Can Virtual Agents Care? Designing an Empathetic and Personalized LLM-Driven Conversational Agent
On the map: LLM agents and tool use → Medical and scientific domain agents
Abstract (arXiv)
Mental health challenges are rising globally, while traditional support services face limited availability and high costs. Large language models offer potential for conversational support, but often lack personalization, empathy, and factual grounding. A virtual agent framework is introduced to provide empathetic, personalized, and reliable wellbeing support through retrieval-augmented architecture, structured memory, and multimodal interaction. Objective benchmarks demonstrate improved retrieval and response quality, particularly for smaller models. A cross-cultural study with university students from Vietnam and Australia shows the system outperforms LLM-only baselines in coherence, perceived accuracy, and empathy, with most participants clearly preferring the proposed approach.
Key facts. No citing papers in the map yet (data through 7 Oct 2026). Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use. Builds on 11 of its 23 references that are in the map. First posted on arXiv 22 Apr 2026.
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11 of 23 references.
References · 11
- 2016SQuAD: 100,000+ Questions for Machine Comprehension of Textcited by 4,115
- 2022Robust Speech Recognition via Large-Scale Weak Supervisioncited by 3,972
- 2020Dense Passage Retrieval for Open-Domain Question Answeringcited by 3,779
- 2020REALM: Retrieval-Augmented Language Model Pre-Trainingcited by 2,126
- 2021WebGPT: Browser-assisted question-answering with human feedbackcited by 1,722
- 2025Qwen3 Embedding: Advancing Text Embedding and Reranking Through Foundation Modelscited by 1,175
- 2020Recipes for building an open-domain chatbotcited by 593
- 2020Towards a Human-like Open-Domain Chatbotcited by 467
- 2025MMTEB: Massive Multilingual Text Embedding Benchmarkcited by 120
- 2023A Systematic Literature Review of User Trust in AI-Enabled Systems: An HCI Perspectivecited by 33
- 2024CLAPNQ: Cohesive Long-form Answers from Passages in Natural Questions for RAG systemscited by 23
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- 2025Investigating AI in Peer Support via Multi-Module System-Driven Embodied Conversational Agents
- 2024"I Like Sunnie More Than I Expected!": Exploring User Expectation and Perception of an Anthropomorphic LLM-based Conversational Agent for Well-Being Support
- 2024The influence of persona and conversational task on social interactions with a LLM-controlled embodied conversational agent
- 2026E3VA: Enhancing Emotional Expressiveness in Virtual Conversational Agents
- 2025Large Language Model-Powered Conversational Agent Delivering Problem-Solving Therapy (PST) for Family Caregivers: Enhancing Empathy and Therapeutic Alliance Using In-Context Learning
- 2025ESC-Judge: A Framework for Comparing Emotional Support Conversational Agents