LiveMedBench: A Contamination-Free Medical Benchmark for LLMs with Automated Rubric Evaluation
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Abstract (arXiv)
The deployment of Large Language Models (LLMs) in high-stakes clinical settings demands rigorous and reliable evaluation. However, existing medical benchmarks remain static, suffering from two critical limitations: (1) data contamination, where test sets inadvertently leak into training corpora, leading to inflated performance estimates; and (2) temporal misalignment, failing to capture the rapid evolution of medical knowledge. Furthermore, current evaluation metrics for open-ended clinical reasoning often rely on either shallow lexical overlap (e.g., ROUGE) or subjective LLM-as-a-Judge scoring, both inadequate for verifying clinical correctness. To bridge these gaps, we introduce LiveMedBench, a continuously updated, contamination-free, and rubric-based benchmark that weekly harvests real-world clinical cases from online medical communities, ensuring strict temporal separation from model training data. We propose a Multi-Agent Clinical Curation Framework that filters raw data noise and validates clinical integrity against evidence-based medical principles. For evaluation, we develop an Automated Rubric-based Evaluation Framework that decomposes physician responses into granular, case-specific criteria, achieving substantially stronger alignment with expert physicians than LLM-as-a-Judge. To date, LiveMedBench comprises 2,756 real-world cases spanning 38 medical specialties and multiple languages, paired with 16,702 unique evaluation criteria. Extensive evaluation of 38 LLMs reveals that even the best-performing model achieves only 39.2%, and 84% of models exhibit performance degradation on post-cutoff cases, confirming pervasive data contamination risks. Error analysis further identifies contextual application-not factual knowledge-as the dominant bottleneck, with 35-48% of failures stemming from the inability to tailor medical knowledge to patient-specific constraints.
Key facts. Cited by 9 papers in the map (data through 7 Oct 2026). Builds on 19 of its 45 references that are in the map. First posted on arXiv 10 Feb 2026.
Builds on
19 of 45 references.
References · 19
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7 more
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Citing papers per year: 2026: 9.
9 papers.
- 2026CT Open: An Open-Access, Uncontaminated, Live Platform for the Open Challenge of Clinical Trial Outcome Predictioncited by 2
- 2026MentalHospital: A Virtual Environment for Evaluating Psychiatric Clinical Encounterscited by 1
- 2026RankLLM: Weighted Ranking of LLMs by Quantifying Question Difficultycited by 0
- 2026When Medical Safety Alignment Fails: A Benchmark for Evaluating LLMs on High-Risk Medical Queriescited by 0
- 2026MedRealMM: A Real-World Multimodal Benchmark for Chinese Online Medical Consultationcited by 0
- 2026APTER: Adaptive Post-Training with Expert-Grounded Rubricscited by 0
- 2026Dense Clinical Contrasts Enhance Medical Knowledge Updating in Large Language Modelscited by 0
- 2026A primer on evaluation methods for large language models in healthcarecited by 0
- 2026Are We Grading Properly? Understanding Failure Modes in Medical Benchmarkscited by 0
- 2026A primer on evaluation methods for large language models in healthcare13 Sep 2026
- 2026Are We Grading Properly? Understanding Failure Modes in Medical Benchmarks10 Sep 2026
- 2026Dense Clinical Contrasts Enhance Medical Knowledge Updating in Large Language Models31 Aug 2026
- 2026APTER: Adaptive Post-Training with Expert-Grounded Rubrics14 Aug 2026
- 2026MedRealMM: A Real-World Multimodal Benchmark for Chinese Online Medical Consultation10 Jul 2026
- 2026MentalHospital: A Virtual Environment for Evaluating Psychiatric Clinical Encounters9 Jul 2026
- 2026When Medical Safety Alignment Fails: A Benchmark for Evaluating LLMs on High-Risk Medical Queries26 May 2026
- 2026CT Open: An Open-Access, Uncontaminated, Live Platform for the Open Challenge of Clinical Trial Outcome Prediction17 Apr 2026
- 2026RankLLM: Weighted Ranking of LLMs by Quantifying Question Difficulty12 Feb 2026