Multi-Objective Alignment of Language Models for Personalized Psychotherapy
On the map: LLM alignment / RLHF / preference optimisation → Medical LLM alignment
Abstract (arXiv)
Mental health disorders affect over 1 billion people worldwide, yet access to care remains limited by workforce shortages and cost constraints. While AI systems show therapeutic promise, current alignment approaches optimize objectives independently, failing to balance patient preferences with clinical safety. We survey 335 individuals with lived mental health experience to collect preference rankings across therapeutic dimensions, then develop a multi-objective alignment framework using direct preference optimization. We train reward models for six criteria -- empathy, safety, active listening, self-motivated change, trust/rapport, and patient autonomy -- and systematically compare multi-objective approaches against single-objective optimization, supervised fine-tuning, and parameter merging. Multi-objective DPO (MODPO) achieves superior balance (77.6% empathy, 62.6% safety) compared to single-objective optimization (93.6% empathy, 47.8% safety), and therapeutic criteria outperform general communication principles by 17.2%. Blinded clinician evaluation confirms MODPO is consistently preferred, with LLM-evaluator agreement comparable to inter-clinician reliability.
Key facts. No citing papers in the map yet (data through 7 Oct 2026). Placed in Medical LLM alignment, one of 10 directions in LLM alignment / RLHF / preference optimisation. Builds on 8 of its 31 references that are in the map. First posted on arXiv 17 Feb 2026.
Builds on
8 of 31 references.
References · 8
- 2023Judging LLM-as-a-Judge with MT-Bench and Chatbot Arenacited by 8,393
- 2022Training a Helpful and Harmless Assistant with Reinforcement Learning from Human Feedbackcited by 3,634
- 2023Personalized Soups: Personalized Large Language Model Alignment via Post-hoc Parameter Mergingcited by 271
- 2020A Computational Approach to Understanding Empathy Expressed in Text-Based Mental Health Supportcited by 182
- 2023Beyond One-Preference-Fits-All Alignment: Multi-Objective Direct Preference Optimizationcited by 121
- 2024Risks from Language Models for Automated Mental Healthcare: Ethics and Structure for Implementationcited by 27
- 2025ModelCitizens: Representing Community Voices in Online Safetycited by 1
- 2025Generative AI Purpose-built for Social and Mental Health: A Real-World Pilotcited by 1
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- 2025Empathy by Design: Aligning Large Language Models for Healthcare Dialogue
- 2026TherapyGym: Evaluating and Aligning Clinical Fidelity and Safety in Therapy Chatbots
- 2026Measuring What Matters!! Assessing Therapeutic Principles in Mental-Health Conversation
- 2026Alignment Plausibility: A New Standard for Assuring AI in Healthcare
- 2025Preference Learning Unlocks LLMs' Psycho-Counseling Skills
- 2026PAIR-SAFE: A Paired-Agent Approach for Runtime Auditing and Refining AI-Mediated Mental Health Support
- 2026Training Therapeutic Judges and Multi-Agent Systems for Human-Aligned Mental Health Support
- 2026AI Safety Training Can be Clinically Harmful