VoxTell: Free-Text Promptable Universal 3D Medical Image Segmentation
On the map: Multimodal LLMs / vision-language models → Medical vision-language models
Abstract (arXiv)
We introduce VoxTell, a vision-language model for text-prompted volumetric medical image segmentation. It maps free-form descriptions, from single words to full clinical sentences, to 3D masks. Trained on 62K+ CT, MRI, and PET volumes spanning over 1K anatomical and pathological classes, VoxTell uses multi-stage vision-language fusion across decoder layers to align textual and visual features at multiple scales. It achieves state-of-the-art zero-shot performance across modalities on unseen datasets, excelling on familiar concepts while generalizing to related unseen classes. Extensive experiments further demonstrate strong cross-modality transfer, robustness to linguistic variations and clinical language, as well as accurate instance-specific segmentation from real-world text. Code is available at: https://www.github.com/MIC-DKFZ/VoxTell
Key facts. Cited by 19 papers in the map (data through 7 Oct 2026). Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models. First posted on arXiv 14 Nov 2025.
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Citing papers per year: 2025: 1; 2026: 18.
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- 2025Comparing SAM 2 and SAM 3 for Zero-Shot Segmentation of 3D Medical Datacited by 2
- 2026CT-IDP: Segmentation-Derived Quantitative Phenotypes for Interpretable Abdominal CT Disease Classificationcited by 1
- 2026TriALS: Triphasic-Aided Liver Lesion Segmentation Benchmark in Non-Contrast CTcited by 1
- 2026Open-Ended CT Volume Segmentation with Weak Supervision from Languagecited by 1
- 2026TubeMLLM: A Foundation Model for Topology Knowledge Exploration in Vessel-like Anatomycited by 0
- 2026Hierarchical Text-Guided Brain Tumor Segmentation via Sub-Region-Aware Promptscited by 0
- 2026DGRNet: Disagreement-Guided Refinement for Uncertainty-Aware Brain Tumor Segmentationcited by 0
- 2026Exploiting Longitudinal Context in Clinician-Verified Interactive Lesion Trackingcited by 0
- 2026Decouple and Reason: Anatomically Guided Two-Stage Voxel-Level Grounding of Free-Text Findings in 3D Chest CTcited by 0
- 2026UniMedSeg: Unified In-Context Learning for Multi-Paradigm 2D/3D Medical Image Segmentationcited by 0
- 2026MedSAM2-Anatomy: Training-Free Inference-Time Optimization for Musculoskeletal Segmentationcited by 0
- 2026Text-Guided Refinement of Multi-sequence Glioma Subregion Segmentation with a Vision-Language Foundation Modelcited by 0
7 more
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- 2026MedPlex: Deep Vision-Language Co-Adaptation for Clinically Grounded Medical Segmentationcited by 0
- 2026Instance-Guided Report Anchoring for Text-Free 3D Abnormality Segmentation in Chest CTcited by 0
- 2026MedVA: An End-to-End Neuro-Symbolic Agentic System for Medical Volume Visualizationcited by 0
- 2026SAMI3D-DW: Interactive Segmentation of Any 3D Medical Imagescited by 0
- 2026Merlin Plus: A Large-Scale, Multi-Cancer, Image-Mask-Report Datasetcited by 0
- 2026Merlin Plus: A Large-Scale, Multi-Cancer, Image-Mask-Report Dataset29 Sep 2026
- 2026SAMI3D-DW: Interactive Segmentation of Any 3D Medical Images22 Sep 2026
- 2026MedVA: An End-to-End Neuro-Symbolic Agentic System for Medical Volume Visualization14 Sep 2026
- 2026Instance-Guided Report Anchoring for Text-Free 3D Abnormality Segmentation in Chest CT31 Aug 2026
- 2026MedPlex: Deep Vision-Language Co-Adaptation for Clinically Grounded Medical Segmentation13 Aug 2026
- 2026NeuroRefiner: Morphology-Aware Multi-Agent Refinement for 3D Fluorescence Microscopy Neuron Segmentation10 Aug 2026
- 2026EliSeg: Verified Target Construction for Report-Grounded Abnormality Segmentation7 Aug 2026
- 2026Text-Guided Refinement of Multi-sequence Glioma Subregion Segmentation with a Vision-Language Foundation Model5 Aug 2026
- 2026MedSAM2-Anatomy: Training-Free Inference-Time Optimization for Musculoskeletal Segmentation31 Jul 2026
- 2026Open-Ended CT Volume Segmentation with Weak Supervision from Language28 Jul 2026
- 2026UniMedSeg: Unified In-Context Learning for Multi-Paradigm 2D/3D Medical Image Segmentation14 Jul 2026
- 2026Decouple and Reason: Anatomically Guided Two-Stage Voxel-Level Grounding of Free-Text Findings in 3D Chest CT14 Jul 2026
7 more
- 2026Exploiting Longitudinal Context in Clinician-Verified Interactive Lesion Tracking22 May 2026
- 2026TriALS: Triphasic-Aided Liver Lesion Segmentation Benchmark in Non-Contrast CT15 May 2026
- 2026CT-IDP: Segmentation-Derived Quantitative Phenotypes for Interpretable Abdominal CT Disease Classification9 May 2026
- 2026DGRNet: Disagreement-Guided Refinement for Uncertainty-Aware Brain Tumor Segmentation22 Mar 2026
- 2026Hierarchical Text-Guided Brain Tumor Segmentation via Sub-Region-Aware Prompts22 Mar 2026
- 2026TubeMLLM: A Foundation Model for Topology Knowledge Exploration in Vessel-like Anatomy10 Mar 2026
- 2025Comparing SAM 2 and SAM 3 for Zero-Shot Segmentation of 3D Medical Data26 Nov 2025
- 2025Comparing SAM 2 and SAM 3 for Zero-Shot Segmentation of 3D Medical Datacited by 2
- 2026CT-IDP: Segmentation-Derived Quantitative Phenotypes for Interpretable Abdominal CT Disease Classificationcited by 1
- 2026TriALS: Triphasic-Aided Liver Lesion Segmentation Benchmark in Non-Contrast CTcited by 1
- 2026Open-Ended CT Volume Segmentation with Weak Supervision from Languagecited by 1
- 2026TubeMLLM: A Foundation Model for Topology Knowledge Exploration in Vessel-like Anatomycited by 0
- 2026Hierarchical Text-Guided Brain Tumor Segmentation via Sub-Region-Aware Promptscited by 0
- 2026DGRNet: Disagreement-Guided Refinement for Uncertainty-Aware Brain Tumor Segmentationcited by 0
- 2026Exploiting Longitudinal Context in Clinician-Verified Interactive Lesion Trackingcited by 0
- 2026Decouple and Reason: Anatomically Guided Two-Stage Voxel-Level Grounding of Free-Text Findings in 3D Chest CTcited by 0
- 2026UniMedSeg: Unified In-Context Learning for Multi-Paradigm 2D/3D Medical Image Segmentationcited by 0
- 2026MedSAM2-Anatomy: Training-Free Inference-Time Optimization for Musculoskeletal Segmentationcited by 0
- 2026EliSeg: Verified Target Construction for Report-Grounded Abnormality Segmentationcited by 0
12 most cited of 17 All 17 (JSON)
- 2026Merlin Plus: A Large-Scale, Multi-Cancer, Image-Mask-Report Dataset29 Sep 2026
- 2026SAMI3D-DW: Interactive Segmentation of Any 3D Medical Images22 Sep 2026
- 2026Instance-Guided Report Anchoring for Text-Free 3D Abnormality Segmentation in Chest CT31 Aug 2026
- 2026MedPlex: Deep Vision-Language Co-Adaptation for Clinically Grounded Medical Segmentation13 Aug 2026
- 2026NeuroRefiner: Morphology-Aware Multi-Agent Refinement for 3D Fluorescence Microscopy Neuron Segmentation10 Aug 2026
- 2026EliSeg: Verified Target Construction for Report-Grounded Abnormality Segmentation7 Aug 2026
- 2026MedSAM2-Anatomy: Training-Free Inference-Time Optimization for Musculoskeletal Segmentation31 Jul 2026
- 2026Open-Ended CT Volume Segmentation with Weak Supervision from Language28 Jul 2026
- 2026UniMedSeg: Unified In-Context Learning for Multi-Paradigm 2D/3D Medical Image Segmentation14 Jul 2026
- 2026Decouple and Reason: Anatomically Guided Two-Stage Voxel-Level Grounding of Free-Text Findings in 3D Chest CT14 Jul 2026
- 2026Exploiting Longitudinal Context in Clinician-Verified Interactive Lesion Tracking22 May 2026
- 2026TriALS: Triphasic-Aided Liver Lesion Segmentation Benchmark in Non-Contrast CT15 May 2026
12 newest of 17 All 17 (JSON)
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