Modality-Specific Enhancement and Complementary Fusion for Semi-Supervised Multi-Modal Brain Tumor Segmentation
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Abstract (arXiv)
Semi-supervised learning (SSL) has become a promising direction for medical image segmentation, enabling models to learn from limited labeled data alongside abundant unlabeled samples. However, existing SSL approaches for multi-modal medical imaging often struggle to exploit the complementary information between modalities due to semantic discrepancies and misalignment across MRI sequences. To address this, we propose a novel semi-supervised multi-modal framework that explicitly enhances modality-specific representations and facilitates adaptive cross-modal information fusion. Specifically, we introduce a Modality-specific Enhancing Module (MEM) to strengthen semantic cues unique to each modality via channel-wise attention, and a learnable Complementary Information Fusion (CIF) module to adaptively exchange complementary knowledge between modalities. The overall framework is optimized using a hybrid objective combining supervised segmentation loss and cross-modal consistency regularization on unlabeled data. Extensive experiments on the BraTS 2019 (HGG subset) demonstrate that our method consistently outperforms strong semi-supervised and multi-modal baselines under 1%, 5%, and 10% labeled data settings, achieving significant improvements in both Dice and Sensitivity scores. Ablation studies further confirm the complementary effects of our proposed MEM and CIF in bridging cross-modality discrepancies and improving segmentation robustness under scarce supervision.
Key facts. Cited by 1 paper in the map (data through 7 Oct 2026). Builds on 11 of its 18 references that are in the map. First posted on arXiv 10 Dec 2025.
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11 of 18 references.
References · 11
- 2019Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentationcited by 378
- 2019Transformation Consistent Self-ensembling Model for Semi-supervised Medical Image Segmentationcited by 138
- 2019Semi-Supervised Medical Image Segmentation via Learning Consistency under Transformationscited by 71
- 2021Modality-aware Mutual Learning for Multi-modal Medical Image Segmentationcited by 47
- 2018Few-shot 3D Multi-modal Medical Image Segmentation using Generative Adversarial Learningcited by 36
- 2023Towards Robust Natural-Looking Mammography Lesion Synthesis on Ipsilateral Dual-Views Breast Cancer Analysiscited by 10
- 2023Delving into Ipsilateral Mammogram Assessment under Multi-View Networkcited by 8
- 2025Semi-MoE: Mixture-of-Experts meets Semi-Supervised Histopathology Segmentationcited by 4
- 2024Robust Semi-supervised Multimodal Medical Image Segmentation via Cross Modality Collaborationcited by 3
- 2025Semi-Supervised Multi-Modal Medical Image Segmentation for Complex Situationscited by 1
- 2025DuetMatch: Harmonizing Semi-Supervised Brain MRI Segmentation via Decoupled Branch Optimizationcited by 1
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Citing papers per year: 2026: 1.
1 paper.