuous Treatment Effects with Surrogate Outcomescited by 1
- 2022Generalizing experimental findings: identification beyond adjustmentscited by 0
- 2023Constructing Synthetic Treatment Groups without the Mean Exchangeability Assumptioncited by 0
- 2024Testing Generalizability in Causal Inferencecited by 0
- 2026TEA-Time: Transporting Effects Across Timecited by 0
- 2026Transfer Learning for Meta-analysis Under Covariate Shiftcited by 0
- 2026Bayesian fusion forests for heterogeneous treatment effects on survival from randomised and real-world datacited by 0
- 2026Augmented Inverse Hybrid Weighting: Robust Inference under Deterministic and Random Distribution Shiftscited by 0
- 2026Target-Weighted Neyman Allocation: Experimental Design for Heterogeneous Treatment Effects under Population Shiftcited by 0
- 2026Amortized Data Borrowing with Exchangeability-Aware Neural Posterior Estimationcited by 0
- 2026Amortized Data Borrowing with Exchangeability-Aware Neural Posterior Estimation30 Sep 2026
- 2026Target-Weighted Neyman Allocation: Experimental Design for Heterogeneous Treatment Effects under Population Shift6 Aug 2026
- 2026Augmented Inverse Hybrid Weighting: Robust Inference under Deterministic and Random Distribution Shifts1 Aug 2026
- 2026Bayesian fusion forests for heterogeneous treatment effects on survival from randomised and real-world data31 Jul 2026
- 2026Transfer Learning for Meta-analysis Under Covariate Shift3 Apr 2026
- 2026TEA-Time: Transporting Effects Across Time7 Mar 2026
- 2024Beyond Reweighting: On the Predictive Role of Covariate Shift in Effect Generalization12 Dec 2024
- 2024Testing Generalizability in Causal Inference5 Nov 2024
- 2024Prediction-powered Generalization of Causal Inferences5 Jun 2024
- 2024Adaptive-TMLE for the Average Treatment Effect based on Randomized Controlled Trial Augmented with Real-World Data12 May 2024
- 2024Towards Generalizing Inferences from Trials to Target Populations26 Feb 2024
- 2024Benchmarking Observational Studies with Experimental Data under Right-Censoring23 Feb 2024
12 more
- 2024Continuous Treatment Effects with Surrogate Outcomes31 Jan 2024
- 2023Constructing Synthetic Treatment Groups without the Mean Exchangeability Assumption28 Sep 2023
- 2023Multiply Robust Federated Estimation of Targeted Average Treatment Effects22 Sep 2023
- 2023Offline Minimax Soft-Q-learning Under Realizability and Partial Coverage5 Feb 2023
- 2023Falsification of Internal and External Validity in Observational Studies via Conditional Moment Restrictions30 Jan 2023
- 2023Efficient and robust transfer learning of optimal individualized treatment regimes with right-censored survival data13 Jan 2023
- 2022Generalizing experimental findings: identification beyond adjustments14 Jun 2022
- 2022Targeted Optimal Treatment Regime Learning Using Summary Statistics17 Jan 2022
- 2021Generalizing Off-Policy Learning under Sample Selection Bias2 Dec 2021
- 2021A Tree-based Model Averaging Approach for Personalized Treatment Effect Estimation from Heterogeneous Data Sources10 Mar 2021
- 2021A Review of Generalizability and Transportability23 Feb 2021
- 2021Intact-VAE: Estimating Treatment Effects under Unobserved Confounding17 Jan 2021
- 2021A Review of Generalizability and Transportabilitycited by 36
- 2021Generalizing Off-Policy Learning under Sample Selection Biascited by 16
- 2021A Tree-based Model Averaging Approach for Personalized Treatment Effect Estimation from Heterogeneous Data Sourcescited by 14
- 2024Prediction-powered Generalization of Causal Inferencescited by 14
- 2023Multiply Robust Federated Estimation of Targeted Average Treatment Effectscited by 13
- 2021Intact-VAE: Estimating Treatment Effects under Unobserved Confoundingcited by 10
- 2023Falsification of Internal and External Validity in Observational Studies via Conditional Moment Restrictionscited by 10
- 2024Adaptive-TMLE for the Average Treatment Effect based on Randomized Controlled Trial Augmented with Real-World Datacited by 7
- 2023Efficient and robust transfer learning of optimal individualized treatment regimes with right-censored survival datacited by 5
- 2024Benchmarking Observational Studies with Experimental Data under Right-Censoringcited by 4
- 2024Towards Generalizing Inferences from Trials to Target Populationscited by 3
- 2024Beyond Reweighting: On the Predictive Role of Covariate Shift in Effect Generalizationcited by 3
12 most cited of 23 All 23 (JSON)
- 2026Amortized Data Borrowing with Exchangeability-Aware Neural Posterior Estimation30 Sep 2026
- 2026Target-Weighted Neyman Allocation: Experimental Design for Heterogeneous Treatment Effects under Population Shift6 Aug 2026
- 2026Augmented Inverse Hybrid Weighting: Robust Inference under Deterministic and Random Distribution Shifts1 Aug 2026
- 2026Bayesian fusion forests for heterogeneous treatment effects on survival from randomised and real-world data31 Jul 2026
- 2026Transfer Learning for Meta-analysis Under Covariate Shift3 Apr 2026
- 2026TEA-Time: Transporting Effects Across Time7 Mar 2026
- 2024Beyond Reweighting: On the Predictive Role of Covariate Shift in Effect Generalization12 Dec 2024
- 2024Testing Generalizability in Causal Inference5 Nov 2024
- 2024Prediction-powered Generalization of Causal Inferences5 Jun 2024
- 2024Adaptive-TMLE for the Average Treatment Effect based on Randomized Controlled Trial Augmented with Real-World Data12 May 2024
- 2024Towards Generalizing Inferences from Trials to Target Populations26 Feb 2024
- 2024Benchmarking Observational Studies with Experimental Data under Right-Censoring23 Feb 2024
12 newest of 23 All 23 (JSON)