Domain-Specific Pretraining for Vertical Search: Case Study on Biomedical Literature
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Abstract (arXiv)
Information overload is a prevalent challenge in many high-value domains. A prominent case in point is the explosion of the biomedical literature on COVID-19, which swelled to hundreds of thousands of papers in a matter of months. In general, biomedical literature expands by two papers every minute, totalling over a million new papers every year. Search in the biomedical realm, and many other vertical domains is challenging due to the scarcity of direct supervision from click logs. Self-supervised learning has emerged as a promising direction to overcome the annotation bottleneck. We propose a general approach for vertical search based on domain-specific pretraining and present a case study for the biomedical domain. Despite being substantially simpler and not using any relevance labels for training or development, our method performs comparably or better than the best systems in the official TREC-COVID evaluation, a COVID-related biomedical search competition. Using distributed computing in modern cloud infrastructure, our system can scale to tens of millions of articles on PubMed and has been deployed as Microsoft Biomedical Search, a new search experience for biomedical literature: https://aka.ms/biomedsearch.
Key facts. Cited by 6 papers in the map (data through 7 Oct 2026). Builds on 31 of its 48 references that are in the map. First posted on arXiv 25 Jun 2021.
Builds on
31 of 48 references.
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19 more
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Built on by
Citing papers per year: 2021: 1; 2022: 3; 2023: 1; 2024: 0; 2025: 1.
6 papers.
- 2022A Computational Inflection for Scientific Discoverycited by 22
- 2021Literature-Augmented Clinical Outcome Predictioncited by 20
- 2022COCO-DR: Combating Distribution Shifts in Zero-Shot Dense Retrieval with Contrastive and Distributionally Robust Learningcited by 19
- 2022NeuralSearchX: Serving a Multi-billion-parameter Reranker for Multilingual Metasearch at a Low Costcited by 1
- 2023Clinical Notes Reveal Physician Fatiguecited by 1
- 2025A Practical Framework for Evaluating Medical AI Security: Reproducible Assessment of Jailbreaking and Privacy Vulnerabilities Across Clinical Specialtiescited by 0
- 2025A Practical Framework for Evaluating Medical AI Security: Reproducible Assessment of Jailbreaking and Privacy Vulnerabilities Across Clinical Specialties9 Dec 2025
- 2023Clinical Notes Reveal Physician Fatigue5 Dec 2023
- 2022COCO-DR: Combating Distribution Shifts in Zero-Shot Dense Retrieval with Contrastive and Distributionally Robust Learning27 Oct 2022
- 2022NeuralSearchX: Serving a Multi-billion-parameter Reranker for Multilingual Metasearch at a Low Cost26 Oct 2022
- 2022A Computational Inflection for Scientific Discovery4 May 2022
- 2021Literature-Augmented Clinical Outcome Prediction16 Nov 2021