Decorate the Examples: A Simple Method of Prompt Design for Biomedical Relation Extraction
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Abstract (arXiv)
Relation extraction is a core problem for natural language processing in the biomedical domain. Recent research on relation extraction showed that prompt-based learning improves the performance on both fine-tuning on full training set and few-shot training. However, less effort has been made on domain-specific tasks where good prompt design can be even harder. In this paper, we investigate prompting for biomedical relation extraction, with experiments on the ChemProt dataset. We present a simple yet effective method to systematically generate comprehensive prompts that reformulate the relation extraction task as a cloze-test task under a simple prompt formulation. In particular, we experiment with different ranking scores for prompt selection. With BioMed-RoBERTa-base, our results show that prompting-based fine-tuning obtains gains by 14.21 F1 over its regular fine-tuning baseline, and 1.14 F1 over SciFive-Large, the current state-of-the-art on ChemProt. Besides, we find prompt-based learning requires fewer training examples to make reasonable predictions. The results demonstrate the potential of our methods in such a domain-specific relation extraction task.
Key facts. Cited by 5 papers in the map (data through 7 Oct 2026). Builds on 31 of its 40 references that are in the map. First posted on arXiv 21 Apr 2022.
Builds on
31 of 40 references.
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19 more
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Citing papers per year: 2022: 1; 2023: 0; 2024: 2; 2025: 2.
5 papers.
- 2022Can NLI Provide Proper Indirect Supervision for Low-resource Biomedical Relation Extraction?cited by 13
- 2024Prompt engineering paradigms for medical applications: scoping review and recommendations for better practicescited by 13
- 2024LangGPT: Rethinking Structured Reusable Prompt Design Framework for LLMs from the Programming Languagecited by 12
- 2025Retrieval augmented generation based dynamic prompting for few-shot biomedical named entity recognition using large language modelscited by 1
- 2025Error-Aware Curriculum Learning for Biomedical Relation Classificationcited by 0
- 2025Retrieval augmented generation based dynamic prompting for few-shot biomedical named entity recognition using large language models25 Jul 2025
- 2025Error-Aware Curriculum Learning for Biomedical Relation Classification18 Jul 2025
- 2024Prompt engineering paradigms for medical applications: scoping review and recommendations for better practices2 May 2024
- 2024LangGPT: Rethinking Structured Reusable Prompt Design Framework for LLMs from the Programming Language26 Feb 2024
- 2022Can NLI Provide Proper Indirect Supervision for Low-resource Biomedical Relation Extraction?21 Dec 2022