mlsanityData to 14 Oct 2026

Possible or Definite? A Benchmark for Evaluating Diagnostic Uncertainty Preservation in Clinical Text

arXiv 2606.18471 ↗First posted 16 Jun 2026cs.CLcited by 4

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Abstract (arXiv)

Large language models (LLMs) are increasingly used for clinical text tasks such as summarization and revision. While most studies evaluate the fluency and coherence of LLM-generated text, whether LLMs correctly preserve diagnostic uncertainty remains underexplored. In clinical practice, phrases such as ``possible pneumonia'' communicate the strength of available evidence and directly guide decisions about follow-up testing and treatment. Altering these uncertainty expressions can change the clinical meaning entirely. In this paper, we systematically evaluated this problem in two steps. First, we constructed a benchmark of 1,200 clinical documents with 9,184 uncertainty annotations across five levels. Second, we evaluated three LLMs on this benchmark. Our results show that (1) LLMs preserve the original uncertainty cues poorly, often less than half the time; (2) LLMs struggle with nuanced distinctions between adjacent levels. This work reveals a failure mode not captured by standard evaluation metrics and provides implications for the safe deployment of LLMs in clinical workflows.

Key facts. Cited by 4 papers in the map (data through 14 Oct 2026). Builds on 14 of its 38 references that are in the map. First posted on arXiv 16 Jun 2026.

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14 of 38 references.

References · 14

  1. 2022Language Models (Mostly) Know What They Knowcited by 1,856
  2. 2023Adapted Large Language Models Can Outperform Medical Experts in Clinical Text Summarizationcited by 246
  3. 2023Opportunities and Challenges for ChatGPT and Large Language Models in Biomedicine and Healthcited by 118
  4. 2017NegBio: a high-performance tool for negation and uncertainty detection in radiology reportscited by 79
  5. 2021Launching into clinical space with medspaCy: a new clinical text processing toolkit in Pythoncited by 40
  6. 2024EHRNoteQA: An LLM Benchmark for Real-World Clinical Practice Using Discharge Summariescited by 35
  7. 2024Overview of the First Shared Task on Clinical Text Generation: RRG24 and "Discharge Me!"cited by 20
  8. 2024LoGU: Long-form Generation with Uncertainty Expressionscited by 19
  9. 2022DR.BENCH: Diagnostic Reasoning Benchmark for Clinical Natural Language Processingcited by 14
  10. 2024Large Language Models in the Clinic: A Comprehensive Benchmarkcited by 13
  11. 2023Overview of the Problem List Summarization (ProbSum) 2023 Shared Task on Summarizing Patients' Active Diagnoses and Problems from Electronic Health Record Progress Notescited by 11
  12. 2025UNCLE: Benchmarking Uncertainty Expressions in Long-Form Generationcited by 11
2 more
  1. 2025Uncertainty-Aware Large Language Models for Explainable Disease Diagnosiscited by 9
  2. 2020NUBES: A Corpus of Negation and Uncertainty in Spanish Clinical Textscited by 4

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4 papers.