mlsanityData to 7 Oct 2026

SMARtCARE: Privacy-Preserving Agentic AI Systems for Bounded-Autonomy Clinical Decision Support

arXiv 2609.31763 ↗First posted 24 Sep 2026cs.AI cs.ET cs.SEcited by 0

On the map: LLM agents and tool use → Medical and scientific domain agents

Abstract (arXiv)

Long-context clinical AI systems can miss relevant patient history when prior admissions fall outside the active reasoning context. In ICU monitoring, this can cause early vital-sign drift to appear nonspecific even when it resembles a prior deterioration pattern. SMARtCARE addresses this gap through a four-state clinical decision-support architecture: Stable, Meta-cognitive, Assisted, and Regulated (Revoked). Rather than automatically retrieving prior records, SMARtCARE uses a lossy six-channel fingerprint of the patient's prior trajectory. When current drift matches that fingerprint and the prior record is absent from context, the system raises a Meta-cognitive escalation for clinician review; full retrieval occurs only through clinician action in the Assisted state. A patient-identity guard is designed to enforce correct attribution across data loading, logging, and audit layers. Evaluation combines a synthetic Monte Carlo study that validates the state-transition logic and estimator stability, not clinical performance, with real-data runs on both the MIMIC-III and MIMIC-IV Clinical Database Demos. On MIMIC-III, one prior-pattern recurrence was identified among 14 two-admission patients; on MIMIC-IV, the same pipeline produced no fingerprint matches among 9 two-admission patients, which illustrates a key limitation of a fixed canonical pattern library. Across both runs all logged decisions were fully traceable and correctly attributed. The results support SMARtCARE as a traceable, privacy-aware mechanism for surfacing middle-context risk; they are not a clinical efficacy claim.

Key facts. No citing papers in the map yet (data through 7 Oct 2026). Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use. Builds on 8 of its 23 references that are in the map. First posted on arXiv 24 Sep 2026.

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8 of 23 references.

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Same direction, newest first

  1. 2026TrajOnco: a multi-agent framework for temporal reasoning over longitudinal EHR for multi-cancer early detection12 Apr

Other references · 7

  1. 2017Attention Is All You Needcited by 59,932
  2. 2023Lost in the Middle: How Language Models Use Long Contextscited by 3,383
  3. 2017Multitask learning and benchmarking with clinical time series datacited by 287
  4. 2018Scalable and accurate deep learning for electronic health recordscited by 275
  5. 2025TIMER: Temporal Instruction Modeling and Evaluation for Longitudinal Clinical Recordscited by 33
  6. 2024DiReCT: Diagnostic Reasoning for Clinical Notes via Large Language Modelscited by 14
  7. 2026Intelligence as Managed Autonomy: Failure, Escalation, and Governance for Agentic AI Systemscited by 2

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  1. 2026Vital Trace: Protocol-Constrained Patient-State Reasoning for Longitudinal Clinical Trajectories
  2. 2026CARE: Privacy-Compliant Agentic Reasoning with Evidence Discordance
  3. 2026RealICU: Do LLM Agents Understand Long-Context ICU Data? A Benchmark Beyond Behavior Imitation
  4. 2026CodeClinic: Evaluating Automation of Coding Skills for Clinical Reasoning Agents
  5. 2026Grounding Clinical AI Competency in Human Cognition Through the Clinical World Model and Skill-Mix Framework
  6. 2026Generated Context versus Governed State: Functional Conditions for Accountable Longitudinal Clinical Reasoning
  7. 2025Patient-Zero: Scaling Synthetic Patient Agents to Real-World Distributions without Real Patient Data
  8. 2026Agentic AI-based Framework for Mitigating Premature Diagnostic Handoff and Silent Hallucination in Healthcare Applications