MedCase-Structured: A Text-to-FHIR Dataset for Benchmarking Diagnostic Reasoning in Clinically Realistic EHR Settings
On the map: LLM reasoning → Clinical and biomedical applications
Abstract (arXiv)
Large language models (LLMs) show promise for clinical reasoning and decision support, but evaluation in structured, electronic health record-congruent settings remains limited. Existing benchmarks often rely on static datasets or unstructured inputs that do not reflect the interoperable data formats used in clinical systems. We introduce a reusable pipeline for generating terminology-grounded HL7 FHIR R4 bundles from unstructured text, enabling controllable evaluation of clinical decision support systems over structured inputs. The pipeline combines staged LLM generation with terminology-grounded validation and repair to eliminate hallucinated codes and enforce structural and semantic consistency. Applying this approach to MedCaseReasoning, we construct MedCase-Structured, a synthetic dataset of 1,732 FHIR bundles derived from clinician-authored diagnostic cases, producing complete, valid bundles for 97.1% of attempted cases. Evaluation on MedCase-Structured reveals consistently lower diagnostic accuracy for LLMs on structured FHIR inputs than with plain text, highlighting the importance of deployment-aligned benchmarking.
Key facts. Cited by 1 paper in the map (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 6 of its 28 references that are in the map. First posted on arXiv 28 May 2026.
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- 2017Billion-scale similarity search with GPUscited by 2,497
- 2020Self-Alignment Pretraining for Biomedical Entity Representationscited by 237
- 2025FHIR-AgentBench: Benchmarking LLM Agents for Realistic Interoperable EHR Question Answeringcited by 22
- 2025EHRStruct: A Comprehensive Benchmark Framework for Evaluating Large Language Models on Structured Electronic Health Record Taskscited by 6
- 2026Evaluation format, not model capability, drives measured triage failure in the assessment of consumer health AIcited by 1
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- 2025Enhancing Clinical Decision Support and EHR Insights through LLMs and the Model Context Protocol: An Open-Source MCP-FHIR Framework
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- 2025MediEval: A Unified Medical Benchmark for Patient-Contextual and Knowledge-Grounded Reasoning in LLMs
- 2026EHR-RAG: Bridging Long-Horizon Structured Electronic Health Records and Large Language Models via Enhanced Retrieval-Augmented Generation
- 2026ChatHealthAI: Aligning Electronic Health Record Representations with Large Language Models for Grounded Clinical Reasoning