Quantum Knowledge Graph: Modeling Context-Dependent Triplet Validity
On the map: LLM reasoning → Clinical and biomedical applications
Abstract (arXiv)
Knowledge graphs (KGs) are increasingly used to support large lan guage model (LLM) reasoning, but standard triplet-based KGs treat each relation as globally valid. In many settings, whether a relation should count as evidence depends on the context. We therefore formulate triplet validity as a triplet-specific function of context and refer to this formulation as a Quantum Knowledge Graph (QKG). We instantiate QKG in medicine using a diabetes-centered PrimeKG subgraph, whose 68,651 context-sensitive relations are further annotated with patient-group-specific constraints. We evaluate it in a reasoner--validator pipeline for medical question answering on a KG-grounded subset of MedReason containing 2,788 questions. With Haiku-4.5 as both the Reasoner and the Validator, KG-backed validation significantly improves over a no-validator baseline (+0.61 pp), and QKG with context matching yields the largest gain, outperforming both KG validation without context matching (+0.79 pp) and the no-validator baseline (+1.40 pp; paired McNemar, all p<0.05). Under a stronger validator (Qwen-3.6-Plus), the raw QKG gain over the no-validator baseline grows from +1.40 pp to +5.96 pp; the context-matching gap is non-significant (p=0.73) on the raw set but becomes borderline significant (p=0.05) after adjustment for knowledge leakage and suspicious questions, consistent with a benchmark-gold ceiling rather than a QKG limitation. Taken together, the results support the view that the value of a KG in LLM-based clinical reasoning lies not merely in storing medically related facts, but in representing whether those facts are applicable to the specific patient context. For reproducibility and further research, we release the curated QKG datasets and source code.footnotehttps://github.com/HKAI-Sci/QKG
Key facts. No citing papers in the map yet (data through 7 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 8 of its 19 references that are in the map. First posted on arXiv 27 Apr 2026.
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- 2023EHRSHOT: An EHR Benchmark for Few-Shot Evaluation of Foundation Modelscited by 101
- 2021Question Answering Over Temporal Knowledge Graphscited by 99
- 2020Message Passing for Hyper-Relational Knowledge Graphscited by 78
- 2024Can Knowledge Graphs Make Large Language Models More Trustworthy? An Empirical Study Over Open-ended Question Answeringcited by 20
- 2023Temporal Fact Reasoning over Hyper-Relational Knowledge Graphscited by 10
- 2024Assessing the Reasoning Capabilities of LLMs in the context of Evidence-based Claim Verificationcited by 9
- 2025Hybrid Fact-Checking that Integrates Knowledge Graphs, Large Language Models, and Search-Based Retrieval Agents Improves Interpretable Claim Verificationcited by 2
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