mlsanityData to 14 Oct 2026

Are We Overconfident in Models and Results for Semi-Supervised 3D Medical Image Segmentation?

arXiv 2605.25561 ↗First posted 25 May 2026cs.CVcited by 0

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Abstract (arXiv)

Semi-supervised learning has become a dominant paradigm for reducing annotation costs. However, we argue that the current progress is clouded by a twofold overconfidence problem. Algorithmically, mainstream pseudo-labeling frameworks often conflate prediction confidence with uncertainty, leading to severe confirmation bias. Strategically, since multiple benchmark datasets lack dedicated validation sets, some studies use the test set for validation as well, leading to inflated performance estimates. Subsequent methods, compelled to employ the same strategy to surpass reported SOTA, trigger an arms race of overfitting. This raises concerns that the impressive numerical gains in the community may reflect overfitting rather than genuine progress. Thus, we propose a tri-space calibrated segmentation framework founded on a principled dual-axis reliability assessment engine. It explicitly decouples confidence from uncertainty and uses this signal to detect and correct confirmation bias across feature, probability, and image spaces in a collaborative manner. Across three benchmark datasets, TCSeg consistently delivers strong performance under existing evaluation protocols. More importantly, we advocate that the community report final-checkpoint results under multiple-run protocols, thereby establishing more rigorous benchmarks with a more realistic perspective. Code will be available: github.com/DirkLiii/TCSeg.

Key facts. No citing papers in the map yet (data through 14 Oct 2026). Builds on 26 of its 47 references that are in the map. First posted on arXiv 25 May 2026.

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26 of 47 references.

References · 26

  1. 2017On Calibration of Modern Neural Networkscited by 4,960
  2. 2014Fully Convolutional Networks for Semantic Segmentationcited by 4,859
  3. 2015Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learningcited by 4,448
  4. 2019Self-supervised Visual Feature Learning with Deep Neural Networks: A Surveycited by 657
  5. 2019Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentationcited by 379
  6. 2020Semi-supervised Medical Image Segmentation through Dual-task Consistencycited by 216
  7. 2015DeepOrgan: Multi-level Deep Convolutional Networks for Automated Pancreas Segmentationcited by 159
  8. 2019Transformation Consistent Self-ensembling Model for Semi-supervised Medical Image Segmentationcited by 140
  9. 2021Mutual Consistency Learning for Semi-supervised Medical Image Segmentationcited by 108
  10. 2020Efficient Semi-Supervised Gross Target Volume of Nasopharyngeal Carcinoma Segmentation via Uncertainty Rectified Pyramid Consistencycited by 102
  11. 2020Annotation-efficient deep learning for automatic medical image segmentationcited by 79
  12. 2021Inconsistency-aware Uncertainty Estimation for Semi-supervised Medical Image Segmentationcited by 61
14 more
  1. 2023Rethinking Semi-Supervised Medical Image Segmentation: A Variance-Reduction Perspectivecited by 43
  2. 2023Towards Generic Semi-Supervised Framework for Volumetric Medical Image Segmentationcited by 35
  3. 2021Uncertainty guided semi-supervised segmentation of retinal layers in OCT imagescited by 29
  4. 2021All-Around Real Label Supervision: Cyclic Prototype Consistency Learning for Semi-supervised Medical Image Segmentationcited by 25
  5. 2021Uncertainty-Guided Mutual Consistency Learning for Semi-Supervised Medical Image Segmentationcited by 22
  6. 2021Pseudo-label refinement using superpixels for semi-supervised brain tumour segmentationcited by 16
  7. 2022Translation Consistent Semi-supervised Segmentation for 3D Medical Imagescited by 13
  8. 2023Anatomically-aware Uncertainty for Semi-supervised Image Segmentationcited by 13
  9. 2023Segment Together: A Versatile Paradigm for Semi-Supervised Medical Image Segmentationcited by 12
  10. 2021Exploring Feature Representation Learning for Semi-supervised Medical Image Segmentationcited by 11
  11. 2024SGTC: Semantic-Guided Triplet Co-training for Sparsely Annotated Semi-Supervised Medical Image Segmentationcited by 4
  12. 2025Generalizable Pancreas Segmentation via a Dual Self-Supervised Learning Frameworkcited by 3
  13. 2025A Dual-Task Synergy-Driven Generalization Framework for Pancreatic Cancer Segmentation in CT Scanscited by 2
  14. 2026Fully Differentiable Bidirectional Dual-Task Synergistic Learning for Semi-Supervised 3D Medical Image Segmentationcited by 1

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