Historical-Feature Residual Adaptation for Sequential Screening
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Abstract (arXiv)
Sequential screening policies must use acquired feedback effectively under a fixed experiment budget. We study acquisition-time residual adaptation: a small ranking correction built from fixed historical features and anchored to base scores recorded before feedback is revealed. The interface accepts a history-conditioned scorer and a candidate feature table; its primary instantiation augments AssayFormer's ten-dimensional representation with 64 historical directions while retaining the pretrained model. In retrospective evaluation on 20 official-test screens from 15 recorded sources, a comparison fixed before target-outcome access increased source-macro fraction of hits recovered from 22.58% to 28.61%, exceeding all six prespecified comparators. A same-feature ordinary ranking head achieved 25.73%. Supplementary strong logistic, rank-fusion, and unprojected controls achieved 26.42%, 26.02%, and 26.78%, respectively. A separate model-independent pilot on 13 reused development screens reconstructs the features without AssayFormer assets. Across three seeds, residual adaptation improves random-forest hit recovery from 28.87% to 31.27%, while logistic recovery changes from 30.22% to 29.78%. The results show effective pretrained-policy adaptation and useful transfer to an independent nonlinear base, with gains that depend on the base model.
Key facts. No citing papers in the map yet (data through 14 Oct 2026). Builds on 8 of its 15 references that are in the map. First posted on arXiv 13 Oct 2026.
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References · 8
- 2017Attention Is All You Needcited by 60,361
- 2015Deep Residual Learning for Image Recognitioncited by 52,096
- 2021UNETR: Transformers for 3D Medical Image Segmentationcited by 959
- 2017Learning Active Learning from Datacited by 101
- 2019Model Adaptation via Model Interpolation and Boosting for Web Search Rankingcited by 3
- 2026AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agentscited by 3
- 2026Test-Time Optimization of Query Embeddings with Ranking Aware Reward Maximizationcited by 2
- 2026Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screenscited by 1
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