mlsanityData to 7 Oct 2026

Toward Aristotelian Medical Representations: Backpropagation-Free Layer-wise Analysis for Interpretable Generalized Metric Learning on MedMNIST

arXiv 2604.06017 ↗First posted 7 Apr 2026cs.CVcited by 2

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Abstract (arXiv)

While deep learning has achieved remarkable success in medical imaging, the "black-box" nature of backpropagation-based models remains a significant barrier to clinical adoption. To bridge this gap, we propose Aristotelian Rapid Object Modeling (A-ROM), a framework built upon the Platonic Representation Hypothesis (PRH). This hypothesis posits that models trained on vast, diverse datasets converge toward a universal and objective representation of reality. By leveraging the generalizable metric space of pretrained Vision Transformers (ViTs), A-ROM enables the rapid modeling of novel medical concepts without the computational burden or opacity of further gradient-based fine-tuning. We replace traditional, opaque decision layers with a human-readable concept dictionary and a k-Nearest Neighbors (kNN) classifier to ensure the model's logic remains interpretable. Experiments on the MedMNIST v2 suite demonstrate that A-ROM delivers performance competitive with standard benchmarks while providing a simple and scalable, "few-shot" solution that meets the rigorous transparency demands of modern clinical environments.

Key facts. Cited by 2 papers in the map (data through 7 Oct 2026). Builds on 23 of its 37 references that are in the map. First posted on arXiv 7 Apr 2026.

Builds on

23 of 37 references.

References · 23

  1. 2023DINOv2: Learning Robust Visual Features without Supervisioncited by 7,764
  2. 2016Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localizationcited by 6,690
  3. 2021MedMNIST v2 -- A large-scale lightweight benchmark for 2D and 3D biomedical image classificationcited by 682
  4. 2024The Platonic Representation Hypothesiscited by 362
  5. 2014Understanding image representations by measuring their equivariance and equivalencecited by 240
  6. 2020MedMNIST Classification Decathlon: A Lightweight AutoML Benchmark for Medical Image Analysiscited by 206
  7. 2018Deep k-Nearest Neighbors: Towards Confident, Interpretable and Robust Deep Learningcited by 203
  8. 2021Revisiting Model Stitching to Compare Neural Representationscited by 203
  9. 2022Relative representations enable zero-shot latent space communicationcited by 175
  10. 2025Disentangling the Factors of Convergence between Brains and Computer Vision Modelscited by 12
  11. 2025Interactive Medical Image Analysis with Concept-based Similarity Reasoningcited by 11
  12. 2025Representation Potentials of Foundation Models for Multimodal Alignment: A Surveycited by 10
11 more
  1. 2024Rethinking model prototyping through the MedMNIST+ dataset collectioncited by 9
  2. 2025Proof of a perfect platonic representation hypothesiscited by 6
  3. 2025A Tale of Two Classes: Adapting Supervised Contrastive Learning to Binary Imbalanced Datasetscited by 5
  4. 2025Evaluating the Explainability of Vision Transformers in Medical Imagingcited by 4
  5. 2025Brain-Language Model Alignment: Insights into the Platonic Hypothesis and Intermediate-Layer Advantagecited by 4
  6. 2025Explaining the Unexplainable: A Systematic Review of Explainable AI in Financecited by 3
  7. 2023Medi-CAT: Contrastive Adversarial Training for Medical Image Classificationcited by 2
  8. 2025Explainable AI in Healthcare: to Explain, to Predict, or to Describe?cited by 2
  9. 2025In-hoc Concept Representations to Regularise Deep Learning in Medical Imagingcited by 2
  10. 2022Learning Discriminative Representation via Metric Learning for Imbalanced Medical Image Classificationcited by 1
  11. 2025Optimal Transport Adapter Tuning for Bridging Modality Gaps in Few-Shot Remote Sensing Scene Classificationcited by 1

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