Beyond Static Anchors: Bounded Prototype Conditioning for Language-Free Medical Anomaly Detection
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Abstract (arXiv)
Medical anomaly detection identifies abnormal images and localizes lesions under scarce supervision while generalizing across organs and modalities. Existing CLIP-based methods reduce annotation requirements through vision--language alignment, but their normal and abnormal references, whether text prompts or learned visual tokens, remain fixed across test images. Such static references may not transfer reliably to unseen targets in a cross-domain medical imaging scenario. To address this, we propose ReCAP, a language-free framework that replaces static anchors with input-conditioned visual prototypes. ReCAP re-centers separated normal and abnormal prototypes for each image through a bounded gated modulation, enabling query-adaptive anomaly scoring while constraining context-induced prototype drift. For the few-shot setting, we introduce a non-parametric normal-reference memory to preserve instance-level target-domain variation and complement the conditional prototype branch. Across six medical benchmarks, ReCAP achieves the best image-level AUROC on all zero-shot and 23 of 24 few-shot settings, and the best zero-shot pixel-level AUROC on all three segmentation datasets. Particularly, it reduces inference latency by over 70% compared to the fastest baseline, without text prompts or test-time gradient updates.
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References · 17
- 2017ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseasescited by 972
- 2021Towards Total Recall in Industrial Anomaly Detectioncited by 776
- 2017Unsupervised Anomaly Detection with Generative Adversarial Networks to Guide Marker Discoverycited by 566
- 2019Memorizing Normality to Detect Anomaly: Memory-augmented Deep Autoencoder for Unsupervised Anomaly Detectioncited by 564
- 2019The Liver Tumor Segmentation Benchmark (LiTS)cited by 509
- 2022Anomaly Detection via Reverse Distillation from One-Class Embeddingcited by 421
- 2022Diffusion Models for Medical Anomaly Detectioncited by 232
- 2018Adversarially Learned One-Class Classifier for Novelty Detectioncited by 202
- 2022Catching Both Gray and Black Swans: Open-set Supervised Anomaly Detectioncited by 104
- 2025AA-CLIP: Enhancing Zero-shot Anomaly Detection via Anomaly-Aware CLIPcited by 73
- 2025One-for-More: Continual Diffusion Model for Anomaly Detectioncited by 19
- 2026VisualAD: Language-Free Zero-Shot Anomaly Detection via Vision Transformercited by 11
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- 2025Distribution Prototype Diffusion Learning for Open-set Supervised Anomaly Detectioncited by 10
- 2025MadCLIP: Few-shot Medical Anomaly Detection with CLIPcited by 10
- 2025UltraAD: Fine-Grained Ultrasound Anomaly Classification via Few-Shot CLIP Adaptationcited by 5
- 2026One Language-Free Foundation Model Is Enough for Universal Vision Anomaly Detectioncited by 4
- 2025IQE-CLIP: Instance-aware Query Embedding for Zero-/Few-shot Anomaly Detection in Medical Domaincited by 1
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