mlsanityData to 14 Oct 2026

When Edit Flows are Edit Jumps: replicating Edit Flows and EvoFlows

arXiv 2609.18745 ↗First posted 16 Sep 2026cs.LG stat.MLcited by 0

Not on the map. Why?

Abstract (arXiv)

Antibody lead optimization calls for a small, bounded set of edits to an existing candidate: substitutions, but also insertions and deletions. Edit-based generative models are the only ones that allocate such an edit budget without fixing the edit positions, the edit count, or the output length in advance. However, the existing approaches Edit Flows and EvoFlows did not release code or complete training specifications. Here, we show that both methods follow the same underlying process -- edits firing one at a time, at learned rates, in continuous time -- the pure-jump case of generator matching over finite sequences. With EditJumps we introduce the first open implementation of this framework, with a single generalist antibody editor trained on 1.66M Observed Antibody Space homolog pairs to propose homolog-like variants of a seed sequence, editing unseen leads zero-shot, without the per-family retraining original approaches require. Replicating this system from scratch exposes why open code is essential for generative biology: reconciling published edit distributions required reverse-engineering an undocumented rate-scaling hyperparameter that dictates realized mutation counts. Moreover, we show that published evaluation metrics are highly sensitive to reference sample size, frequently flipping method rankings. We release our full codebase, automated test suite, and configurations at: https://github.com/VisiumCH/editjumps

Key facts. No citing papers in the map yet (data through 14 Oct 2026). Builds on 14 of its 28 references that are in the map. First posted on arXiv 16 Sep 2026.

Builds on

14 of 28 references.

References · 14

  1. 2020Denoising Diffusion Probabilistic Modelscited by 21,076
  2. 2024The Llama 3 Herd of Modelscited by 14,715
  3. 2015Deep Unsupervised Learning using Nonequilibrium Thermodynamicscited by 7,058
  4. 2022Flow Matching for Generative Modelingcited by 5,702
  5. 2021Structured Denoising Diffusion Models in Discrete State-Spacescited by 1,719
  6. 2023Discrete Diffusion Modeling by Estimating the Ratios of the Data Distributioncited by 745
  7. 2024Discrete Flow Matchingcited by 317
  8. 2022The Vendi Score: A Diversity Evaluation Metric for Machine Learningcited by 311
  9. 2024Generative Flows on Discrete State-Spaces: Enabling Multimodal Flows with Applications to Protein Co-Designcited by 305
  10. 2019Levenshtein Transformercited by 199
  11. 2019Insertion Transformer: Flexible Sequence Generation via Insertion Operationscited by 125
  12. 2024Generator Matching: Generative modeling with arbitrary Markov processescited by 86
2 more
  1. 2023Protein Discovery with Discrete Walk-Jump Samplingcited by 38
  2. 2026EvoFlows: Evolutionary Edit-Based Flow-Matching for Protein Engineeringcited by 4

Built on by

Not cited yet.