mlsanityData to 14 Oct 2026

Right Answer, Wrong Reason: Accuracy, Consistency, and Consensus Are Misleading Indicators of LLM Faithfulness in Clinical Decision Support

arXiv 2609.32817 ↗First posted 26 Sep 2026cs.AIcited by 0

On the map: LLM reasoning → Clinical and biomedical applications

Abstract (arXiv)

Clinical Large Language Models (LLMs) achieve strong medical-exam accuracy; however, a correct answer does not guarantee that the explanation names the concepts that actually drove the decision. We introduce three lightweight, directly interpretable metrics for this faithfulness gap: the Explanation Stability Index (ESI), which measures reasoning consistency across repeated queries; the Causal Faithfulness Score (CFS), which tests whether cited concepts drive predictions via concept ablation; and the Perturbation Stability Score (PSS), which measures robustness to semantic-preserving paraphrases. By evaluating six LLMs on 150 MedQA-USMLE questions (900 model-question observations), we found that only 23.3% of the cited clinical concepts were causally necessary. Correct answers had lower CFS than incorrect answers (0.212 vs. 0.398), answer consistency negatively predicted CFS (Spearman r = -0.466), and model pairs could agree on answers while sharing only 8.8% of cited reasoning concepts. These results show that accuracy, consistency, and consensus are incomplete safety signals for clinical decision-making support. The evidence is behavioral rather than mechanistic: concept ablation tests counterfactual sensitivity of outputs, not internal circuits.

Key facts. No citing papers in the map yet (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 18 of its 24 references that are in the map. First posted on arXiv 26 Sep 2026.

Builds on

18 of 24 references.

References · 18

  1. 2022Chain-of-Thought Prompting Elicits Reasoning in Large Language Modelscited by 12,459
  2. 2019Sentence-BERT: Sentence Embeddings using Siamese BERT-Networkscited by 9,170
  3. 2017A Unified Approach to Interpreting Model Predictionscited by 6,555
  4. 2022Self-Consistency Improves Chain of Thought Reasoning in Language Modelscited by 5,708
  5. 2016"Why Should I Trust You?": Explaining the Predictions of Any Classifiercited by 5,070
  6. 2017On Calibration of Modern Neural Networkscited by 4,960
  7. 2022Survey of Hallucination in Natural Language Generationcited by 2,075
  8. 2022Large Language Models Encode Clinical Knowledgecited by 1,830
  9. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,356
  10. 2023Language Models Don't Always Say What They Think: Unfaithful Explanations in Chain-of-Thought Promptingcited by 1,122
  11. 2023Measuring Faithfulness in Chain-of-Thought Reasoningcited by 703
  12. 2019ERASER: A Benchmark to Evaluate Rationalized NLP Modelscited by 530
6 more
  1. 2023Can Generalist Foundation Models Outcompete Special-Purpose Tuning? Case Study in Medicinecited by 329
  2. 2022Towards Faithful Model Explanation in NLP: A Surveycited by 130
  3. 2025Walk the Talk? Measuring the Faithfulness of Large Language Model Explanationscited by 45
  4. 2023Faithful Explanations of Black-box NLP Models Using LLM-generated Counterfactualscited by 44
  5. 2024Cycles of Thought: Measuring LLM Confidence through Stable Explanationscited by 29
  6. 2021Towards a framework for evaluating the safety, acceptability and efficacy of AI systems for health: an initial synthesiscited by 1

Built on by

Not cited yet.

Similar, not cited

Close in wording, no citation either way

  1. 2026Faithful or Just Plausible? Evaluating the Faithfulness of Closed-Source LLMs in Medical Reasoning
  2. 2026CLEAR: Revealing How Noise and Ambiguity Degrade Reliability in LLMs for Medicine
  3. 2025Towards Transparent Reasoning: What Drives Faithfulness in Large Language Models?
  4. 2025Evaluating Large Language Models for Evidence-Based Clinical Question Answering
  5. 2025Limitations of Large Language Models in Clinical Problem-Solving Arising from Inflexible Reasoning
  6. 2024IITK at SemEval-2024 Task 2: Exploring the Capabilities of LLMs for Safe Biomedical Natural Language Inference for Clinical Trials
  7. 2026Measuring Epistemic Resilience of LLMs Under Misleading Medical Context
  8. 2026Towards Reliable Medical LLMs: Benchmarking and Enhancing Confidence Estimation of Large Language Models in Medical Consultation