LifeLonger: A Benchmark for Continual Disease Classification
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Abstract (arXiv)
Deep learning models have shown a great effectiveness in recognition of findings in medical images. However, they cannot handle the ever-changing clinical environment, bringing newly annotated medical data from different sources. To exploit the incoming streams of data, these models would benefit largely from sequentially learning from new samples, without forgetting the previously obtained knowledge. In this paper we introduce LifeLonger, a benchmark for continual disease classification on the MedMNIST collection, by applying existing state-of-the-art continual learning methods. In particular, we consider three continual learning scenarios, namely, task and class incremental learning and the newly defined cross-domain incremental learning. Task and class incremental learning of diseases address the issue of classifying new samples without re-training the models from scratch, while cross-domain incremental learning addresses the issue of dealing with datasets originating from different institutions while retaining the previously obtained knowledge. We perform a thorough analysis of the performance and examine how the well-known challenges of continual learning, such as the catastrophic forgetting exhibit themselves in this setting. The encouraging results demonstrate that continual learning has a major potential to advance disease classification and to produce a more robust and efficient learning framework for clinical settings. The code repository, data partitions and baseline results for the complete benchmark will be made publicly available.
Key facts. Cited by 28 papers in the map (data through 14 Oct 2026). Builds on 26 of its 41 references that are in the map. First posted on arXiv 12 Apr 2022.
Builds on
26 of 41 references.
References · 26
- 2015Deep Residual Learning for Image Recognitioncited by 52,096
- 2016Overcoming catastrophic forgetting in neural networkscited by 4,787
- 2016Learning without Forgettingcited by 2,496
- 2016iCaRL: Incremental Classifier and Representation Learningcited by 2,333
- 2017Gradient Episodic Memory for Continual Learningcited by 1,898
- 2016Progressive Neural Networkscited by 1,361
- 2017A Survey on Deep Learning in Medical Image Analysiscited by 1,186
- 2017Continual Learning with Deep Generative Replaycited by 1,158
- 2017Memory Aware Synapses: Learning what (not) to forgetcited by 1,105
- 2018Riemannian Walk for Incremental Learning: Understanding Forgetting and Intransigencecited by 742
- 2019Large Scale Incremental Learningcited by 732
- 2013An Empirical Investigation of Catastrophic Forgetting in Gradient-Based Neural Networkscited by 722
14 more
- 2019Three scenarios for continual learningcited by 614
- 2018End-to-End Incremental Learningcited by 597
- 2019The Liver Tumor Segmentation Benchmark (LiTS)cited by 509
- 2020Class-incremental learning: survey and performance evaluation on image classificationcited by 449
- 2017Variational Continual Learningcited by 339
- 2020MedMNIST Classification Decathlon: A Lightweight AutoML Benchmark for Medical Image Analysiscited by 206
- 2019Learning to Remember: A Synaptic Plasticity Driven Framework for Continual Learningcited by 182
- 2017FearNet: Brain-Inspired Model for Incremental Learningcited by 177
- 2021Avalanche: an End-to-End Library for Continual Learningcited by 124
- 2020Continual Learning for Domain Adaptation in Chest X-ray Classificationcited by 31
- 2021Kernel Continual Learningcited by 27
- 2020What is Wrong with Continual Learning in Medical Image Segmentation?cited by 25
- 2018Towards continual learning in medical imagingcited by 24
- 2021Adversarial Continual Learning for Multi-Domain Hippocampal Segmentationcited by 14
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Citing papers per year: 2023: 8; 2024: 11; 2025: 7; 2026: 2.
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- 2023ConSlide: Asynchronous Hierarchical Interaction Transformer with Breakup-Reorganize Rehearsal for Continual Whole Slide Image Analysiscited by 25
- 2023Continual Learning in Medical Image Analysis: A Comprehensive Review of Recent Advancements and Future Prospectscited by 22
- 2023Does Continual Learning Equally Forget All Parameters?cited by 18
- 2023Revisiting Distillation for Continual Learning on Visual Question Localized-Answering in Robotic Surgerycited by 15
- 2023A Continual Learning Approach for Cross-Domain White Blood Cell Classificationcited by 10
- 2024Queryable Prototype Multiple Instance Learning with Vision-Language Models for Incremental Whole Slide Image Classificationcited by 10
- 2024Continual Learning in Medical Imaging: A Survey and Practical Analysiscited by 9
- 2023L3DMC: Lifelong Learning using Distillation via Mixed-Curvature Spacecited by 6
- 2023Data efficient deep learning for medical image analysis: A surveycited by 6
- 2024Image Distillation for Safe Data Sharing in Histopathologycited by 6
- 2024FedMedICL: Towards Holistic Evaluation of Distribution Shifts in Federated Medical Imagingcited by 5
- 2024Continual Domain Incremental Learning for Privacy-aware Digital Pathologycited by 5
16 more
- 2023Few-shot Class-incremental Learning for Cross-domain Disease Classificationcited by 4
- 2024Characterizing Continual Learning Scenarios and Strategies for Audio Analysiscited by 3
- 2024Fairness Evolution in Continual Learning for Medical Imagingcited by 2
- 2024CCSI: Continual Class-Specific Impression for Data-free Class Incremental Learningcited by 2
- 2024NCAdapt: Dynamic adaptation with domain-specific Neural Cellular Automata for continual hippocampus segmentationcited by 2
- 2025Attention-based Generative Latent Replay: A Continual Learning Approach for WSI Analysiscited by 2
- 2025DSS-Prompt: Dynamic-Static Synergistic Prompting for Few-Shot Class-Incremental Learningcited by 2
- 2024From Uncertainty to Clarity: Uncertainty-Guided Class-Incremental Learning for Limited Biomedical Samples via Semantic Expansioncited by 1
- 2024Confidence-Based Task Prediction in Continual Disease Classification Using Probability Distributioncited by 0
- 2025Pathological Prior-Guided Multiple Instance Learning For Mitigating Catastrophic Forgetting in Breast Cancer Whole Slide Image Classificationcited by 0
- 2025Dual-Alignment Knowledge Retention for Continual Medical Image Segmentationcited by 0
- 2025Continual Multiple Instance Learning for Hematologic Disease Diagnosiscited by 0
- 2025Improving Learning of New Diseases through Knowledge-Enhanced Initialization for Federated Adapter Tuningcited by 0
- 2025Adversarial Versus Federated: An Adversarial Learning based Multi-Modality Cross-Domain Federated Medical Segmentationcited by 0
- 2026On-Device Continual Learning with Dual-Stage Buffer and Dynamic Loss for Point-of-Care Pneumonia Diagnosiscited by 0
- 2026Learning When to Recur: Token-Adaptive Recursion for Imbalanced Ophthalmic Domain Incremental Learningcited by 0
- 2026Learning When to Recur: Token-Adaptive Recursion for Imbalanced Ophthalmic Domain Incremental Learning26 Sep 2026
- 2026On-Device Continual Learning with Dual-Stage Buffer and Dynamic Loss for Point-of-Care Pneumonia Diagnosis19 May 2026
- 2025Adversarial Versus Federated: An Adversarial Learning based Multi-Modality Cross-Domain Federated Medical Segmentation28 Sep 2025
- 2025Improving Learning of New Diseases through Knowledge-Enhanced Initialization for Federated Adapter Tuning14 Aug 2025
- 2025DSS-Prompt: Dynamic-Static Synergistic Prompting for Few-Shot Class-Incremental Learning13 Aug 2025
- 2025Continual Multiple Instance Learning for Hematologic Disease Diagnosis6 Aug 2025
- 2025Dual-Alignment Knowledge Retention for Continual Medical Image Segmentation4 Jul 2025
- 2025Attention-based Generative Latent Replay: A Continual Learning Approach for WSI Analysis13 May 2025
- 2025Pathological Prior-Guided Multiple Instance Learning For Mitigating Catastrophic Forgetting in Breast Cancer Whole Slide Image Classification8 Mar 2025
- 2024NCAdapt: Dynamic adaptation with domain-specific Neural Cellular Automata for continual hippocampus segmentation30 Oct 2024
- 2024Queryable Prototype Multiple Instance Learning with Vision-Language Models for Incremental Whole Slide Image Classification14 Oct 2024
- 2024From Uncertainty to Clarity: Uncertainty-Guided Class-Incremental Learning for Limited Biomedical Samples via Semantic Expansion12 Sep 2024
16 more
- 2024Continual Domain Incremental Learning for Privacy-aware Digital Pathology10 Sep 2024
- 2024FedMedICL: Towards Holistic Evaluation of Distribution Shifts in Federated Medical Imaging11 Jul 2024
- 2024Characterizing Continual Learning Scenarios and Strategies for Audio Analysis29 Jun 2024
- 2024Image Distillation for Safe Data Sharing in Histopathology19 Jun 2024
- 2024CCSI: Continual Class-Specific Impression for Data-free Class Incremental Learning9 Jun 2024
- 2024Confidence-Based Task Prediction in Continual Disease Classification Using Probability Distribution3 Jun 2024
- 2024Continual Learning in Medical Imaging: A Survey and Practical Analysis22 May 2024
- 2024Fairness Evolution in Continual Learning for Medical Imaging10 Apr 2024
- 2023Continual Learning in Medical Image Analysis: A Comprehensive Review of Recent Advancements and Future Prospects28 Dec 2023
- 2023Data efficient deep learning for medical image analysis: A survey10 Oct 2023
- 2023ConSlide: Asynchronous Hierarchical Interaction Transformer with Breakup-Reorganize Rehearsal for Continual Whole Slide Image Analysis25 Aug 2023
- 2023A Continual Learning Approach for Cross-Domain White Blood Cell Classification24 Aug 2023
- 2023L3DMC: Lifelong Learning using Distillation via Mixed-Curvature Space31 Jul 2023
- 2023Revisiting Distillation for Continual Learning on Visual Question Localized-Answering in Robotic Surgery22 Jul 2023
- 2023Few-shot Class-incremental Learning for Cross-domain Disease Classification12 Apr 2023
- 2023Does Continual Learning Equally Forget All Parameters?9 Apr 2023
- 2023ConSlide: Asynchronous Hierarchical Interaction Transformer with Breakup-Reorganize Rehearsal for Continual Whole Slide Image Analysiscited by 25
- 2023Continual Learning in Medical Image Analysis: A Comprehensive Review of Recent Advancements and Future Prospectscited by 22
- 2023Does Continual Learning Equally Forget All Parameters?cited by 18
- 2023Revisiting Distillation for Continual Learning on Visual Question Localized-Answering in Robotic Surgerycited by 15
- 2023A Continual Learning Approach for Cross-Domain White Blood Cell Classificationcited by 10
- 2024Continual Learning in Medical Imaging: A Survey and Practical Analysiscited by 9
- 2023L3DMC: Lifelong Learning using Distillation via Mixed-Curvature Spacecited by 6
- 2023Data efficient deep learning for medical image analysis: A surveycited by 6
- 2024Image Distillation for Safe Data Sharing in Histopathologycited by 6
- 2024FedMedICL: Towards Holistic Evaluation of Distribution Shifts in Federated Medical Imagingcited by 5
- 2024Continual Domain Incremental Learning for Privacy-aware Digital Pathologycited by 5
- 2023Few-shot Class-incremental Learning for Cross-domain Disease Classificationcited by 4
12 most cited of 27 All 27 (JSON)
- 2026Learning When to Recur: Token-Adaptive Recursion for Imbalanced Ophthalmic Domain Incremental Learning26 Sep 2026
- 2026On-Device Continual Learning with Dual-Stage Buffer and Dynamic Loss for Point-of-Care Pneumonia Diagnosis19 May 2026
- 2025Adversarial Versus Federated: An Adversarial Learning based Multi-Modality Cross-Domain Federated Medical Segmentation28 Sep 2025
- 2025Improving Learning of New Diseases through Knowledge-Enhanced Initialization for Federated Adapter Tuning14 Aug 2025
- 2025DSS-Prompt: Dynamic-Static Synergistic Prompting for Few-Shot Class-Incremental Learning13 Aug 2025
- 2025Continual Multiple Instance Learning for Hematologic Disease Diagnosis6 Aug 2025
- 2025Dual-Alignment Knowledge Retention for Continual Medical Image Segmentation4 Jul 2025
- 2025Attention-based Generative Latent Replay: A Continual Learning Approach for WSI Analysis13 May 2025
- 2025Pathological Prior-Guided Multiple Instance Learning For Mitigating Catastrophic Forgetting in Breast Cancer Whole Slide Image Classification8 Mar 2025
- 2024NCAdapt: Dynamic adaptation with domain-specific Neural Cellular Automata for continual hippocampus segmentation30 Oct 2024
- 2024From Uncertainty to Clarity: Uncertainty-Guided Class-Incremental Learning for Limited Biomedical Samples via Semantic Expansion12 Sep 2024
- 2024Continual Domain Incremental Learning for Privacy-aware Digital Pathology10 Sep 2024
12 newest of 27 All 27 (JSON)