Data-Efficient Networks for Multi-Contrast MRI Reconstruction based on a Generalized Content/Style Prior

Multi-contrast MR scans contain redundant structural information that can be leveraged during reconstruction and potentially accelerate acquisition times. This idea has inspired end-to-end guided reconstruction models, leveraging one or more contrasts to guide the reconstruction of a different contrast. However, these models require large paired multi-contrast raw datasets for training, limiting their application in low-data regimes. In this work, we propose a modular framework, namely CoSMo-RecNet, for learning guided reconstruction models in the low-data regime. At its core is a reusable multi-contrast representation based on a content/style model, which can be learned from large-scale, publicly accessible, unpaired multi-contrast image datasets, without available k-space data. Using this frozen model as a multi-contrast prior and using a set of reference contrasts, the reconstruction problem reduces to a much simpler refinement problem that can be solved by a lightweight unrolled network and thus learned from small, task-specific reconstruction datasets. We demonstrate the efficacy of CoSMo-RecNet by evaluating it on the low-field 0.3 T M4Raw dataset, showing stable reconstruction quality on decreasing the raw training data budget. CoSMo-RecNet achieved higher reconstruction quality with 5 training subjects or lower compared to a parameter-count-matched MoDL trained on 100 subjects. On a data-limited and severely out-of-distribution ultra-low-field 47 mT Halbach scanner dataset, CoSMo-RecNet was superior to other viable strategies, including classical reconstruction, transfer learning, and zero-shot reconstruction.