SMARtCARE: Privacy-Preserving Agentic AI Systems for Bounded-Autonomy Clinical Decision Support
On the map: LLM agents and tool use → Medical and scientific domain agents
Abstract (arXiv)
Long-context clinical AI systems can miss relevant patient history when prior admissions fall outside the active reasoning context. In ICU monitoring, this can cause early vital-sign drift to appear nonspecific even when it resembles a prior deterioration pattern. SMARtCARE addresses this gap through a four-state clinical decision-support architecture: Stable, Meta-cognitive, Assisted, and Regulated (Revoked). Rather than automatically retrieving prior records, SMARtCARE uses a lossy six-channel fingerprint of the patient's prior trajectory. When current drift matches that fingerprint and the prior record is absent from context, the system raises a Meta-cognitive escalation for clinician review; full retrieval occurs only through clinician action in the Assisted state. A patient-identity guard is designed to enforce correct attribution across data loading, logging, and audit layers. Evaluation combines a synthetic Monte Carlo study that validates the state-transition logic and estimator stability, not clinical performance, with real-data runs on both the MIMIC-III and MIMIC-IV Clinical Database Demos. On MIMIC-III, one prior-pattern recurrence was identified among 14 two-admission patients; on MIMIC-IV, the same pipeline produced no fingerprint matches among 9 two-admission patients, which illustrates a key limitation of a fixed canonical pattern library. Across both runs all logged decisions were fully traceable and correctly attributed. The results support SMARtCARE as a traceable, privacy-aware mechanism for surfacing middle-context risk; they are not a clinical efficacy claim.
Key facts. No citing papers in the map yet (data through 7 Oct 2026). Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use. Builds on 8 of its 23 references that are in the map. First posted on arXiv 24 Sep 2026.
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- 2017Attention Is All You Needcited by 59,932
- 2023Lost in the Middle: How Language Models Use Long Contextscited by 3,383
- 2017Multitask learning and benchmarking with clinical time series datacited by 287
- 2018Scalable and accurate deep learning for electronic health recordscited by 275
- 2025TIMER: Temporal Instruction Modeling and Evaluation for Longitudinal Clinical Recordscited by 33
- 2024DiReCT: Diagnostic Reasoning for Clinical Notes via Large Language Modelscited by 14
- 2026Intelligence as Managed Autonomy: Failure, Escalation, and Governance for Agentic AI Systemscited by 2
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- 2026Grounding Clinical AI Competency in Human Cognition Through the Clinical World Model and Skill-Mix Framework
- 2026Generated Context versus Governed State: Functional Conditions for Accountable Longitudinal Clinical Reasoning
- 2025Patient-Zero: Scaling Synthetic Patient Agents to Real-World Distributions without Real Patient Data
- 2026Agentic AI-based Framework for Mitigating Premature Diagnostic Handoff and Silent Hallucination in Healthcare Applications