Zero-Knowledge Federated Learning with Lattice-Based Hybrid Encryption for Quantum-Resilient Medical AI

Federated Learning (FL) enables collaborative training of medical AI models across hospitals without centralizing patient data. However, the exchange of model updates exposes critical vulnerabilities: gradient inversion attacks can reconstruct patient information, Byzantine clients can poison the global model, and the Harvest Now, Decrypt Later (HNDL) threat renders today's encrypted traffic vulnerable to future quantum adversaries.We introduce ZKFL-PQ (Zero-Knowledge Federated Learning, Post-Quantum), a three-tiered cryptographic protocol that hybridizes (i) ML-KEM (FIPS~203) for quantum-resistant key encapsulation, (ii) lattice-based Zero-Knowledge Proofs for verifiable norm-constrained gradient integrity, and (iii) BFV homomorphic encryption for privacy-preserving aggregation. We formalize the security model and prove correctness and zero-knowledge properties under the Module-LWE, Ring-LWE, and SIS assumptions in the classical random oracle model. We evaluate ZKFL-PQ on synthetic medical imaging data across 5 federated clients over 10 training rounds. Our protocol achieves 100% rejection of norm-violating updates while maintaining model accuracy at 100%, compared to a catastrophic drop to 23% under standard FL. The computational overhead (factor ~20×) is analyzed and shown to be compatible with clinical research workflows operating on daily or weekly training cycles. We emphasize that the current defense guarantees rejection of large-norm malicious updates; robustness against subtle low-norm or directional poisoning remains future work.