mlsanityData to 7 Oct 2026

A Novel Hierarchical Integration Method for Efficient Model Merging in Medical LLMs

arXiv 2511.13373 ↗First posted 17 Nov 2025cs.LG cs.AIcited by 0

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Abstract (arXiv)

Large Language Models (LLMs) face significant challenges in distributed healthcare, including consolidating specialized domain knowledge across institutions while maintaining privacy, reducing computational overhead, and preventing catastrophic forgetting during model updates.This paper presents a systematic evaluation of six parameter-space merging techniques applied to two architecturally compatible medical LLMs derived from the Mistral-7B base model. We introduce a novel hierarchical method that combines selective Optimal Transport (OT) alignment for attention layers with cosine similarity-weighted interpolation, designed to address permutation variance while minimizing computational overhead for edge deployment scenarios. Our study evaluates Task Arithmetic, Linear Averaging, DARE-TIES, DELLA, Breadcrumbs, and our Hierarchical approach across five medical benchmarks. Results demonstrate that architecturally compatible models benefit significantly from simple averaging methods, with Task Arithmetic achieving 45.80% accuracy on MedQA, outperforming complex pruning-based approaches. These findings offer critical insights for the deployment of distributed medical AI in resource-constrained IoT environments, where computational efficiency and model compatibility are paramount. Our work establishes that for architecturally compatible models, simple averaging provides a robust and computationally efficient baseline for knowledge consolidation, offering a pragmatic path forward for scalable medical AI systems.

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References · 19

  1. 2021LoRA: Low-Rank Adaptation of Large Language Modelscited by 14,084
  2. 2020Measuring Massive Multitask Language Understandingcited by 7,768
  3. 2019HellaSwag: Can a Machine Really Finish Your Sentence?cited by 4,018
  4. 2023QLoRA: Efficient Finetuning of Quantized LLMscited by 3,355
  5. 2023Mistral 7Bcited by 3,065
  6. 2022Large Language Models Encode Clinical Knowledgecited by 1,807
  7. 2022Model soups: averaging weights of multiple fine-tuned models improves accuracy without increasing inference timecited by 1,366
  8. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
  9. 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,271
  10. 2022Editing Models with Task Arithmeticcited by 1,076
  11. 2023TIES-Merging: Resolving Interference When Merging Modelscited by 795
  12. 2023Language Models are Super Mario: Absorbing Abilities from Homologous Models as a Free Lunchcited by 679
7 more
  1. 2021Merging Models with Fisher-Weighted Averagingcited by 613
  2. 2022MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answeringcited by 525
  3. 2022Git Re-Basin: Merging Models modulo Permutation Symmetriescited by 460
  4. 2024BioMistral: A Collection of Open-Source Pretrained Large Language Models for Medical Domainscited by 299
  5. 2019Model Fusion via Optimal Transportcited by 217
  6. 2023A Survey of Large Language Models for Healthcare: from Data, Technology, and Applications to Accountability and Ethicscited by 162
  7. 2024Parameter-Efficient Fine-Tuning of Large Language Models using Semantic Knowledge Tuningcited by 10

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