Automated Lay Language Summarization of Biomedical Scientific Reviews
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Abstract (arXiv)
Health literacy has emerged as a crucial factor in making appropriate health decisions and ensuring treatment outcomes. However, medical jargon and the complex structure of professional language in this domain make health information especially hard to interpret. Thus, there is an urgent unmet need for automated methods to enhance the accessibility of the biomedical literature to the general population. This problem can be framed as a type of translation problem between the language of healthcare professionals, and that of the general public. In this paper, we introduce the novel task of automated generation of lay language summaries of biomedical scientific reviews, and construct a dataset to support the development and evaluation of automated methods through which to enhance the accessibility of the biomedical literature. We conduct analyses of the various challenges in solving this task, including not only summarization of the key points but also explanation of background knowledge and simplification of professional language. We experiment with state-of-the-art summarization models as well as several data augmentation techniques, and evaluate their performance using both automated metrics and human assessment. Results indicate that automatically generated summaries produced using contemporary neural architectures can achieve promising quality and readability as compared with reference summaries developed for the lay public by experts (best ROUGE-L of 50.24 and Flesch-Kincaid readability score of 13.30). We also discuss the limitations of the current attempt, providing insights and directions for future work.
Key facts. Cited by 46 papers in the map (data through 13 Oct 2026). First posted on arXiv 23 Dec 2020.
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Citing papers per year: 2021: 1; 2022: 5; 2023: 14; 2024: 8; 2025: 13; 2026: 5.
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- 2023How Far Can Camels Go? Exploring the State of Instruction Tuning on Open Resourcescited by 407
- 2023A Survey of Large Language Models for Healthcare: from Data, Technology, and Applications to Accountability and Ethicscited by 163
- 2023LongEval: Guidelines for Human Evaluation of Faithfulness in Long-form Summarizationcited by 96
- 2023Pearl: Personalizing Large Language Model Writing Assistants with Generation-Calibrated Retrieverscited by 92
- 2021Pre-trained Language Models in Biomedical Domain: A Systematic Surveycited by 87
- 2022Making Science Simple: Corpora for the Lay Summarisation of Scientific Literaturecited by 54
- 2023Generating Summaries with Controllable Readability Levelscited by 24
- 2022Paper Plain: Making Medical Research Papers Approachable to Healthcare Consumers with Natural Language Processingcited by 23
- 2022Retrieval augmentation of large language models for lay language generationcited by 21
- 2022Readability Controllable Biomedical Document Summarizationcited by 19
- 2023README: Bridging Medical Jargon and Lay Understanding for Patient Education through Data-Centric NLPcited by 17
- 2025Multimodal Large Language Models for Medicine: A Comprehensive Surveycited by 16
34 more
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- 2023Personalized Jargon Identification for Enhanced Interdisciplinary Communicationcited by 11
- 2024ReadCtrl: Personalizing text generation with readability-controlled instruction learningcited by 10
- 2023Investigating Large Language Models and Control Mechanisms to Improve Text Readability of Biomedical Abstractscited by 8
- 2023Enhancing Biomedical Lay Summarisation with External Knowledge Graphscited by 8
- 2023Overview of the BioLaySumm 2023 Shared Task on Lay Summarization of Biomedical Research Articlescited by 6
- 2025Evaluating the Evaluators: Are readability metrics good measures of readability?cited by 6
- 2025MedReadCtrl: Personalizing medical text generation with readability-controlled instruction learningcited by 5
- 2026Improving Clinical Diagnosis with Counterfactual Multi-Agent Reasoningcited by 5
- 2024BioMistral-NLU: Towards More Generalizable Medical Language Understanding through Instruction Tuningcited by 4
- 2025Explainable AI for Clinical Outcome Prediction: A Survey of Clinician Perceptions and Preferencescited by 4
- 2025PlainQAFact: Retrieval-augmented Factual Consistency Evaluation Metric for Biomedical Plain Language Summarizationcited by 4
- 2025Explanatory Summarization with Discourse-Driven Planningcited by 4
- 2023A Survey for Biomedical Text Summarization: From Pre-trained to Large Language Modelscited by 3
- 2024Evaluation of Large Language Models for Summarization Tasks in the Medical Domain: A Narrative Reviewcited by 3
- 2025Sci-LoRA: Mixture of Scientific LoRAs for Cross-Domain Lay Paraphrasingcited by 3
- 2024ATLAS: Improving Lay Summarisation with Attribute-based Controlcited by 2
- 2025Are LLM-generated plain language summaries truly understandable? A large-scale crowdsourced evaluationcited by 2
- 2023Lay Text Summarisation Using Natural Language Processing: A Narrative Literature Reviewcited by 1
- 2024Health Text Simplification: An Annotated Corpus for Digestive Cancer Education and Novel Strategies for Reinforcement Learningcited by 1
- 2024Large Language Models for Biomedical Text Simplification: Promising But Not There Yetcited by 1
- 2025Designing Beyond Language: Sociotechnical Barriers in AI Health Technologies for Limited English Proficiencycited by 1
- 2025PERCS: Persona-Guided Controllable Biomedical Summarization Datasetcited by 1
- 2024Two-Pronged Human Evaluation of ChatGPT Self-Correction in Radiology Report Simplificationcited by 0
- 2025Explain Less, Understand More: Data-Efficient Personalization of Reader-Dependent Jargonscited by 0
- 2025Breaking the Curse of Knowledge: Designing Personalized Jargon Support for Real-Time Online Meetingscited by 0
- 2025Mapping Scientific Literature with Large Language Models and Topic Modelingcited by 0
- 2026Who Does What? Archetypes of Roles Assigned to LLMs During Human-AI Decision-Makingcited by 0
- 2026Explain Like I'm 5 or Whatever I Choose: Evaluating the Potential for Interactive Complexity in Language Model Responsescited by 0
- 2026CWF: A Collaborative Writing Framework for Personalized and Reliable Popular Science Writingcited by 0
- 2026Enhancing Accessibility of Medical Texts through Large Language Model-Driven Plain Language Adaptationcited by 0
- 2026Enhancing Accessibility of Medical Texts through Large Language Model-Driven Plain Language Adaptation15 Sep 2026
- 2026CWF: A Collaborative Writing Framework for Personalized and Reliable Popular Science Writing5 Sep 2026
- 2026Explain Like I'm 5 or Whatever I Choose: Evaluating the Potential for Interactive Complexity in Language Model Responses5 Jun 2026
- 2026Improving Clinical Diagnosis with Counterfactual Multi-Agent Reasoning29 Mar 2026
- 2026Who Does What? Archetypes of Roles Assigned to LLMs During Human-AI Decision-Making12 Feb 2026
- 2025PERCS: Persona-Guided Controllable Biomedical Summarization Dataset3 Dec 2025
- 2025Designing Beyond Language: Sociotechnical Barriers in AI Health Technologies for Limited English Proficiency10 Nov 2025
- 2025Mapping Scientific Literature with Large Language Models and Topic Modeling17 Oct 2025
- 2025Evaluating the Evaluators: Are readability metrics good measures of readability?26 Aug 2025
- 2025Breaking the Curse of Knowledge: Designing Personalized Jargon Support for Real-Time Online Meetings13 Aug 2025
- 2025MedReadCtrl: Personalizing medical text generation with readability-controlled instruction learning10 Jul 2025
- 2025Sci-LoRA: Mixture of Scientific LoRAs for Cross-Domain Lay Paraphrasing24 May 2025
34 more
- 2025Explain Less, Understand More: Data-Efficient Personalization of Reader-Dependent Jargons22 May 2025
- 2025Are LLM-generated plain language summaries truly understandable? A large-scale crowdsourced evaluation15 May 2025
- 2025Multimodal Large Language Models for Medicine: A Comprehensive Survey29 Apr 2025
- 2025Explanatory Summarization with Discourse-Driven Planning27 Apr 2025
- 2025PlainQAFact: Retrieval-augmented Factual Consistency Evaluation Metric for Biomedical Plain Language Summarization11 Mar 2025
- 2025Explainable AI for Clinical Outcome Prediction: A Survey of Clinician Perceptions and Preferences27 Feb 2025
- 2024BioMistral-NLU: Towards More Generalizable Medical Language Understanding through Instruction Tuning24 Oct 2024
- 2024Evaluation of Large Language Models for Summarization Tasks in the Medical Domain: A Narrative Review26 Sep 2024
- 2024Large Language Models for Biomedical Text Simplification: Promising But Not There Yet7 Aug 2024
- 2024Two-Pronged Human Evaluation of ChatGPT Self-Correction in Radiology Report Simplification27 Jun 2024
- 2024ReadCtrl: Personalizing text generation with readability-controlled instruction learning13 Jun 2024
- 2024ATLAS: Improving Lay Summarisation with Attribute-based Control9 Jun 2024
- 2024SciNews: From Scholarly Complexities to Public Narratives -- A Dataset for Scientific News Report Generation26 Mar 2024
- 2024Health Text Simplification: An Annotated Corpus for Digestive Cancer Education and Novel Strategies for Reinforcement Learning26 Jan 2024
- 2023README: Bridging Medical Jargon and Lay Understanding for Patient Education through Data-Centric NLP24 Dec 2023
- 2023Personalized Jargon Identification for Enhanced Interdisciplinary Communication16 Nov 2023
- 2023Pearl: Personalizing Large Language Model Writing Assistants with Generation-Calibrated Retrievers15 Nov 2023
- 2023Enhancing Biomedical Lay Summarisation with External Knowledge Graphs24 Oct 2023
- 2023Generating Summaries with Controllable Readability Levels16 Oct 2023
- 2023A Survey of Large Language Models for Healthcare: from Data, Technology, and Applications to Accountability and Ethics9 Oct 2023
- 2023Overview of the BioLaySumm 2023 Shared Task on Lay Summarization of Biomedical Research Articles29 Sep 2023
- 2023Investigating Large Language Models and Control Mechanisms to Improve Text Readability of Biomedical Abstracts22 Sep 2023
- 2023How Far Can Camels Go? Exploring the State of Instruction Tuning on Open Resources7 Jun 2023
- 2023APPLS: Evaluating Evaluation Metrics for Plain Language Summarization23 May 2023
- 2023Multilingual Simplification of Medical Texts21 May 2023
- 2023A Survey for Biomedical Text Summarization: From Pre-trained to Large Language Models18 Apr 2023
- 2023Lay Text Summarisation Using Natural Language Processing: A Narrative Literature Review24 Mar 2023
- 2023LongEval: Guidelines for Human Evaluation of Faithfulness in Long-form Summarization30 Jan 2023
- 2022A Survey on Medical Document Summarization3 Dec 2022
- 2022Retrieval augmentation of large language models for lay language generation7 Nov 2022
- 2022Making Science Simple: Corpora for the Lay Summarisation of Scientific Literature18 Oct 2022
- 2022Readability Controllable Biomedical Document Summarization10 Oct 2022
- 2022Paper Plain: Making Medical Research Papers Approachable to Healthcare Consumers with Natural Language Processing28 Feb 2022
- 2021Pre-trained Language Models in Biomedical Domain: A Systematic Survey11 Oct 2021
- 2023How Far Can Camels Go? Exploring the State of Instruction Tuning on Open Resourcescited by 407
- 2023A Survey of Large Language Models for Healthcare: from Data, Technology, and Applications to Accountability and Ethicscited by 163
- 2023LongEval: Guidelines for Human Evaluation of Faithfulness in Long-form Summarizationcited by 96
- 2023Pearl: Personalizing Large Language Model Writing Assistants with Generation-Calibrated Retrieverscited by 92
- 2021Pre-trained Language Models in Biomedical Domain: A Systematic Surveycited by 87
- 2022Making Science Simple: Corpora for the Lay Summarisation of Scientific Literaturecited by 54
- 2023Generating Summaries with Controllable Readability Levelscited by 24
- 2022Paper Plain: Making Medical Research Papers Approachable to Healthcare Consumers with Natural Language Processingcited by 23
- 2022Retrieval augmentation of large language models for lay language generationcited by 21
- 2022Readability Controllable Biomedical Document Summarizationcited by 19
- 2023README: Bridging Medical Jargon and Lay Understanding for Patient Education through Data-Centric NLPcited by 17
- 2023APPLS: Evaluating Evaluation Metrics for Plain Language Summarizationcited by 15
12 most cited of 43 All 43 (JSON)
- 2026Enhancing Accessibility of Medical Texts through Large Language Model-Driven Plain Language Adaptation15 Sep 2026
- 2026CWF: A Collaborative Writing Framework for Personalized and Reliable Popular Science Writing5 Sep 2026
- 2026Explain Like I'm 5 or Whatever I Choose: Evaluating the Potential for Interactive Complexity in Language Model Responses5 Jun 2026
- 2026Who Does What? Archetypes of Roles Assigned to LLMs During Human-AI Decision-Making12 Feb 2026
- 2025PERCS: Persona-Guided Controllable Biomedical Summarization Dataset3 Dec 2025
- 2025Designing Beyond Language: Sociotechnical Barriers in AI Health Technologies for Limited English Proficiency10 Nov 2025
- 2025Mapping Scientific Literature with Large Language Models and Topic Modeling17 Oct 2025
- 2025Evaluating the Evaluators: Are readability metrics good measures of readability?26 Aug 2025
- 2025Breaking the Curse of Knowledge: Designing Personalized Jargon Support for Real-Time Online Meetings13 Aug 2025
- 2025MedReadCtrl: Personalizing medical text generation with readability-controlled instruction learning10 Jul 2025
- 2025Sci-LoRA: Mixture of Scientific LoRAs for Cross-Domain Lay Paraphrasing24 May 2025
- 2025Explain Less, Understand More: Data-Efficient Personalization of Reader-Dependent Jargons22 May 2025
12 newest of 43 All 43 (JSON)