mlsanityData to 7 Oct 2026

A Generative AI Approach for Reducing Skin Tone Bias in Skin Cancer Classification

arXiv 2602.14356 ↗First posted 16 Feb 2026cs.CVcited by 0

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Abstract (arXiv)

Skin cancer is one of the most common cancers worldwide and early detection is critical for effective treatment. However, current AI diagnostic tools are often trained on datasets dominated by lighter skin tones, leading to reduced accuracy and fairness for people with darker skin. The International Skin Imaging Collaboration (ISIC) dataset, one of the most widely used benchmarks, contains over 70% light skin images while dark skins fewer than 8%. This imbalance poses a significant barrier to equitable healthcare delivery and highlights the urgent need for methods that address demographic diversity in medical imaging. This paper addresses this challenge of skin tone imbalance in automated skin cancer detection using dermoscopic images. To overcome this, we present a generative augmentation pipeline that fine-tunes a pre-trained Stable Diffusion model using Low-Rank Adaptation (LoRA) on the image dark-skin subset of the ISIC dataset and generates synthetic dermoscopic images conditioned on lesion type and skin tone. In this study, we investigated the utility of these images on two downstream tasks: lesion segmentation and binary classification. For segmentation, models trained on the augmented dataset and evaluated on held-out real images show consistent improvements in IoU, Dice coefficient, and boundary accuracy. These evalutions provides the verification of Generated dataset. For classification, an EfficientNet-B0 model trained on the augmented dataset achieved 92.14% accuracy. This paper demonstrates that synthetic data augmentation with Generative AI integration can substantially reduce bias with increase fairness in conventional dermatological diagnostics and open challenges for future directions.

Key facts. No citing papers in the map yet (data through 7 Oct 2026). Builds on 6 of its 24 references that are in the map. First posted on arXiv 16 Feb 2026.

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References · 6

  1. 2020Denoising Diffusion Probabilistic Modelscited by 20,851
  2. 2019EfficientNet: Rethinking Model Scaling for Convolutional Neural Networkscited by 6,415
  3. 2017Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)cited by 549
  4. 2018Generative Adversarial Network in Medical Imaging: A Reviewcited by 257
  5. 2018GAN-based Synthetic Medical Image Augmentation for increased CNN Performance in Liver Lesion Classificationcited by 242
  6. 2022Diffusion Models for Medical Anomaly Detectioncited by 231

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  1. 2025SkinGenBench: Generative Model and Preprocessing Effects for Synthetic Dermoscopic Augmentation in Melanoma Diagnosis
  2. 2024Cancer-Net SCa-Synth: An Open Access Synthetically Generated 2D Skin Lesion Dataset for Skin Cancer Classification
  3. 2025Prompting Medical Vision-Language Models to Mitigate Diagnosis Bias by Generating Realistic Dermoscopic Images
  4. 2025DermDiff: Generative Diffusion Model for Mitigating Racial Biases in Dermatology Diagnosis
  5. 2025SkinDualGen: Prompt-Driven Diffusion for Simultaneous Image-Mask Generation in Skin Lesions
  6. 2023Augmenting medical image classifiers with synthetic data from latent diffusion models
  7. 2025Adapting Large Language Models to Mitigate Skin Tone Biases in Clinical Dermatology Tasks: A Mixed-Methods Study
  8. 2026Bridging Research and Practice: A Systematic Evaluation of Generalist and Dermatology-Specific Models in Clinical Skin Lesion Classification