mlsanityData to 14 Oct 2026

Target leakage, not model class, explains reported accuracy in survey-based cardiovascular screening: a leakage-tiered audit of glass-box and tabular foundation models

arXiv 2609.11838 ↗First posted 10 Sep 2026cs.CLcited by 0

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Abstract (arXiv)

Cardiovascular screening models trained on national health surveys routinely report areas under the receiver operating characteristic curve (AUROC) near 0.89. We asked whether that accuracy reflects learning or target leakage, whether tabular foundation models change the answer, and whether the properties deployment requires survive joint examination. We benchmarked ten classifiers spanning linear, tree-ensemble, neural, glass-box, and tabular foundation classes for prevalent myocardial infarction in 442,067 respondents of the 2022 Behavioral Risk Factor Surveillance System across five feature tiers of decreasing leakage risk. Each was audited for discrimination, calibration, fairness at an explicit screening threshold, conformal coverage, explanation faithfulness, and inference cost, then applied -- models and thresholds frozen -- to 430,755 respondents of 2023. Removing two post-diagnostic features cost every model 0.049-0.051 AUROC, collapsing the field into a 0.0045-wide band. The glass-box explainable boosting machine was non-inferior to every alternative within a pre-specified 0.005 margin while scoring the cohort roughly 104 times faster than the strongest foundation model. One threshold detected 75.4% of women's infarctions against 89.0% of men's; editing the model's shape functions reduced the gap to 0.010. Marginal conformal prediction gave 0.86 coverage to men and 0.82 to adults over 60; Mondrian calibration repaired every stratum. Frozen models transported within 0.002 AUROC. Reported headroom in this literature is a property of the feature set, not the learner. Transparency cost nothing measurable and made fairness repair and uncertainty conditioning directly auditable. Evaluation practice, not model capacity, is the binding constraint.

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References · 6

  1. 2017A Unified Approach to Interpreting Model Predictionscited by 6,555
  2. 2025TabICL: A Tabular Foundation Model for In-Context Learning on Large Datacited by 289
  3. 2019InterpretML: A Unified Framework for Machine Learning Interpretabilitycited by 246
  4. 2023Conformal Prediction With Conditional Guaranteescited by 152
  5. 2022Interpretability, Then What? Editing Machine Learning Models to Reflect Human Knowledge and Valuescited by 25
  6. 2024Fairness-Aware Interpretable Modeling (FAIM) for Trustworthy Machine Learning in Healthcarecited by 2

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